| Title | Venue | Year | Impact | Source |
| 4351 | Evaluation of global niobium flow modeling and its market forecasting Metal, as the indispensable material, is functioning the society from technology to the environment. Niobium (Nb) is considered a unique earth metal as it is related to many emerging technologies. The increasing economic growth exerts an increasing pressure on supply, which leads to its significance in the economic sector. However, few papers have addressed Nb sustainability, which forms the scope of this paper in order to start the process of Nb market forecasting based on some previous data and some assumptions. Therefore, this paper will discuss different thoughts in material substitution and the substance flow of Nb throughout a static flow using Nb global data to have a better understanding of the process of Nb from production to end of life. This shall lead to the identification of the market needs to determine its growth which is around 2.5% to 3.0%. Moreover, due to China’s huge Nb consumption which comes from the continuous development that is happening over the years, it will also briefly mention the Nb situation as well as its growth which according to statistics will grow steadily till 2030 by a rate of 4.0% to 6.0%. The results show that there should be some enhancement to Nb recycling potentials out of steel scrap. In addition, there should be more involvement of Nb in different industries as this would lead to less-used materials which can be translated to less environmental impact. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available in the online version of this article at 10.1007/s11708-022-0823-y and is accessible for authorized users. | N/A | 2022 | | CORD-19 |
| 4352 | Saying yes to mess: disorganization as an antecedent to dynamic capabilities Modern businesses constantly operate in an environment filled with unpredictability. Such unpredictability and heightened dynamism require rapid responses, mainly prompted by the realization that such irregular phenomena cannot be dealt with using conventionally structured and organized approaches alone. In line with this ongoing conversation fuelled notably by the COVID-19 pandemic and its associated digital acceleration, in this paper, we lay out the case for how “actively embracing disorganization” as a new work form can be a mechanism that facilitates the creation and enactment of important dynamic capabilities thus enhancing a firm’s ability to cope with unpredictable environments. In doing so, we attempt to make a novel contribution outlining the relationship between disorganization and dynamic capabilities through propositions and an accompanying conceptual framework. In this article, we position disorganization as a form of organizational design capable of enabling the link between dynamic capabilities and performance. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11846-022-00540-w. | N/A | 2022 | | CORD-19 |
| 4353 | Inter-organizational social capital of firms in developing economies and industry 4.0 readiness: the role of innovative capability and absorptive capacity The globalization of markets provides opportunities for firms to collaborate on various activities. These collaborations are the resource of social capital for firms to achieve sustainable competitiveness. This study aims to investigate how social capital (i.e., structural, relational, and cognitive social capital) between firms in a developing economy and developed economy strengthens their innovation capability and enhance their industry 4.0 readiness. Using Smart PLS-SEM to analyse the data collected from 320 managers representing 81 manufacturing firms in Pakistan, we found that social capital is positively associated with industry 4.0 readiness, and innovative capability mediates this relationship. The study contributes to the existing knowledge of understanding industry 4.0 readiness and provides useful insights for firms in developing economy to improves their innovation capability during the industry 4.0 era. This study likewise reveals the significance of three dimensions of social capital, which can facilitate to bring in digital knowledge from developed economies to developed economies to get ready for the fourth industrial revolution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11846-022-00539-3. | N/A | 2022 | | CORD-19 |
| 4354 | The antinomies of sovereigntism, statism and liberalism in European democratic responses to the COVID-19 crisis: a comparison of Britain and France This paper argues that the current COVID-19 pandemic reveals and in a sense crystallizes a series of long-standing tensions about sovereignty that have become increasingly salient in the advanced capitalist democracies of the European Union. The spread of the pandemic led first to the activation of a conflict between a ‘sovereigntist reflex’ privileging the expression of national capacities and national self-reliance and a more ‘perforated’ understanding of sovereignty stressing the interdependence of peoples and states, both geographically and institutionally. As the response to COVID itself became more politicized we see the emergence of a second tension, between a libertarian ‘reflex’ supporting a residual state protecting liberties and facilitating individual choice and a sovereign-statist ‘instinct’, calling for an empowered guardian of the public good capable of ensuring collective security. A third tension relates to the seemingly growing opposition between a conception of sovereignty founded (and contingent) upon the will of the people and one in which the sovereign is, simultaneously, the discerner, defender and ultimate guarantor of the public good. After having mapped out these interwoven tensions and their main fault lines in general terms, the paper proceeds comparatively, tracking and tracing their (differential and specific) presence in governmental responses in two advanced capitalist democracies, France and Britain. | N/A | 2022 | | CORD-19 |
| 4355 | The Long Shadow of Public Interventions in the Financial Sector We take stock of the costs of government interventions in the financial sector over the period 2007–2017 and track the assets still under government control. We build a new bank-level dataset on interventions and holding divestitures covering 1114 financial institutions in 37 countries. At end-2017, few countries had fully divested their financial sector holdings. On average, public holdings were divested faster in more capitalized, profitable, and liquid banks. They remained higher in countries where private investment and credit growth grew slower, financial access, depth, efficiency, and competition were worse, and financial stability improved less. | N/A | 2022 | | CORD-19 |
| 4356 | It takes two to tango: technological and non-technological factors of Industry 4.0 implementation in manufacturing firms It is commonly held that new technologies improve the productivity of organizations. However, technology acceptance does not happen instantaneously—it depends on complementary, non-technological changes in organizational behaviour. The lack of the latter may present a barrier to technology implementation and could even result in adverse effects on productivity. This is often the case in emerging economies that are deeply embedded in mature technological frameworks and with limited readiness for the adoption of new technologies. Using data from organizations in the manufacturing sector of an emerging European economy, we empirically tested the effects of technological and non-technological factors of the organizational implementation of Industry 4.0 principles on productivity. The results of the investigation, based on structural equation modelling, reveal the positive effects of technology-related Industry 4.0 factors—such as the Internet of Things, cyber-physical systems, and cloud computing—on productivity. The findings also reveal that these effects are enhanced by the mediating effect of non-technological changes to business models, organizational structures and cultures, strategies, and shifts in focus regarding customers, products, and services. This study adds to the existing body of knowledge in this area by revealing the relevance of the individual channels through which transitions towards Industry 4.0 can be enhanced, using traditional manufacturing environments often neglected in studies within this research field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11846-022-00543-7. | N/A | 2022 | | CORD-19 |
| 4357 | Conflicts of sovereignty in contemporary Europe: a framework of analysis Contemporary conflicts of sovereignty in Europe have gone beyond the clash between national and supranational sovereignty. Sovereignty conflicts are increasingly occurring within member states. This paper develops a conceptual framework that distinguishes between foundational, institutional and territorial conflicts of sovereignty, elaborating on this taxonomy with reference to the historical evolution of the concept of sovereignty in Europe. It provides an account of why we have seen a proliferation in conflicts of sovereignty within European states. This is due in part to the notion of “shared” sovereignty. Central to European integration, this notion has introduced considerable institutional indeterminacy into the political systems of member states, leading to many of the institutional conflicts of sovereignty we see in Europe today. The struggle of national party systems to institutionalize societal conflict via partisan competition is another contributory factor. This has displaced conflict onto the terrain of how popular rule is institutionalized within the national state. In developing this framework, the paper provides a method for distinguishing between political conflicts tout court and those touching specifically upon sovereignty. Moreover, the framework helps us distinguish between those conflicts of sovereignty most destabilizing for a polity and those which are less so. | N/A | 2022 | | CORD-19 |
| 4358 | Sovereignty of what and for whom? The political mobilisation of sovereignty claims by the Italian Lega and Fratelli d'Italia This article looks at the relationship between conflicts of sovereignty and patterns of national party competition, by focusing on the electoral support for two Italian populist radical right parties (PRRPs), the Lega (the League, Lega) and Fratelli d’Italia (Brothers of Italy, FdI). Using public opinion data, the study finds that the conflicts of sovereignty represent a distinct and multidimensional set of attitudes related to voting preferences. Overall, these conflicts seem to provide some electoral advantage to the PRRPs over other competing parties in the electoral arena. However, they do not provide the same amount of gains to all PRRPs, since ideologies and party identities are important intervening factors in the relationship between conflicts of sovereignty, party mobilisation, and voting behaviour. | N/A | 2022 | | CORD-19 |
| 4359 | Higher Employee Engagement through Social Intelligence: A Perspective of Indian Scenario Recognizing that high levels of social intelligence are required for effective engagement, the authors set out to find the association between employee engagement and social intelligence. Specifically, the goal of this study was to find the explanatory value of social intelligence constructs for employee engagement in a sample of employees by conducting a statistical analysis. The final research included 150 male and 50 female professionals who were selected from FMCG sectors. A questionnaire was used to gather socio-demographic evidence; the Utrecht engagement scale and the Tromso social intelligence scale in the Indian cultural context were used to obtain professional and job information. The findings revealed that employees with high levels of social intelligence scores performed well on engagement measures, with social skills being the most significant predictor of engagement. The findings of this study have substantial practical significance for the development of training and intervention activities targeted at improving employees' performance on the job, among other things. | N/A | 2022 | | CORD-19 |
| 4360 | Predictors of severity and mortality in COVID-19 patients BACKGROUND: Due to limited capacity, health care systems worldwide have been put in challenging situations since the emergence of COVID-19. To prioritize patients who need hospital admission, a better understanding of the clinical predictors of disease severity is required. In the current study, we investigated the predictors of mortality and severity of illness in COVID-19 from a single center in Cairo, Egypt. METHODS: This retrospective cohort study included 175 patients hospitalized with COVID-19 pneumonia and had positive real-time polymerase chain reaction (RT-PCR) results for SARS-CoV-2 from 1 May 2020 to 1 December 2020. Severe COVID-19 was defined as requiring high-flow oxygen (flow rate of more than 8 L/min or use of high flow oxygen cannula), noninvasive ventilation, or invasive mechanical ventilation at any time point during the hospitalization. We used univariate and multivariate regression analyses to examine the differences in patient demographics and clinical and laboratory data collected during the first 24 h of hospitalization related to severe disease or death in all 175 patients. RESULTS: Sixty-seven (38.3%) of the study subjects had a severe or critical disease. Elevated d-dimer, leukocytosis, and elevated CRP were found to be independent predictors of severe disease. In-hospital mortality occurred in 34 (19.4%) of the cases. Elevated TLC, urea, the use of invasive mechanical ventilation, and the presence of respiratory bacterial co-infection were found to be independently associated with mortality. CONCLUSION: Clinical and laboratory data of COVID-19 patients at their hospital admission may aid clinicians in the early identification and triage of high-risk patients. | N/A | 2022 | | CORD-19 |
| 4361 | The Effect of Kerosene Pollution on the Cellulolytic Activity of Albic Retisols and Arenosols (Aridic): A Laboratory Experiment The results of a laboratory experiment modeling the effect of kerosene contamination on the cellulolytic activity of microbiocenosis of the Albic Retisol (Kaluga oblast, Russia) and Arenosol (Kyzylorda oblast, Republic of Kazakhstan) humus horizons are described. Cellulolytic activity is assessed according to the rate of weight loss in linen cloth fragments during the incubation for 0–3, 3–7, and 7–13 months. The intensity of cellulolytic activity in the unpolluted Albic Retisol is higher as compared with the Arenosol, which is determined by low acidity and an elevated content of organic matter and nutrients. The soil pollution with kerosene to 10 g/kg causes a reversible change in cellulolytic activity of both Albic Retisol and Arenosol (Aridic). A high load of kerosene (≥25 g/kg) inhibits cellulolytic activity in both soils over 13 months of observation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1134/S1064229322020119. Fig. S1. Cellulolytic activity of soils in a laboratory experiment: (a) initial state of linen tissue (test object) and (b) linen tissue after three months of incubation. Table S1. Properties of soil humus horizons. Table S2. Initial water content in the studied soil samples with due account for the added kerosene. Table S3. Cellulolytic activity in soils grouped according to kerosene load (rate of mass loss, mg/g soil per day. Table S4. Significance of differences between cellulolytic activities of contaminated soil samples relative control samples according to the Mann–Whitney U-test. Table S5. Kerosene content in the studied soil samples at the end of the experiment, % of the initial content. | N/A | 2022 | | CORD-19 |
| 4362 | Postdigital Research: Genealogies, Challenges and Future Perspectives | N/A | 2022 | | CORD-19 |
| 4363 | The community of inquiry framework for virtual team-to-team debriefings during interprofessional trauma simulations PURPOSE: Psychological safety is key to effective debriefing and learning. The COVID-19 pandemic necessitated rapid adaption of simulation events to virtual/hybrid platforms. We sought to determine the effect of utilizing the Community of Inquiry framework (CoI) for debriefing virtually connecting interprofessional learner teams on the psychological safety experienced during trauma simulations. METHODS: General surgery (GSR), emergency medicine (EMR) residents, trauma nurses/nurse practitioners and medical students participated in multiple simulation events designed to improve teamwork and leadership skills. Pre-course materials were provided before the event for learners to prepare. Briefings delineating expectations emphasized importance of and strategies employed to achieve psychological safety. Four unique clinical scenarios were run for each simulation event, with a debrief after each scenario. Virtual team-to-team debriefings were structured using the Community of Inquiry (CoI) conceptual framework. All learners completed pre-/post-assessments utilizing Inter-professional Collaborative Competencies Attainment Survey (ICCAS). RESULTS: Twenty-five learners participated (13 GSR, 5 EMR, 3 medical students, 2 trauma APRNs and 2 trauma RNs). Learner assessment found 88% (22) “agreed”/”strongly agreed” that virtual team-to-team debriefing had social, cognitive and educator presence per the CoI domains. However, one GSR and two nurse learners “strongly disagreed” with these statements. Most learners felt the debriefing was effective and safe. All participants “strongly agreed”/“agreed” the simulation achieved ICCAS competencies. CONCLUSIONS: Debriefings utilizing a virtual platform are challenging with multiple barriers to ensuring psychological safety and efficacy. By structuring debriefings using the CoI framework we demonstrate they can be effective for most learners. However, educators should recognize the implications of social identity theory, particularly the effects of hierarchy, on comfort level of learners. Developing strategies to optimize virtual simulation learning environments is essential as this valuable pedagogy persists during and beyond the COVID-19 pandemic. | N/A | 2022 | | CORD-19 |
| 4364 | EU Enlargement in Disregard of the Rule of Law: A Way Forward Following the Unsuccessful Dispute Settlement Between Croatia and Slovenia and the Name Change of Macedonia EU enlargement has always been a political process. That said, the rule of law is an important aspect and principle of the EU enlargement policy. Implementation of EU driven reforms in candidate countries largely depends on the rule of law-based enlargement as well as on a clear EU perspective. Overpoliticisation of the enlargement process renders the EU’s enlargement law futile and undermines both the transformative effect of the pre-accession process and EU’s own values. The implementation of the enlargement condition for settlement of bilateral disputes, which became pronounced in the EU enlargement towards the Western Balkan countries, is having the negative effect of contributing to deterioration rather than promotion of the rule of law in both EU candidate countries and the EU’s enlargement process. Lack of predictability and rule of law accordingly, makes the effective application of the principle of conditionality impossible. A genuine reconsideration of the condition for settlement of bilateral disputes within the EU enlargement framework, clear EU perspective and viable way forward are urgently needed for bringing rule of law and the EU’s credibility on track. | N/A | 2022 | | CORD-19 |
| 4365 | Innovation through internationalization: A systematic review and research agenda In this paper we perform a systematic literature review of the diverse and somewhat fragmented current state of research on firms’ internationalization and innovation. We analyze 207 key works from 1989 through 2020 and synthesize them into an internationalization process framework that conceptually maps key internationalization-related antecedents and moderators that influence innovation behaviors and outcomes. Through an internationalization process framework, we categorize existing relevant studies into three key stages: (a) the pre-internationalization stage, (b) the internationalization entry stage, and (c) the post-internationalization stage. Furthermore, we review how firms’ various strategic decisions and operations in different stages influence their innovations by elaborating the moderating role of external country/region institutions and firm internal characteristics. Building on this review, we provide suggestions for future research to advance the developments of this domain. | N/A | 2022 | | CORD-19 |
| 4366 | Outside the box: How globalization changed from moving stuff to spreading ideas: by Marc Levinson, 2020, Princeton University Press, New Jersey, 288 pp, $18.95, Paperback, ISBN: 9780691227092 | N/A | 2022 | | CORD-19 |
| 4367 | Assessment of Foreign Direct Investment-Led Growth Argument in South Africa Amidst Urbanization and Industrialization: Evidence from Innovation Accounting Tests The objective of this study is to investigate the FDI-led growth hypothesis for the case of South Africa for the period between 1970 and 2017. The preliminary analysis of unit root test using traditional methods shows a different order of integration, which necessitates the use of autoregressive distributive lag (ARDL) methodology. Additionally, the current study also leverages on the innovative accounting techniques which comprised of impulse response function and forecast error variance decomposition (FEVD), which are employed to explore the responsiveness of the variables on each other. Our study results show that FDI inflow exerts a very strong positive impact on economic growth, thus validating the FDI-induced growth nexus in the South African economy. Furthermore, causality results show a one-way link running only from FDI inflow to economic growth and a unidirectional connection from urbanization to FDI inflow. The implication is that only urbanization matters in attracting FDI inflow to South Africa. These outcomes suggest that there is a need for the government administrators to develop urban centers through improving infrastructure facilities and the provision of industrial zones as a way of expanding both the ready market and the absorptive capacity of the country. | N/A | 2022 | | CORD-19 |
| 4368 | In this month's Bulletin | Bull World Health Organ | 2022 | | CORD-19 |
| 4369 | Seminar-Highlights im Mai | Freie Zahnarzt | 2022 | | CORD-19 |
| 4370 | A novel approach for detection of COVID-19 and Pneumonia using only binary classification from chest CT-scans The novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread all over the world, causing a dramatic shift in circumstances that resulted in a massive pandemic, affecting the world's well-being and stability. It is an RNA virus that can infect both humans as well as animals. Diagnosis of the virus as soon as possible could contain and avoid a serious COVID-19 outbreak. Current pharmaceutical techniques and diagnostic methods tests such as Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Serology tests are time-consuming, expensive, and require a well-equipped laboratory for analysis, making them restrictive and inaccessible to everyone. Deep Learning has grown in popularity in recent years, and it now plays a crucial role in Image Classification, which also involves Medical Imaging. Using chest CT scans, this study explores the problem statement automation of differentiating COVID-19 contaminated individuals from healthy individuals. Convolutional Neural Networks (CNNs) can be trained to detect patterns in computed tomography scans (CT scans). Hence, different CNN models were used in the current study to identify variations in chest CT scans, with accuracies ranging from 91% to 98%. The Multi class Classification method is used to build these architectures. This study also proposes a new approach for classifying CT images that uses two binary classifications combined to work together, achieving 98.38% accuracy. All of these architectures' performances were compared using different classification metrics. | N/A | 2022 | | CORD-19 |
| 4371 | An overview of data reduction solutions at the edge of IoT systems: a systematic mapping of the literature Internet of Things (IoT) is a technology that connects devices of different types and characteristics through a network. The massive quantity of the heterogeneous generated data by the sensors imposes many challenges in making these data available to IoT applications. Data reduction and preprocessing are promising concepts that help to handle these data efficiently before storing them. Applying data reduction methods at the edge has emerged as an efficient solution. In such context, this systematic mapping is intended to investigate the data reduction solutions performed exclusively at the edge through a set of research questions. To reach this objective, we performed a Systematic Literature Mapping (SLM) in which 35 papers were strictly analyzed among a total of 853 articles. Finally, we present the results of these analyses answering questions that relate to the researcher’s used techniques, hardware technologies, used data type, and contributed objects to perform the data reduction techniques on the edge of the IoT systems. | N/A | 2022 | | CORD-19 |
| 4372 | Life Sciences Discovery and Technology Highlights | SLAS Technol | 2022 | | CORD-19 |
| 4373 | Life Sciences Discovery and Technology Highlights | SLAS Technol | 2022 | | CORD-19 |
| 4374 | What happens to your body during learning with computer-based environments? Exploring negative academic emotions using psychophysiological measurements This explorative study aims to examine if electrodermal activity (EDA) and heart rate (HR) are appropriate measures for identifying and monitoring academic emotions during learning in computer-based learning environments (CBLEs). Understanding learners' emotions while using CBLEs, allows improving the design of CBLEs. Therefore, we collected EDA, HR, and self-report data from 32 participants to measure academic emotions during learning with CBLEs in a laboratory setting. We induced negative academic emotions during learning using harmful connotated learning content about animal welfare. In a pre-post design, participants reported their emotional state before and after learning. We collated the self-reports with the EDA and HR curves to identify the emotional change in real-time. We prepared the data for repeated measurement analyses and group differences (high-, middle-, low learning performance; bored vs. not bored participants). Negative academic emotions were detected in increased EDA and HR. EDA turned out to be an indicator of learning performance. Boredom manifested in HR decrease. Findings show that EDA and HR are appropriate tools to measure academic emotions. We want to show the importance of real-time measures for learning and the efficiency of EDA and HR measures. It is worth considering EDA as a predictor for learning success and implementing EDA and HR measurements in CBLEs. However, more research is needed to clarify the role of HR in the context of learning performance. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40692-022-00228-w. | N/A | 2022 | | CORD-19 |
| 4375 | Whiteness in the COVID-19 Pandemic: Who is Talking About Racism With Their Kids? The present study investigated factors associated with parent awareness and socialization surrounding COVID-19-related racial disparities among White parents of children ages 1.5–8 living in Canada and the United States (N = 423, 88% mothers). Participants responded to an online survey about parenting during the pandemic between mid to late-April 2020. Participants reported on their level of awareness of COVID-19-related racial disparities as well as how often they discussed these with their children. Although 52% reported some level of awareness, only 34% reported any amount of discussion with their child about it. Regression models were used to further examine stress-related, socioeconomic, parenting, and news-watching associations with awareness and socialization. This study provides unique insight into which White parents are aware of racial inequities exposed by the pandemic and which are choosing to speak to their children about them. Current summary recommendations for White racial socialization and related research are also presented. | J Fam Issues | 2022 | | CORD-19 |
| 4376 | Domestic Military Deployments in Response to COVID-19 Militaries are commonly deployed in response to domestic disasters. However, our understanding of this phenomenon remains incomplete, partly because the particulars of disasters make it hard to generalize about deployments used in response. This article leverages the COVID-19 pandemic’s global reach to systematically evaluate common hypotheses about when and how militaries are used to respond to domestic disasters. It presents original global data about domestic military deployments in pandemic response and uses it to assess common theoretical expectations about what shapes whether and how militaries are used in such contexts. The results suggest that decisions about whether to deploy militaries stem from the securitization of domestic disaster relief rather than being responses to specific disaster-related features, state capacity shortcomings, or other social or political factors, even as some of these elements shaped how militaries were used. The article concludes by outlining some hypotheses for future research about the impact of this securitization on civil–military relations. | Armed Forces Soc | 2022 | | CORD-19 |
| 4377 | Separation and Discrimination: The Lived Experience of COVID-19 Survivors in Philippine Isolation Centers Social isolation in times of pandemic can affect the well-being of individuals infected with a contagious disease. This study explores the lived experience of the 12 COVID-19 survivors placed in community-based isolation centers in Cebu City, Philippines and whose cases were mild and asymptomatic. In describing their lived experience, we employed Max van Manen's phenomenology of practice. Results show that the COVID-19 survivors have suffered more from the consequences of separation and discrimination than the disease's physiological effects. Educating the whole community about social responsibility and ethical behavior in dealing with COVID-19 survivors is essential to minimize social stigma and discrimination. | Illn Crises Loss | 2022 | | CORD-19 |
| 4378 | HAS THE COVID-19 PANDEMIC IMPACTED THE MANAGEMENT OF CHRONIC MUSCULOSKELETAL PAIN? | Osteoarthritis Cartilage | 2022 | | CORD-19 |
| 4379 | MACHINE LEARNING AND RADIOMICS IDENTIFY NOVEL BIOMARKERS OF BONE LOSS Purpose: Altered bone turnover is a factor in many diseases including osteoarthritis (OA), osteoporosis, inflammation, and viral infection. The absence of obvious symptoms and insufficiently sensitive biomarkers in the early stages of bone loss limits early diagnosis and treatment. Therefore, it is urgent to identify novel, more sensitive, and easy-to-detect biomarkers which can be used in the diagnosis and prognosis of bone health. Our previous data using standard micro-computed tomography (μCT) measurements showed that SARS-CoV-2 infection in mice significantly decreased trabecular bone volume at the lumbar spine, suggesting that decreased bone mass, increased fracture risk, and OA may be underappreciated long-haul comorbidities for COVID patients. In this study, we applied integrated state-of-the-art radiomics and machine learning models to identify more sensitive image-based biomarkers of SARS-CoV-2-induced bone loss from μCT images. These radiomic biomarkers can potentially provide a non-invasive way of quantifying and monitoring systemic bone loss and evaluating treatment efficacy in both research and clinical practices. Methods: All animal use was performed with approval of the Institutional Animal Care and Use Committee. To quantify SARS-CoV-2-induced bone loss, 6-week-old transgenic mice (16 male, 16 female) expressing humanized ACE2 receptors were inoculated with a 2020 strain of SARS-CoV-2 or phosphate-buffered saline (Control) [Fig. A]. Viral infection was confirmed by detection of infectious SARS-CoV-2 in throat swabs and histological identification of SARS-CoV-2 labeled cells. At 6-14 days post-infection, lumbar vertebral bodies (L5) were scanned with μCT (μCT 35, SCANCO Medical AG;6 μm nominal voxel size). The open-source research platform 3D Slicer v2020 with a built-in Python console v3.8 was used for medical image computing and fully automated segmentation of cortical and trabecular bone. Standard μCT assessment of bone microstructure was performed. Radiomic feature extraction and data processing were performed using python based PyRadiomics v3.0.1. A total of 120 radiographic features were extracted from the segmented images [Fig. B]. Principle component analysis (PCA) for feature selection, a support vector machine learning (SVML) predictive model for classification, holdback method for model validation, and all statistical analyses (significance at p<0.05) were performed using JMP Pro v15 (SAS). Results: Using standard μCT methods, SARS-CoV-2 infection significantly reduced the bone volume fraction (BV/TV) by 10 and 10.5% (p= 0.04) and trabecular thickness (Tb.Th) by 8 and 9% (p= 0.02) in male and female mice, respectively, compared to PBS control mice [Fig. C]. Radiomics detected a 20-fold greater magnitude in change over standard methods. SARS-CoV-2 infection significantly changed radiographic parameters with the largest change being a 300% increase in the second-order parameter: cluster shade [Fig. D]. The 45 radiomic features comprising the first 3 principal components were selected for inclusion in the SVML model. The SVML Model (radial basis function kernel;cost = 4.8;gamma = 0.46) produced an area under the receiver operating characteristic curve (AUC) of 1.0 which reflects a perfectly accurate test [Fig. E]. Conclusions: SARS-CoV-2 infection of humanized ACE2 expressing mice caused significant bone changes, suggesting that decreased bone mass, increased fracture risk, OA, and other musculoskeletal complications could be long-term comorbidities for people infected with COVID-19. We developed an open-source, fully automated segmentation and radiomics system to assess systemic bone loss using μCT images. When coupled with machine learning, this system was able to identify novel radiographic biomarkers of bone loss that better discriminate differences in bone microstructure between SARS-CoV-2 infected and control mice than standard bone morphometric indices. The high accuracy of the SVML model in classifying SARS-CoV-2 infected mice opens the possibility of translating these biom rkers to the clinical setting for early detection of skeletal changes associated with long-haul COVID. The methods presented here were demonstrated using SARS-CoV-2 as a model system and can also be adapted to other diseases associated with altered bone turnover. Development of machine-learning methods for radiomic applications is a crucial step toward clinically relevant radiomic biomarkers of bone health and provides a non-invasive way of quantifying and monitoring systemic bone loss and evaluating treatment efficacy. [Formula presented] | Osteoarthritis Cartilage | 2022 | | CORD-19 |
| 4380 | COVID-19 & OA: From a Pharmacological Perspective | Osteoarthritis Cartilage | 2022 | | CORD-19 |
| 4381 | Does airway pressure release ventilation offer new hope for treating acute respiratory distress syndrome? Mechanical ventilation (MV) is an essential life support method for patients with acute respiratory distress syndrome (ARDS), which is one of the most common critical illnesses with high mortality in the intensive care unit (ICU). A lung-protective ventilation strategy based on low tidal volume (LTV) has been recommended since a few years; however, as this did not result in a significant decrease of ARDS-related mortality, a more optimal ventilation mode was required. Airway pressure release ventilation (APRV) is an old method defined as a continuous positive airway pressure (CPAP) with a brief intermittent release phase based on the open lung concept; it also perfectly fits the ARDS treatment principle. Despite this, APRV has not been widely used in the past, rather only as a rescue measure for ARDS patients who are difficult to oxygenate. Over recent years, with an increased understanding of the pathophysiology of ARDS, APRV has been reproposed to improve patient prognosis. Nevertheless, this mode is still not routinely used in ARDS patients given its vague definition and complexity. Consequently, in this paper, we summarize the studies that used APRV in ARDS, including adults, children, and animals, to illustrate the settings of parameters, effectiveness in the population, safety (especially in children), incidence, and mechanism of ventilator-induced lung injury (VILI) and effects on extrapulmonary organs. Finally, we found that APRV is likely associated with improvement in ARDS outcomes, and does not increase injury to the lungs and other organs, thereby indicating that personalized APRV settings may be the new hope for ARDS treatment. | N/A | 2022 | | CORD-19 |
| 4382 | Education in a datafied world: Balancing children's rights and school's responsibilities in the age of Covid 19 The Covid-19 pandemic created a situation where online learning extended at speed. During the national lockdowns, when it was not possible for most children to physically attend school, the efficacy and efficiency of digital platforms made it possible for schools to fulfill their duties to provide an education. However, the urgency of the situation carried the risk that this was put in place without adequate consideration of the data protection risks from various online learning tools. Although the General Data Protection Regulation (GDPR) provides a framework of regulations and rights to protect users, the legal process is unwieldy to apply due to tensions in balancing the rights of the child learner with the public need to ensure that all children are provided with an education. This paper recommends that changes in digital schooling practices are needed so that children have realistically possible ways of enforcing their data protection rights as well as a clarified and uniformed approach to support schools. | N/A | 2022 | | CORD-19 |
| 4383 | SKALP-AKUPUNKTUR UND HERZRATENVARIABILITÄT BEI PATIENTEN NACH SCHLAGANFALL MIT SCHLAFSTÖRUNGEN: TELEAKUPUNKTUR MIT HARBIN IN COVID-19-PANDEMIE-ZEITEN The difficult times caused by the COVID-19 pandemic and the associated problems, also in the area of research management of intercontinental acupuncture research projects, require targeted, adequate solutions. For example, the author’s research project approved by Eurasia Pacific Uninet, which should have been carried out through a mutual exchange of scientists, could only be carried out “online” due to corona using the now established method of tele acupuncture. This report is focused on the long-term cooperation between the TCM (Traditional Chinese Medicine) Research Center of the Medical University of Graz in Austria and the Heilongjiang University in Harbin in China. In addition to the methodology of scalp acupuncture, the interventions and the assessment using heart rate variability (HRV), the article summarizes the results of patients with sleep disorders. According to the results of this pilot project, scalp acupuncture can be used as an effective method for stroke patients with insomnia and spleen qi deficiency. A discussion of scalp acupuncture in connection with HRV as well as historical considerations on the topic complete the project report. | N/A | 2022 | | CORD-19 |
| 4384 | ... UND JÄHRLICH GRÜSST DAS MURMELTIER! | N/A | 2022 | | CORD-19 |
| 4385 | DGKiZ-News: Neues aus der Deutschen Gesellschaft für Kinderzahnheilkunde | N/A | 2020 | | CORD-19 |
| 4386 | Preoxygenation in the Covid-19 era: Worth a second look? | N/A | 2022 | | CORD-19 |
| 4387 | Strategic leadership in the EU multilevel parliamentary field: the EPP Group's Erasmus Programme This article, for the first time, analyses vertical networking among parliamentary groups and elected politicians from the same Europarty in the EU. It explores how, concerned about its growing ideological diversity, political fragmentation and recent sovereigniste tendencies, the European People’s Party Group in the European Parliament has sought to exercise strategic leadership within the EU multilevel parliamentary field by systematizing its cooperation with younger national MPs. Drawing on a mixed-methods approach including document analysis, elite interviews, and a participant survey, the article traces the origins, motivations, and implementation since 2016 of the EPP Group’s unique Erasmus Programme for visits by such national MPs to Brussels. It shows that participation enhanced the MPs’ knowledge about the EPP Group, the EP, and the EU. It also created new contacts between them and the EPP Group and other EP actors, and it contributed somewhat to legitimising the EPP Group’s role for national politics. It remains to be seen, however, whether increased vertical parliamentary networking will be both sustainable, not ephemeral, and transnational, not national—long-term effects that could only be traced with the help of a longitudinal research design. | N/A | 2022 | | CORD-19 |
| 4388 | E-content development of English language courses during COVID-19: a comprehensive analysis of students' satisfaction There was a sudden switch to online learning approaches because of the COVID-19 pandemic. Universities were under pressure to provide a variety of e-learning designs during a short time, impacting the quality of the learning. This study tended to evaluate the quality of e-content development related to English language courses by Shiraz University of Medical Sciences (SUMS) faculties. The survey was conducted on 610 undergraduate students of SUMS who had an English course in the first semester which was during the same time that the pandemic started. A self-devised questionnaire including 30 items in five main domains: physical design, affective design, cognitive design (e-content organization and multimedia principles), flexibility, and ease of use was used to achieve students’ satisfaction around the quality of the e-content developed by their teachers. Data were analyzed using SPSS 22 via one-sample t-test, Independent t-test, and ANOVA. Despite the limitations of e-content development by teachers, students had a satisfactory perception overall. Among the dimensions of e-content quality, physical design, cognitive design, ease of use, and flexibility had a score higher than the cut-off point but the score of the affective design was less. In addition, the differences were significant concerning age, gender, degree, type of digital device, and the faculties. It seems that in the situation of pandemics and lack of access to students, faculty members in terms of structural and cognitive dimensions have been able to develop satisfactory e-content in a short and intensive time, but it is necessary to be motivating, interactive, and up-to-date. | N/A | 2022 | | CORD-19 |
| 4389 | Can Regulatory Efforts Motivate Innovation? The Case of Ventilator Innovations During COVID In 2020, the United States Food and Drug Administration enacted the Emergency Use Authorization (EUA) to help respond to the COVID-19 pandemic. This regulatory pathway allowed for alternative uses of the existing medical devices and temporary authorization of new medical device designs, including ventilators. Given that regulation is often seen as a barrier to innovation, looking at ventilator innovation under the EUA is a good case study to explore if reducing regulatory barriers leads to increased or different forms of innovation. In this article, publicly available data are used to track the nature of innovation across all forms of ventilators submitted under the EUA pathway. We found that the EUA encouraged innovation in the ventilator industry, as indicated by new entrants to the medical device industry, a shift in the types of ventilators submitted for approval, and a wide variety of innovations. It also promoted new management practices to facilitate innovation, such as frugal design, a broader range of collaboration, and the use of open-source designs; these practices can be more widely used by industry to reduce costs, increase innovation, and serve traditionally underserved markets. | N/A | 2021 | | CORD-19 |
| 4390 | Evolution des données de neuro-imagerie chez les patients COVID-19 sévères avec atteinte neurologique initiale Introduction Les complications cérébrales aiguës en lien avec la COVID-19 ont été largement documentées par IRM cérébrales. Le but de cette étude était de présenter l’évolution des données de neuro-imagerie (IRM et PET-TDM au 18F-FDG) chez les patients guéris de la COVID-19. Matériels et méthodes Durant la première vague de la pandémie de COVID-19 entre le 1er mars et le 31 mai 2021, 112 consécutifs patients COVID-19 ayant des manifestations neurologiques ont réalisées une IRM cérébrale aux Hôpitaux Universitaires de Strasbourg. Après guérison, durant le suivi, parmi ces 112 patients, 31 ont réalisé des examens d'imagerie complémentaires (au moins une IRM cérébrale). L'ensemble de ces 31 patients était initialement hospitalisé en réanimation pour une maladie sévère. Résultats 23 hommes (74%) et 8 (26%) femmes ont été inclus avec une moyenne d’âge de 61 ans (18-79 ans). Les diagnostics retenus sur la première IRM cérébrale regroupaient: i) Prise de contraste leptoméningées; ii) Microsaignements diffus (« Critical illness-associated cerebral microbleeds »); iii) AVC ischémique; iv) Suspicion de vascularite cérébrale; v) Lésions démyélinisantes inflammatoires aiguës. Durant le suivi, l’évolution des prises de contraste leptoméningées était dissociée et les microsaignements étaient stables. Les anomalies artérielles pariétales ont régressé chez l'ensemble des sujets ayant une suspicion de vascularite cérébrale. 4 (13%) patients ont présenté de nouvelles complications durant le suivi: AVC ischémique, névrite, nette augmentation de la charge lésionnelle vasculaire chez un patient avec une suspicion initiale de vascularite cérébrale, apparition d'un rehaussement pariétal artériel évocateur d'une vascularite cérébrale. La majorité de nos patients ont démontré une normalisation, au moins partielle, de la perfusion cérébrale. Concernant la volumétrie cérébrale, nous avons observé une perte de volume de 3.2% pour la substance grise sur une période moyenne de 5 mois. Concernant les données de médecine nucléaire, les principaux résultats observés étaient des hypométabolismes temporo-insulaire et des hypermétabolismes des colliculi. Conclusion Lors du suivi, une minorité de nos patients inclus ont démontré de nouvelles complications en imagerie. Déclaration de liens d'intérêts Les auteurs n'ont pas transmis leur déclaration de liens d'intérêts. | J Neuroradiol | 2022 | | CORD-19 |
| 4391 | Aspects radiologiques du neuro-COVID: véritable lien de causalité ou simple coïncidence Introduction Le neuro-Covid désigne l'ensemble des atteintes du système nerveux associées à l'infection par Sars-CoV-2, et regroupe des entités variées. Elles touchent 8 à 13 % des patients hospitalisés pour infection Covid. Il s'agit soit d'une atteinte directe Objectif L'objectif de notre étude est d'analyser le profil clinico-radiologique des patients étiqueter neuroCovid et de détailler les différents critères permettant de rattacher l'atteinte neurologique à l'infection par le Sars-Cov2. Patients et méthodes Il s'agit d'une étude rétrospective sur dossiers médicaux de 52 patients, colligés au sein du service de neurologie du CHU Mohammed VI d'Oujda, durant une période allant de Mars 2020 à Novembre 2021. Tous les patients ont bénéficié d'un examen clinique rigoureux, d'une IRM médullaire et / ou encéphalique, d'un bilan biologique exhaustif et d'un suivi régulier. Résultats L’âge moyen de nos patients était de 42 ans, avec des extrêmes d’âge, allant de 16 à 71 ans. Le sex-ratio (H/F) était de 0,7. Le raisonnement étiologique s'est basé sur le contexte clinique, l'IRM du névraxe, le bilan biologique et l’évolution sous traitement. Plusieurs aspects radiologiques ont été retrouvés : les accidents ischémiques cérébraux (38%), les encéphalopathies nécrotico-hémorragiques (35%), les atteintes neuro-inflammatoires (21%), telles que des encéphalites ou des myélites, mais également les myéloradiculites (5%). Discussion l'IRM est l'examen de première intention dans l'exploration d'une atteinte neurologique centrale du Sars-Cov-2. Elle permet de mettre en évidence d'une part la lésion responsable du tableau clinique et d'autre part d’éliminer plusieurs hypothèses diagnostiques. La discussion diagnostique se base sur l'exclusion des étiologies pouvant être à l'origine de l'affection neurologique, en se basant sur les données récentes de la littérature, et sur l’évolution sous traitement. Conclusion Le diagnostic étiologique des neuro-Covid reste difficile. La démarche diagnostique doit être rigoureuse pour ne pas lier tout symptôme à l'infection Covid. Déclaration de liens d'intérêts Les auteurs n'ont pas transmis leur déclaration de liens d'intérêts. | J Neuroradiol | 2022 | | CORD-19 |
| 4392 | Virtual nutrition class curriculum development for patients with inborn errors of metabolism to curb COVID-19 isolation | Mol Genet Metab | 2022 | | CORD-19 |
| 4393 | Examining the self-described impact of COVID-19 on the lives and interactions of adults with PKU | Mol Genet Metab | 2022 | | CORD-19 |
| 4394 | Monitoring the change of Turkey's tourism city Antalya's Konyaaltı shoreline with multi-source satellite and meteorological data Uncontrolled tourism activities cause the destruction of nature and deterioration of the ecological balance. Since coastal areas are both economically and socially important, monitoring shoreline changes has become one of the important research areas. Monitoring short-term and long-term changes in coastal areas is important to prevent damages that may occur due to natural and human factors and protect the shorelines. In this study, which is an important tourist city of Antalya, Turkey, and the world, coastal changes using historical and recent satellite data have been analyzed. The focus of the study is to analyze long-term coastal change with Landsat data and the data obtained every 5 years between 1985 and 2020 and to analyze short-term change with annual Sentinel-2 data between 2015 and 2020. In the study, water areas on the coastline were determined by object-based classification and multiresolution segmentation method with the Modified Normalized Difference Water Index (MNDWI). The obtained shorelines were analyzed with the Digital Shoreline Analysis System (DSAS) tool and the changes in the coastal areas were determined statistically. Five-year and 35-year changes were compared with Linear Regression Rate (LRR) and End Point Rate (EPR) analyses. As a result of the study, when the Pearson’s r value between EPR and LRR was examined, r was found 0.916 and 0.944 for 5-year and 35-year data, respectively. Spatial resolution in satellite images is vital for shoreline detection. However, the most optimal way to detect long-term changes in the shoreline is to use Landsat data. Although the spatial resolution of Landsat data, it has been observed that the power to analyze annual variation differences is lower than Sentinel-2. | N/A | 2022 | | CORD-19 |
| 4395 | Humble Behaviorism Redux The need to bring behavior analysis to scale is no more obvious or urgent than now. Collaboration between behavior analysts and healthcare workers, educators, policymakers, mental health clinicians, social workers, and so many other professionals is critical to reaching under-resourced and traditionally marginalized populations. First, however, interprofessional collaboration must be adopted widely and reinforced within the behavior analytic community. Disciplinary centrism and hubris pose barriers to effective interprofessional collaboration, leading one to assume the position that practitioners of the same discipline are better trained and smarter than those of a different field. However, cultural humility (Wright, Behavior Analysis in Practice, 12(4), 805–809, 2019) is an alternative to disciplinary centrism that allows professionals to retain identities born of cultural histories and training (Pecukonis, Journal of Teaching in Social Work, 40(3), 211–220, 2020). Furthermore, cultural reciprocity is a process of self-observation and collaborative inquiry that involves questioning one’s own assumptions and forces individuals (and professions) to confront the contradictions between their values and their practices (Kalyanpur & Harry, 1999). In this paper, we revisit the call for Humble Behaviorism first made by Alan Neuringer in 1991 and the recommendations of fellow behavior analysts since. Specifically, we introduce a framework of cultural reciprocity to guide humble behaviorists as they acquire behaviors necessary to establish and maintain productive interprofessional relationships. We encourage them to act on their ethical and moral duties to address social problems of global concern and bring behavior analysis to scale. | N/A | 2022 | | CORD-19 |
| 4396 | Koordinierte Durchsetzung durch 22 Aufsichtsbehörden zur Nutzung von Cloud-Diensten durch den öffentlichen Sektor | N/A | 2022 | | CORD-19 |
| 4397 | Methylprednisolone: Fungaemia following an off-label use: case report | N/A | 2022 | | CORD-19 |
| 4398 | Other adverse reaction research | N/A | 2022 | | CORD-19 |
| 4399 | AZD-1222: Vaccine associated hypermetabolic abdominal and cervical lymph nodes mimicking Hodgkin lymphoma relapse: case report | N/A | 2022 | | CORD-19 |
| 4400 | Kinder- und Jugendsport „nach" Corona: Die Bedeutung von Bewegung, Spiel und Sport für ein gesundes Aufwachsen | N/A | 2022 | | CORD-19 |
