| Title | Venue | Year | Impact | Source |
| 3051 | P5-67: Predictors of mortality in severe COVID-19 pneumonia: An interim analysis from a single Tertiary Care Centre in Central Sri Lanka | Respirology | 2021 | | CORD-19 |
| 3052 | COVID-19 and older adults with Down syndrome: Presentation, complications and risk for mortality BACKGROUND: Health conditions (including high rates of Alzheimer's disease, AD), immune dysfunction, and premature aging associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID‐19. METHOD: The T21RS COVID‐19 Initiative launched an international survey for clinicians or caregivers on patients with COVID‐19 and DS. Data collected between April and October 2020 (N=1046) were analysed and compared with the UK ISARIC4C survey of hospitalized COVID‐19 patients with and without DS. RESULT: Mortality rates in individuals with DS diagnosed with COVID‐19 showed a rapid increase from age 40 and were considerably higher in patients with DS (T21RS DS versus non‐DS patients: risk ratio (RR)=3.5 (95%‐CI=2.6;4.4), ISARIC4C DS versus non‐DS patients: RR=2.9 (95%‐CI=2.1;3.8)) even after adjusting for known risk factors for COVID‐19 mortality. Similar to the general population, the most frequent signs and symptoms of COVID‐19 were fever, cough, and shortness of breath. Joint/muscle pain and vomiting or nausea were less frequent (p<0.01), whereas altered consciousness/confusion were more frequent (p<0.01). Risk factors for hospitalization and mortality included age, male gender, diabetes, obesity, and AD, with the addition of congenital heart defects as a risk factor for hospitalization. CONCLUSION: Individuals with DS and COVID‐19 present with significantly higher rates of medical complications and mortality compared to general population peers, especially from age 40. The signs/symptoms of COVID‐19 and risk factors for severe disease course are similar to the general population. Those with dementia are at even greater risk, despite being younger than typical patients with AD. Individuals with Down syndrome should be prioritised for SARS‐Cov‐2 vaccination at younger ages than their peers in the general population. | Alzheimers Dement | 2021 | | CORD-19 |
| 3053 | P11-5: Clinical outcomes of hypoxemic, COVID-19 confirmed patients on high-flow nasal cannula (HFNC) therapy in a tertiary government hospital in Metro Manila, Philippines: A retrospective study | Respirology | 2021 | | CORD-19 |
| 3054 | Spousal dementia caregivers' use of technology during the COVID-19 global pandemic: Lessons learned from the NYU family support program BACKGROUND: Daily routines have been drastically impacted by COVID‐19, including healthcare appointments, home services, and many recreational opportunities. Spousal dementia caregivers (CGs) are particularly vulnerable during COVID‐19, as many rely on family members, daycare, in‐home assistance, and other respite opportunities. We conducted qualitative interviews in May/June 2020 to understand the impact of COVID‐19 on dementia CGs and how they experienced the switch of all the NYU ADRD Family Support Program (FSP) services to telehealth. METHOD: A total of 10 spousal CGs participated in videoconference interviews about their COVID‐19 experiences and the FSP’s transition to the telehealth format. Semi‐structured interviews were conducted by one of two interviewers who were external to the FSP to encourage freedom of discussion. All sessions were recorded and transcribed. De‐identified transcripts were coded by two independent coders using NVivo, with discrepancies resolved by a third researcher. RESULT: CGs ranged in age from 54 to 86; 7 were female, 8 were non‐Hispanic White, and 2 were Black. All were New York City residents living with the person with dementia; 2 households had additional adult family members. Qualitative analysis revealed several major themes related to COVID‐19 experiences: fears surrounding COVID‐19 and staying healthy; changes in daily routines; the impact of reduced respite and support services; adaptation to technology that enabled increased contact with family/friends. Feedback about the telehealth adaptation of the FSP included observations about new group dynamics and decreased barriers to involvement due to the ability to participate from home, reducing the need for transportation and other logistics related to traveling. CONCLUSION: Despite significant challenges due to COVID‐19, CGs reported benefit and support from the FSP in the new telehealth format. One participant described the FSP as “indispensable” and expressed how much members relied on each other during COVID‐19. In addition, we learned that the telehealth FSP not only served as a source of support during the crisis but that there were perceived advantages to this format, including reductions in barriers to in‐person services (finding transportation, travel time, getting respite care for the person with dementia). We recommend continuing the option of telehealth services for dementia CGs after the COVID‐19 crisis. | Alzheimers Dement | 2022 | | CORD-19 |
| 3055 | P5-23: Neurological complications of patients with COVID-19 | Respirology | 2021 | | CORD-19 |
| 3056 | Tau-load in the lingual gyrus impacts anxiety levels during the COVID-19 pandemic in participants of longitudinal observational studies in aging BACKGROUND: By obtaining a better grasp on the impact of the COVID‐19 pandemic on individuals with cognitive impairment, this knowledge could be used to improve the delivery of information to this particular group. We aimed to assess the relationship between tau deposition and the change in anxiety levels, before and during the pandemic. We hypothesized that since the pandemic, higher tau loads would lower the change in anxiety. Furthermore, we expected these anxiety levels not to be associated with COVID‐19 related stress in participants with cognitive decline. METHODS: 63 participants of the Translational Biomarker of Aging and Dementia (TRIAD) cohort (cognitively healthy, N=38; cognitively impaired, N=25, of which 7 had dementia due to Alzheimer’s disease), were assessed to evaluate their individual change in anxiety levels (GAD‐7). This was done at three different timepoints, of which the latest fell during the COVID‐19 lockdown period. Two rates of change, one before and one during the pandemic, were determined using the following definition: (next timepoint – current timepoint)/time difference. In addition, at the latest timepoint, subjective stress due to COVID‐19 was measured using the Montreal Assessment of Stress related to COVID‐19 (MASC). To assess the levels of tau, standard uptake value ratios (SUVR) from previously obtained [18F]MK‐6240 PET‐scans were used. RESULTS: [18F]MK‐6240 tracer binding in the lingual gyrus was negatively associated with the rate of change in GAD‐7 scores after correcting for age, sex, years of education and the presence of APOE ε4, but only in cognitively impaired individuals during the pandemic (fig 1A). In addition, the GAD‐7 score at the latest timepoint was associated with stress related to COVID‐19, but only in cognitively healthy individuals (fig 1B and 1C). CONCLUSIONS: The presence of tau in the lingual gyrus negatively affected the rate of change in GAD‐7 scores during the COVID‐19 pandemic in individuals with cognitive impairment. This could indicate that information pertaining to the pandemic does not reach these individuals in an efficient manner. The missing association between COVID‐19 induced stress and the latest GAD‐7 scores in these individuals is a further indication of this. | Alzheimers Dement | 2021 | | CORD-19 |
| 3057 | Impact of an intergenerational training program in the use of information and communication technologies for older adults who receive cognitive intervention in the context of a Covid-19 pandemic: Preliminary results BACKGROUND: Worldwide, the Covid‐19 pandemic impacted on professionals and patients receiving cognitive rehabilitation (CR) forcing them to instrument assistance programs through tele‐neuropsychology. Many of those who receive CR are older adults who lack the necessary technological knowledge to carry out CR through teleneuropsychology. The present study aims to evaluate the impact of a training program on technological tools, carried out by high school students, for older adults who received CR through teleneuropsychology. METHOD: Design: Pre‐post, longitudinal intervention study. Participants: Older adults (n=13) (73.34 +/‐ 5.07 years old) and Students (n=20) (16.14 +/‐1.33 years old). The intervention consisted of a 4 week program for technological training. Participants were assessed at the beginning and the end of the program which consists in two training sessions of 45 minutes each. Instruments: Older adults were assessed with: Questionnaire of Social Demographic Data and Use of Technology (built ad. Hoc.), Functional Assessment Questionnaire, MOS Scale of Social Support, Try Your Memory Test (TYM). Students were assessed with: Basic data questionnaire and Negative stereotypes questionnaire towards old age (CENVE). RESULT: When comparing pre and post‐tests, statistically significant differences were found in the assessed variables. In the older adult group, a significant difference was found in the use of zoom platform (z= ‐2.97, p= .003). In the student group, a statistically significant difference was found regarding the beliefs about aging (z=‐2,53 p= .01). CONCLUSION: These results add evidence regarding the importance of applying technology training programs for older adults. Intergenerational programs are a promising alternative where both parts can benefit: older adults through the incorporation of meaningful technological tools for their daily lives, and young participants taking the opportunity to provide community service and to deconstruct negative prejudices and beliefs towards old age and its consequences. | Alzheimers Dement | 2022 | | CORD-19 |
| 3058 | P5-17: The first and second wave of COVID-19 in rural India: A comparison of inflammatory markers with severity of pneumonia | Respirology | 2021 | | CORD-19 |
| 3059 | The impact of the COVID-19 pandemic in exacerbating dementia risk factors in a high-risk Alzheimer's disease population: Study of a cohort with Down syndrome BACKGROUND: The COVID‐19 public health crisis and introduction of strict regulations have presented new challenges for people with Down syndrome (DS) and dementia in the UK. Social and cognitive deprivation together with poor mental health are risk factors for dementia. This study aimed to explore the impact of lockdown on well‐being in a population with DS who are already at high‐risk for developing dementia. METHOD: 98 individuals with DS were interviewed over the phone about how COVID‐19 and restrictions have affected their daily life, mental and physical health as well as attitude to participating in research. 50 interviews were conducted for younger adults (YA) aged 18‐35 and 48 with older adults (OA) aged 36+ and basic statistics were calculated. RESULT: Since the start of the pandemic, two participants have been diagnosed with dementia and three are under investigation for dementia. Five were diagnosed with dementia prior to the pandemic, three of whom have experienced symptoms worsening. A third of the total cohort reported worsening of general health, although not directly caused by a COVID infection. 44% of YA and 32% of OA reported a negative psychological impact, while almost all experienced a significant change in their daily activities with only 47% returning to their physical or social activities at the end of the initial lockdown. Regarding outlook on research participation, over 80% of individuals stated they would still be happy to participate in research in person and 75% would also find research conducted over video call to be a feasible option. CONCLUSION: The pandemic has had a negative impact on physical and mental health of a large proportion of individuals with DS which in turn may potentially affect dementia risk in this already vulnerable group. Although no causal relationship can be established from this study, the aforementioned worsening in health may have partially resulted from the social isolation, reduced physical and cognitive stimulation recorded in this cohort. | Alzheimers Dement | 2022 | | CORD-19 |
| 3060 | Greater psychological resilience during the COVID-19 pandemic is associated with lower tau burden in cognitively unimpaired individuals BACKGROUND: The outbreak of the 2019 novel coronavirus SARS‐CoV‐2, causing the COVID‐19 pandemic, along with the global measures used to control the spread of the disease, have been particularly stressful for older individuals. Robust evidence suggests that stress‐related physiological processes may play a significant role in the onset of age‐related cognitive decline and dementia, such as Alzheimer’s disease (AD). For example, previous animal and human research have shown that stress exacerbates tau pathology and subsequent cognitive impairment. One important factor determining a person’s level of stress is psychological resilience, which refers to a person’s ability to return to equilibrium when difficulties occur. As such, resilience may buffer and protect individuals against the deleterious effects of stress. The objectives of this study were to examine the relationship between psychological resilience and tau burden in cognitively unimpaired individuals, and to evaluate whether amyloid (Aß) pathology modifies this relationship. METHOD: A total of 114 older adults (mean age=74.5;66 females (57.9%)) enrolled in the Harvard Aging Brain Study or the Instrumental Activities of Daily Living study completed an electronic survey online including measures of psychological resilience (Connor‐Davidson Resilience Scale‐10, where a higher score indicates greater resilience) during the COVID‐19 pandemic period (May 2020). We used previously collected (mean time from survey=1.75 year) PET imaging data to assess Aß and tau burden. RESULTS: Overall, participants demonstrated high levels of resilience (mean=29.5,range=9‐40). Multiple regression analyses (correcting for age, gender and time difference between survey and PET) demonstrated an interaction between resilience and amyloid on tau pathology (ß=‐0.01,p=0.015, Figure1). Specifically, in Aß+ individuals (SUVR>1.324), those with higher psychological resilience also had lower tau pathology. No relationship was seen in Aß‐ individuals. CONCLUSION: Our findings suggest that greater resilience during the pandemic is associated with lower tau burden in individuals at higher risk of cognitive decline (i.e. preclinical AD). Future studies are needed to determine the impact of stress and psychological resilience on prospective pathological brain changes and subsequent cognitive decline. Furthermore, resilience may be an important target for interventions to support older adults navigating stressful situations and to lessen the influence of stressors on AD pathological processes. | Alzheimers Dement | 2021 | | CORD-19 |
| 3061 | Quality of life of Alzheimer's disease patients during the Covid-19 pandemic January-December 2020 at the National Brain Center Hospital in Jakarta, Indonesia BACKGROUND: During the Covid‐19 pandemic, new habit adaptations applied. This affects the Alzheimer’s Disease patients quality of life who went to our Memory Clinic from January – December 2020. METHOD: This study aims to describe the quality of life of Alzheimer's Disease patients based on 13 questions from the QOL‐AD questionnaire filled by the patient's family. A descriptive cross‐sectional study using QOL‐AD questionnaire google form sent by Whatsapp to 42 Alzheimer's disease patients, which was filled by the patient's family. Data collected in the form of gender, age, latest education level, MMSE score and MOCA‐INA score. RESULT: From 42 Alzheimer's Disease patients, 24 patient families (57%) responded to the questionnaire. Obtained 10 male (42%) and 14 female (58%) patients, age range 40‐50 years 1 person (4%), 51‐60 years 4 people (17%), 61‐ 70 years 8 people (33%), 71 ‐ 80 years 8 people (33%) and> 80 years 3 people (13%), education level <6 years 3 people (13%), 6‐9 years 2 people (8 %), 10‐12 years 11 people (46%) and> 12 years 8 people (33%), MMSE scores 0‐16 20 people (83%), 17‐23 4 people (17%) and 24‐30 0 people (0%) and MOCA‐INA scores 0‐17 23 people (96%), 18‐25 0 people (0%) and 26‐30 1 people (4%). Quality of life based on gender, age, education level, MMSE score and MOCA‐INA score, the most poor quality is found in the memory of 19 people (79%), the most fair quality is in the finances of 19 people (79%), the most good quality is in marriage with 13 people (54%) and the most excellent quality is in the marriage of 2 people (9 %). CONCLUSION: The quality of life of Alzheimer's Disease patients at National Brain Center Hospital during pandemic Covid‐19 is poor to fair. | Alzheimers Dement | 2022 | | CORD-19 |
| 3062 | Preliminary results from the COVID caregiving project BACKGROUND: In the United States, family caregivers are the cornerstone of the support system for persons living with dementia (PLWD). This study examined how the coronavirus disease 2019 (COVID‐19) pandemic challenged caregivers’ capacity to deliver long term care services and supports to PLWD. METHOD: Participants (expected N=40) in this qualitative study are family caregivers for PLWD who reside in either the community or a long‐term care facility. Family caregivers participate in semi‐structured, hour‐long telephonic interviews covering: (1) adequacy of caregiving supports; (2) social, emotional, physical, financial, and other effects of caregiving during the COVID‐19 pandemic on the caregiver; and (3) effects of the COVID‐19 pandemic on the person with dementia. Interviews are audio‐recorded, transcribed, and coded in NVivo. The University of Pennsylvania IRB approved this study. RESULTS: Preliminary results show that social distancing measures disrupted services and supports for PLWD (e.g., closure of adult day centers). Efforts to minimize the risk of COVID‐19 disease or death for the person with dementia increased caregiver work and feelings of burden. Many caregivers described making difficult tradeoffs. Some reduced their utilization of supports (e.g., forgoing having paid aides come into the home, limiting visits from other family members), but this has increased workload and limited opportunities for respite. Other caregivers reduced work hours or left the workforce entirely (e.g., because they deemed their risk of SARS‐CoV‐2 exposure on the job too high), but this has increased financial vulnerability and social isolation. A majority of caregivers expressed concern that social distancing has negatively affected the person in their care; many perceive a hastening of cognitive decline and feel their time with the person with dementia has been limited by the pandemic. Caregivers for long‐term care facility residents reported frustration with limited visitation opportunities as well as a perceived decrease in quality of care and lack of transparency. CONCLUSION: Our results will help characterize the impact of the COVID‐19 pandemic on PLWD and their caregivers. They will inform ethical guidelines and policies to improve the delivery of services and supports for PLWD and the ability of people to perform the work of caregiving. | Alzheimers Dement | 2022 | | CORD-19 |
| 3063 | P4-25: The dynamics of the quality of life of healthy people amid the COVID-19 pandemic when soy and pumpkin products are included in the diet | Respirology | 2021 | | CORD-19 |
| 3064 | TMS induced EEG perturbation as a marker of psychological resilience to deleterious mental health effects during the COVID-19 pandemic BACKGROUND: Social, economic and psychological hardships associated with the COVID‐19 pandemic are expected to result in a global burden on mental health outcomes. However, while some individuals suffer from increasing distress and reduced quality of life, others will show no negative effects. A better understanding of brain mechanisms subtending resilience would be helpful in informing future recommendations to individuals and societies facing the present pandemic and future similar events. Here, we compared neurophysiological brain markers between individuals who exhibited resilience or vulnerability to pandemic associated psychological stress. METHOD: 23 participants from the longitudinal study cohort of the Barcelona Brain Health Initiative (Cattaneo et al., Front. Aging Neurosci. 2018;10:321) who underwent concurrent transcranial magnetic stimulation with electroencephalography (TMS‐EEG), were classified as either resilient (n=16) or non‐resilient (n=7), based on their scoring in the PHQ‐4 questionnaire (Kroenke et al., Psychosomatics 2009;50(6):613–21) along four timepoints; one before COVID‐19 outbreak and three spanning 2.5 months during the pandemic. Individuals maintaining a score below 3 across all timepoints were deemed resilient, while those scoring below 3 before pandemic but higher than 2 at any pandemic timepoint were considered non‐resilient. TMS‐EEG data was collected by delivering 120 single TMS pulses to the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobule (IPL). TMS evoked global mean field amplitude and local response at the stimulation site were computed. RESULT: Figure 1 depicts time‐series for DLPFC and IPL responses for both groups of subjects. Overall, non‐resilient individuals exhibited a larger global response to TMS perturbation during DLPFC stimulation, as well as larger local current density estimates during IPL stimulation. CONCLUSION: These preliminary results revealed that non‐resilient individuals were more susceptible to TMS perturbation, shown by global DLPFC and local IPL reactivity. Notably, these targets are nodes of the default mode and cognitive control networks affected by stress (van Oort et al., Neurosci. Biobehav. Rev. 2017;83:281–97), and the left frontal cortex has been proposed as a cognitive resilience hub (Franzmeier et al., J. Alzheimer’s Dis. 2017;59(4):1381–92.). Future studies should investigate and confirm the possibility that these nodes constitute a shared neurophysiological substrate for psychological and cognitive resilience. | Alzheimers Dement | 2021 | | CORD-19 |
| 3065 | U.S. POINTER: Lessons learned about delivery of a multi-domain lifestyle intervention during the COVID-19 pandemic BACKGROUND: U.S. POINTER is testing whether multidomain lifestyle interventions focused on physical exercise, nutrition, cognitive challenge, and risk factor management reduces risk of cognitive decline in a heterogeneous population of at‐risk older adults in America. The study adapts the FINGER (Finnish Intervention Geriatric Study to Prevent Cognitive Impairment and Disability) interventions to fit the United States culture and delivers the intervention within the community at 5 sites across the country. METHOD: U.S. POINTER is a 2‐year RCT that will enroll 2000 cognitively unimpaired older adults who are at risk for cognitive decline due sedentary lifestyle, poor diet and other factors. Participants are randomized to one of two lifestyle intervention groups that differ in format and intensity. In 2020, the COVID‐19 pandemic presented a number of challenges for the study that affected recruitment, assessment schedules, and intervention delivery. RESULT: As of March 2020, when COVID‐19 incidence was on an exponential rise in the US, 240 participants had been enrolled in U.S. POINTER. In response to local and national safety mandates, study activities were paused from March 23(rd) to July 13(th). During the pause, sites remained in contact with study candidates and enrolled participants to provide ongoing support to keep them engaged in the trial. Enrollees also received regular telephone calls to encourage continued adherence to their assigned lifestyle intervention. In response to the multiple pandemic‐related challenges, study protocols and procedures were adapted to facilitate and encourage participant adherence to intervention activities. At study re‐start, retention was 98%. Despite climbing COVID‐19 infection rates nationwide, enrollment at all 5 sites has continued at a steady rate (N=540 as of Jan2021), virtual Team Meeting attendance for both lifestyle groups exceeds 80%, and participants continue to successfully work toward their intervention goals. CONCLUSION: The COVID‐19 pandemic presented unprecedented challenges, but it also provided a unique opportunity to adapt intervention delivery so that a nonpharmacological community‐based trial could continue – even during a debilitating global health crisis. U.S. POINTER’s adaptations to pandemic‐related challenges may ultimately increase the resilience of its interventions to even the most challenging of circumstances that older adults will face now and in the future. | Alzheimers Dement | 2021 | | CORD-19 |
| 3066 | The Impacts of Trade Restrictions on World Agricultural Price Volatility during the COVID-19 Pandemic During the COVID‐19 pandemic, countries applied trade restrictions to insulate their domestic markets from the world market. However, these trade policies could have amplified international market price fluctuations. This paper explores the effects of trade restrictions on international agricultural price volatility. A theoretical model is developed to quantify how trade policies amplify the initial shock. Using panel data covering 71 countries from January 2020 to July 2021, we examine empirically the effects of trade policies on world agricultural price volatility. The results show that trade distortions further induced volatility of world agricultural prices by around 22 percent during the COVID‐19 pandemic. The multiplier effects are much more substantial in agricultural exporting countries than in importing countries. Large countries like China and the US could make significant contributions to stabilizing world prices by limiting the extent of unilateral trade policy interventions. | N/A | 2021 | | CORD-19 |
| 3067 | Vaccination beliefs in older African Americans in Detroit during the Covid-19 pandemic BACKGROUND: The COVID‐19 pandemic has devastated multiple Countries targeting vulnerable populations. In Michigan there have been over 550,000 confirmed cases and over 14,000 deaths that forced health officials to rapidly develop and distribute COVID‐19 vaccines (MDHHS, 2021). As researchers study the COVID‐19 virus and vaccines, it is important to understand the educational needs of the public in deciding intent to accept the vaccine. METHOD: We analyzed factors correlated with generalized anxiety rates in 150 African Americans age 65 and older, recruited from Wayne State Institute of Gerontology Healthier Black Elders Center and surrounding communities. Participants completed telephone questionnaires measuring demographics, stressors associated with COVID‐19 pandemic, and emotions. A scale was designed using the Health Belief Model assessing beliefs, susceptibility, severity, conspiracy beliefs of Covid‐19 (man‐made), and intent to be vaccinated. Applying factor analysis, questions were divided into: fear of COVID‐19 (I am worried about the likelihood of getting COVID‐19, My chances of getting COVID‐19 in next few months is great, I will be very sick if I get COVID‐19, Vaccinations decrease chances of infections or complications, I will get the vaccine if I receive adequate information), vaccination safety (I am concerned the vaccine will not work, I am concerned the vaccine will not be safe, Side effects from the vaccine interfere with activities and, Vaccinations make me less worried). Participants responded to these questions on 5‐point Likert scale (from “Strongly Disagree” to “Strongly Agree”). RESULT: Of 150 participants, 67% expressed intention to get vaccinated while only 15% were reluctant to vaccinate. Stepwise regression analysis showed that fear of COVID‐19 and vaccination safety explained 49% variance of intent to vaccinate. Vaccination safety was predicted by age, loneliness, vulnerability, and positive emotions (R(2) = 20%). Fear of COVID‐19 was predicted by anxiety and positive emotions (R(2) = 8%). CONCLUSION: This study provides a snapshot of urban African American older adults who are generally eager to get vaccinated for COVID‐19, and predictors of intent to get vaccinated. More research is needed to understand the scope of educational needs to increase the likelihood of older African Americans to get vaccinated. | Alzheimers Dement | 2021 | | CORD-19 |
| 3068 | P5-59: Comparative analysis of the course of post-COVID-19 syndrome in individuals of different age groups Laboratory methods: in the first group, 27.1% had moderate leukocytosis, in the second group, the percentage of patients with leukocytosis was 62.5;in the biochemical analysis of blood in the first group, 57.6% had increased transaminases, in the second group, 87.5%. P5-59: Comparative analysis of the course of post-COVID-19 syndrome in individuals of different age groups 1 Amur State Medical Academy, Russia B Background and Aims b : A comparative analysis of the course of Post-COVID-19 syndrome in individuals of different age categories. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 3069 | P5-108: The association between awake prone positioning and mortality in COVID-19 patients | Respirology | 2021 | | CORD-19 |
| 3070 | P11-13: Diffuse pulmonary hemorrhage, a catastrophic outcome of a 57-year-old venezuelan, with COVID-19 pneumonia, who developed multiple thrombosis and aman-variant GBS | Respirology | 2021 | | CORD-19 |
| 3071 | Covid-19 pandemic: A curse and a blessing for informal dementia caregivers-A qualitative study BACKGROUND: Caring for a relative or friend who lives with dementia is a complex and demanding process that affects the quality of life and the well‐being of the informal caregivers. Many previous studies show that informal dementia caregivers experience high levels of stress, psychological burden, and depression due to the demands of caregiving which include changes in one's personal and professional life, self‐neglect, and withdrawal from pleasurable activities. The COVID‐19 pandemic drastically changed people's lives and everyday interactions and the limited number of studies on this topic shows that it introduced additional challenges for dementia caregivers. These challenges include protecting themselves and the person they care for from infection, managing the behavioural and psychological symptoms of the disease, introducing changes in everyday routines, dealing with quarantine or isolation. METHOD: The aim of this study was to gain a better insight into the experiences of informal dementia caregivers during the COVID‐19 pandemic. Semi‐structured interviews were conducted in the period of July‐September with nine participants from different countries and the data were analyzed using inductive thematic analysis resulting in extraction of five themes. RESULTS: The results show that informal caregivers experience worsening of the behavioural and psychological symptoms of the person they care for, limited access to the institutions and the person they care for, fear of infection but also more free time for looking after the person with dementia. CONCLUSION: This was one of the first qualitative research aimed to understand the unique experiences of informal dementia caregivers during the COVID‐19 pandemic, and the first research ever that has included caregivers from North Macedonia. The results show that informal dementia caregivers experience additional burden and challenges due to the COVID‐19 pandemic which adds to their existing psychological distress. This can further compromise their health and well‐being, and result in lower quality of life for them and the person with dementia and requires more focused attention from the relevant medical and social services. It should also be taken into consideration when constructing policies for dementia management and formal support during the times of the pandemic. | Alzheimers Dement | 2022 | | CORD-19 |
| 3072 | P1-9: Predictive factor of high-flow nasal oxygen failure in COVID-19 patients at tertiary hospital in Jakarta | Respirology | 2021 | | CORD-19 |
| 3073 | P5-76: Prolonged viral clearance in COVID-19 patients treated with tocilizumab | Respirology | 2021 | | CORD-19 |
| 3074 | P5-31: High prevalence of silent hypoxia among patients with COVID-19 warrants screening for oxyhemoglobin desaturation among patients with fever, cough or dyspnea | Respirology | 2021 | | CORD-19 |
| 3075 | P5-142: A case series on corticosteroid use in COVID-19 patients who suffered from chronic lung disease | Respirology | 2021 | | CORD-19 |
| 3076 | P5-37: Community-acquired respiratory virus cases mimic COVID-19 on lung computed tomography | Respirology | 2021 | | CORD-19 |
| 3077 | P5-152: Familial ciclesonide-responsive cases of COVID-19 pneumonia | Respirology | 2021 | | CORD-19 |
| 3078 | O6-3: Bioinformatics analysis of high-throughput sequencing to identify key genes and signaling pathways in vero E6 cells infected by SARS-CoV-2 We aim to study the biological changes of SARS-CoV-2 infected Vero cells using high-throughput sequencing data, which will be helpful for vaccine development and drug screening. O6-3: Bioinformatics analysis of high-throughput sequencing to identify key genes and signaling pathways in vero E6 cells infected by SARS-CoV-2 Cytoscape 3.7.2 was applied for the visualization of the protein-protein interaction network and the identification of the hub genes. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 3079 | Features of the provision of inpatient medical care to patients with Alzheimer's disease during the SARS-COVID-19 pandemic BACKGROUND: With Alzheimer's disease, the patient is not only unable to help himself, but he cannot even ask for such help. This is especially dangerous for a patient during the SARS‐COVID‐19 pandemic. Since the deadly complications of SARS‐COVID‐19 are observed in the age group in which Alzheimer's disease manifests itself. METHOD: We observed 26 women aged 71‐84 with Alzheimer's disease. All patients received treatment according to Alzheimer's disease treatment standards. Both amyloid‐beta and tau were found in their cerebrospinal fluid. They also showed neurodegeneration in the areas classic for Alzheimer's disease on MRI of the brain. During a pandemic, sickness departments must wear masks and change them every 4 hours to prevent SARS‐COVID‐19 disease. In patients with Alzheimer's disease, the fulfillment of these requirements on their own is impracticable, since they have memory disorders for current events, changes in mood (apathy). Therefore, constant monitoring of medical personnel for compliance with these requirements is required. These patients in all inpatient care periods were given masks with a built‐in 4‐hour timer and a sensor that responded to opening contacts when the mask was removed. The end of 4 hours of wearing the mask and the removal of the mask as indicated by sound and light alarms installed in the mask. RESULT: This greatly facilitated the monitoring of compliance with quarantine SARS‐COVID‐19 measures in patients with Alzheimer's disease. Also, the timely change of the mask was the prevention of hypoxia that develops as a result of wetting the mask with prolonged wearing. CONCLUSION: Prevention of hypoxia with the prolonged wearing of a wet mask alleviates the symptoms of Alzheimer's disease, allows the patient to convey their thoughts and feelings, and significantly improves the quality of life of patients. | Alzheimers Dement | 2022 | | CORD-19 |
| 3080 | P5-60: Clinical and radiological features of COVID-19 in pregnant women: A case-control study | Respirology | 2021 | | CORD-19 |
| 3081 | P5-89: Effectiveness of a questionnaire to screen COVID-19 | Respirology | 2021 | | CORD-19 |
| 3082 | COVID-19 and cognitive impairment in the elderly: A literature review BACKGROUND: COVID‐19 was declared a pandemic by the World Health Organization on the 11th of March 2020, and it represents an unprecedented immediate and persistent threat to our health care systems. Emerging data reveals neurological symptoms and subclinical cognitive dysfunction and the development of dementia or worsening of it coming to light in the elderly. METHOD: An exhaustive search of scientific publications, which included original articles and reports was conducted using the online search databases like Pub Med, with search terms used being neurologic manifestations of COVID‐19, neurological complications of novel coronavirus 2019, with relevant articles analyzed for a possible neurological syndrome related to COVID‐19. Based on specific selection criteria the relationship between COVID‐19 and the nervous system was established and a brief narrative literature review was done. RESULT: There has been convincing evidence that SARS‐CoV‐2, the etiologic agent of COVID‐19 can affect the nervous system with consequent damage and neurologic alterations with causation of cognitive decline and worsening of dementia in the elderly survivors. CONCLUSION: Based on evidence gathered from scientific literature, this review raises a possibility of nervous system involvement in COVID‐19 with progression to dementia or worsening of existing Dementia especially in the elderly patients. Longitudinal neurological assessments of patients after recovery will be crucial in understanding the natural History of COVID‐19 in the CNS and monitoring for potential neurologic sequalae and long‐term effects on causation and worsening of dementia. The literature review also states the need to start investigating the mechanistic link between Alzheimer's disease and COVID‐19 for further follow up. | Alzheimers Dement | 2021 | | CORD-19 |
| 3083 | Impact of Covid-19 pandemic on lifestyle in a middle-aged and elderly population BACKGROUND: Mandated lockdowns and restricted activity in response to the COVID‐19 pandemic has affected our everyday life(1). Seniors, in particular, have been affected due to higher morbidity and mortality(2). The World‐Wide‐FINGERS‐SARS‐CoV‐2 survey is part of an international project, consisting of members of the World‐Wide FINGERS (WW‐FINGERS) Network for dementia risk reduction and prevention(3). The study aims to measure the direct and indirect effects of the outbreak in midlife and older age. Preliminary results of this ongoing study is focused on lifestyle changes. METHOD: The survey commenced in September 2020.Participants aged 45 and above were recruited from existing research cohorts, memory clinic patients and community subjects. Sociodemographic factors, health related information, impact on lifestyle and behavior as well as personality factors were collected through three modalities: self‐administered online survey, telephone survey and in person with research staff. RESULT: At present, 167 non‐demented participants were included in the current preliminary analysis. Majority of the participants were Chinese (83.2%), aged 65 and above (59.3%), male (58.1%), with at least secondary education (80.8%). The survey found that 61.6% of the participants reported decreased contact with friends and relatives, with 22.2% reporting an increase in loneliness. Approximately one‐third of the participants reported a decrease in physical activity (35.9%) and an increase in food intake (30.5% in snacking habits; 25.1% in fruits consumption). Approximately half of the participants reported increase in usage of internet and digital services to keep in contact with family and friends. CONCLUSION: The COVID‐19 pandemic has produced measurable impacts on lifestyle‐related behavior of individuals. The decrease in social interaction and increase in loneliness during the pandemic due to government directive, along with concerns of contracting the virus highlight the importance of digital services for and digital literacy in older adults to keep them connected and supported remotely. | Alzheimers Dement | 2021 | | CORD-19 |
| 3084 | Impact of COVID-19 and imposed lockdown on presenting complaints of persons with dementia and challenges faced by caregivers in India BACKGROUND: A diagnosis of dementia increases the vulnerability of an already vulnerable older adult population. COVID‐19 infection and the imposed lockdown have both had a huge impact on the lives of persons with dementia and their caregivers. The aim of this study is to evaluate presenting complaints provided by caregivers in the COVID‐19‐context in India. METHOD: We examined the case records of persons with dementia who presented at theDementia Care in SCARF (DEMCARES), an outpatient clinic in Chennai between May 2020 and April 2021 during the COVID‐19 pandemic. We reviewed their presenting complaints to look for ones specific to the COVID‐19 context and identified caregiver challenges. RESULT: COVID‐19 infection was reported by caregivers to affect the cognition and functioning of their relatives with dementia. The impact of imposed lockdown was observed through reports of caregivers noticing initial signs of dementia following the increased social isolation experienced by their loved ones during the pandemic. Some of the challenges faced by caregivers included their relative with dementia’s inability to understand the gravity of the COVID‐19 situation, wanting to step out of the house and inability to do so contributing to restlessness, agitation and aggression. CONCLUSION: Caregivers are increasingly facing challenges posed by behavioral and psychological symptoms of dementia stemming from the imposed lockdown restrictions. Teleconsultation and virtual delivery of dementia‐specific interventions could potentially help caregivers overcome some of these challenges. Older persons at risk for social isolation and those recovering from COVID‐19 should be screened for dementia. General and primary care physicians should actively watch out for signs of cognitive impairment and make necessary referrals as early detection of dementia in elderly persons recovering from COVID‐19 may improve outcomes. | Alzheimers Dement | 2022 | | CORD-19 |
| 3085 | Telehealth-based assessment of cognition in older adults during COVID-19 and beyond BACKGROUND: Evidence supporting the use of telehealth techniques in the assessment and diagnosis of dementia has been growing steadily. This began with the use of telephone‐based cognitive screening in the 1980s and televideoconference‐based assessments in the 2000s. The COVID19 pandemic brought telehealth suddenly to the forefront of healthcare, particularly for aging and at‐risk populations, as well as for clinical providers and researchers. While clinicians have been challenged to continue to provide patient care in a safe manner, researchers have been faced with the challenge of maintaining study protocols and continuing to advance the science of dementia. Fortunately, a growing body of research has demonstrated the feasibility, reliability, validity, and consumer acceptability of telehealth‐based assessment procedures, including teleneuropsychological (teleNP) techniques. METHOD: We first reported results from a study of 202 adults age 50‐85 using a brief battery of common neuropsychological tests administered via teleNP vs in‐person in counterbalanced fashion which showed generally strong intraclass correlations (Cullum et al., 2014). Additional studies have since examined the validity and consumer acceptability of teleNP assessment in older adults, including recent reviews and findings from surveys and observations using teleNP during the COVID19 pandemic. RESULT: Our initial investigation revealed essentially equivalent results across teleNP vs traditional in‐person test conditions, with intraclass correlations around .80 and high levels of satisfaction with the procedures. Additional findings revealed validity by the discrimination of impaired and non‐impaired older adults with and without cognitive impairment similar to traditional in‐person assessment. Subsequent studies and reviews have added to this growing body of literature supporting the use of teleNP in older adults. CONCLUSION: In this presentation, the literature supporting the evidence for telehealth applications in the assessment and diagnosis of dementia will be reviewed, along with commonly used assessment instruments. A critical review of the strengths and limitations of remote clinical/cognitive evaluations as applied to aging individuals with and without cognitive impairment will be provided, along with practical recommendations for application of these procedures, including in‐home and computerized evaluations. Last, needs, opportunities, and future directions for remote cognitive assessment in clinical and research settings, including large‐scale surveillance and treatment studies, will be discussed. | Alzheimers Dement | 2021 | | CORD-19 |
| 3086 | P5-95: Complete heart block and neutropenia due to SARS-coronavirus-2 in a patient with chronic lymphocytic leukemia-Misery of an elderly gentleman 1 Senior Clinical Fellow in Respiratory Medicine, Chorley and South Ribble Hospital, UK, 2 Ju... B Introduction b : Different complications of COVID 19 have been described. P5-95: Complete heart block and neutropenia due to SARS - Corona virus-2 in a patient with chronic lymphocytic leukemia - Misery of an elderly gentleman As he was bradycardic he was investigated with an ECG which showed new onset complete heart block. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 3087 | P5-20: The prevalence of comorbid respiratory disease among COVID-19 patients and mortality during the first wave in Japan: A nationwide survey by the Japanese Respiratory Society | Respirology | 2021 | | CORD-19 |
| 3088 | Leveraging videoconferencing supports the continuity of Alzheimer research during the COVID-19 pandemic and beyond BACKGROUND: The COVID‐19 pandemic has placed a demand on researchers to limit in‐person contact with participants, greatly impacting Alzheimer Disease (AD) research. To address this problem, we describe here an approach to using digital technology to continue nationwide clinical recruitment and ascertainment of biological samples while adhering to COVID‐19 guidelines and travel restrictions. METHOD: To accomplish this, we considered a videoconferencing approach for remote delivery of cognitive assessments. A multi‐site panel of neurologists and clinical psychologists and a detailed literature review ensured a protocol that captures the best‐practices for administering assessments through videoconferencing while ensuring consistency between remote and in‐person administration. Clinical coordinators underwent training to ensure good agreement with in‐person administration. Most aspects of the cognitive assessments easily transferred to videoconferencing, though Trail Making A and B, and Digit Symbol‐Coding were removed to protect the integrity of the evaluation. Additionally, we coordinated the collection of biological samples with a national company, Quest Diagnostics, to provide phlebotomy services at the participant’s residence. All protocols were developed under the guidance of the Human Subjects Research Office at the University of Miami and with approval of local IRB. RESULT: Our clinical coordinators completed over two dozen remote assessments using these protocols. Both cases and controls were enrolled, across various ethnic populations within our study. The distributions of age and 3MS were similar between in‐person and remote assessments. The uptake of videoconferencing enrollment varied among the age groups, level of impairment, at‐home support system and telemedicine readiness. For example, earlier‐onset groups had the best uptake, while older‐onset groups showed the least uptake due to a higher prevalence of telemedicine unreadiness (Lam et al., 2020; Bossen et al.,2015). CONCLUSION: This study demonstrates that remote enrollment and ascertainment of biological samples through videoconferencing and partnering with national mobile phlebotomy services is feasible. This approach allows researchers to continue ascertainment efforts while maintaining their participants’ autonomy through informed consent and privacy throughout the process and minimizing their exposure to COVID‐19. | Alzheimers Dement | 2021 | | CORD-19 |
| 3089 | P5-113: Baseline characteristics, clinical course and outcomes of COVID-19 confirmed healthcare workers in the University of Santo Tomas Hospital | Respirology | 2021 | | CORD-19 |
| 3090 | Exploring older adults' experiences using technology during a viral pandemic BACKGROUND: Older adults are at greater risk for morbidity and mortality associated with COVID‐19. Spatial distancing and sequestering practices are recommended to limit viral exposure. Older adults adopting these practices are at increased risk of social isolation and adverse health outcomes. Remote technologies offer various platforms for satisfying socialization and healthcare needs while sequestering. Understanding how older adults are using technology has implications for wellbeing during a pandemic. METHOD: Researchers attempted to contact all participants enrolled in the University of Kentucky Alzheimer's Disease Research Center longitudinal study via telephone to survey technology use (n = 706). Participants were contacted directly, except for demented participants, whose primary caregivers were contacted to respond on their behalf, when possible. Participants and caregivers gave their assent verbally to complete the voluntary survey, the procedures of which were approved by the IRB. The surveys consisted of validated instruments to gauge the extent of use of and comfort with technology. Spearman correlations, chi‐square tests, and t‐tests were used to explore data. RESULT: Ultimately, 384 participants were reached and 332 consented to participate. Most reported reliable home internet access (91.5%) and some internet use (90.6%). Recent feelings of loneliness were not related to any technology‐related variables (all ps > 0.29) other than decreasing with greater willingness to use telehealth (Rho = ‐0.11, p = 0.06). Those who reported a lack of comfort with technology (n = 76) were less likely to text messaging (67% vs 78%) and social media (56% vs 69%), ps ≤ 0.06, but felt socially connected using technology at similar levels (82% vs 75%), p = 0.22. Nearly 70% of this group reported they would use technology more with training. Across all participants, willingness to use telehealth was not related to frequency of frustration with tech (Rho = 0, p = 0.99). CONCLUSION: The results suggest that some older adults’ use of technology is limited by familiarity. Lack of familiarity does not appear to create a barrier to using telehealth nor does frustration with technology appear to limit telehealth use. The findings have implications for supporting older adults sequestered during a pandemic but potentially more broadly. | Alzheimers Dement | 2022 | | CORD-19 |
| 3091 | P5-19: Spontaneous pneumothorax in Indonesian COVID-19 patients: A retrospective case series | Respirology | 2021 | | CORD-19 |
| 3092 | P5-43: A case of hyperpyrexia of hypothalamic origin associated with severe COVID-19 pneumonia in pregnancy | Respirology | 2021 | | CORD-19 |
| 3093 | P4-22: The effect and safety of ultraviolet germicidal irradiation on reusing N95 filtering facepiece respirators at weekly intervals 1 Department of Respiratory Medicine, Kyorin University School of Medicine, Japan, 2 Departme... B Background and Aims b : Under pandemic condition of coronavirus disease 2019, N95 filtering facepiece respirators (N95 respirators) are lacking in many countries. P4-22: The effect and safety of ultraviolet germicidal irradiation on reusing N95 filtering facepiece respirators at weekly intervals Considering this background, the Centers for Disease Control and Prevention suggested reusing N95 respirators and referred the decontamination method by using ultraviolet irradiation (UVGI). [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 3094 | P5-57: Comparison of chest HRCT findings between COVID-19 pneumonia and anti-MDA5 antibody-positive interstitial pneumonia by computer-based quantitative CT image analysis | Respirology | 2021 | | CORD-19 |
| 3095 | P6-56: One case of a patient on maintenance dialysis who concurrently suffered from both COVID-19 and a relapse of pulmonary tuberculosis | Respirology | 2021 | | CORD-19 |
| 3096 | Teaching during COVID-19: reflections of early-career science teachers The unique circumstances of the COVID-19 pandemic required that instruction be shifted online through asynchronous, synchronous, or hybrid models of instruction. This created a need for many K-12 teachers to dramatically rethink how teaching and learning occurred in their classrooms. In this study, we investigate the experiences of early-career science teachers who were in their first year of teaching when the pandemic struck. Using a comparative case study and an analytical framework focused on technology-related leader practices, we explore the unique opportunities for technology-based leadership that emerged for early-career teachers during the pandemic. We posit that the circumstances of the COVID-19 pandemic presented novel opportunities for early-career teachers to assume leadership roles that were embedded within the classroom teaching experience, which created unique opportunities for innovation and leadership in teaching. | N/A | 2022 | | CORD-19 |
| 3097 | The Mediating Impact of IT Capabilities on the Association between Dynamic Capabilities and Organizational Agility: The Case of the Jordanian IT Sector This study suggests a novel progression to the current research endeavor by investigating the influence of information technology capabilities on organizational agility. More specifically, this study aims to fill the gaps found in previous studies and contribute to the current state of knowledge of this domain by focusing on the mediating role that IT capabilities play between dynamic capabilities and organizational agility. Toward that end, 270 Jordanian professionals working in supply chain management and operational departments were approached. Data were collected via distrusting a structured questionnaire that includes items assessing dynamic capabilities, IT capabilities, and organizational agility. The results demonstrated that IT capabilities significantly and positively mediated the relationship between resource-based dynamic capability and organizational agility. The study has also discussed several theoretical along with managerial implications of the research. | N/A | 2022 | | CORD-19 |
| 3098 | Design Principles for Shared Digital Twins in Distributed Systems Digital Twins offer considerable potential for cross-company networks. Recent research primarily focuses on using Digital Twins within the limits of a single organization. However, Shared Digital Twins extend application boundaries to cross-company utilization through their ability to act as a hub to share data. This results in the need to consider additional design dimensions which help practitioners design Digital Twins tailored for inter-company use. The article addresses precisely that issue as it investigates how Shared Digital Twins should be designed to achieve business success. For this purpose, the article proposes a set of design principles for Shared Digital Twins stemming from a qualitative interview study with 18 industry experts. The interview study is the primary data source for formulating and evaluating the design principles. | N/A | 2022 | | CORD-19 |
| 3099 | Sclérose en plaques et vaccination anti-Covid-19: étude d'une cohorte de 37 patients Introduction Plusieurs comités d’experts recommandent la vaccination anti-Covid-19 chez les patients suivis pour sclérose en plaques (SEP). Quatre vaccins anti-Covid-19 ont été approuvés au Maroc depuis décembre 2020 dont ChAdOx1-S et BBIBP-CorV. Objectifs Présenter le profil d’effets indésirables aux vaccins anti-Covid-19 ChAdOx1-S et BBIBP-CorV dans une cohorte de patients suivis pour SEP et évaluer le risque immédiat et à 3 mois de poussée. Patients et méthodes Il s’agit d’une étude rétrospective portant sur les patients suivis pour SEP dans notre formation, vaccinés par la 1ère dose du vaccin anti Covid-19 entre février 2021 et juillet 2021. L’étude a été menée à distance, à travers un questionnaire qui a recueilli les données démographiques des patients, les données liées à la maladie, le type de vaccin reçu, les effets indésirables, les symptômes neurologiques et la notion de poussée faisant suite à la vaccination. Résultats Un total de 37 patients ont été inclus dans l’étude avec un âge médian de 42 ans et 68 % de femmes. Un total de 86,5 % avaient une forme rémittente-récurrente et 92 % étaient sous traitements modificateurs de la maladie (DMT). Un total de 59,5 % ont reçu BBIBP-CorV et 40,5 % ont reçu ChAdOx1-S. Les effets indésirables les plus fréquents étaient la fatigue (29,7 %) et la douleur au site d’injection (24,3 %). Un patient (2,7 %) a présenté une poussée à 13jours de la 1re dose. Discussion Dans notre série, les taux d’effets indésirables rapportés étaient inférieurs à ceux rencontrés dans la population générale dans les études phase III. Cela pourrait être dû à la prise de DMT. Nous rapportons un cas isolé de poussée dans les suites de la vaccination, conformément aux données de séries récentes (0,9 à 2,1 %). Conclusion Les vaccins BBIBP-CorV et ChAdOx1-S ont présenté un profil favorable dans notre cohorte. Nos résultats rejoignent les recommandations des comités d’experts de promouvoir la vaccination anti-Covid-19 chez les patients SEP. | Rev Neurol (Paris) | 2022 | | CORD-19 |
| 3100 | CONTROVERSE: je dois modifier la charge thérapeutique de la SEP en période COVID-19: vaccinations et traitements de fond-synthèse Depuis la première vague début 2020, l’épidémie de COVID-19 a bouleversé le fonctionnement de hôpitaux et la prise en charge de nombreux patients atteints de maladies chroniques, dont la sclérose en plaques (SEP). De grandes questions ont été soulevées par l’épidémie concernant les risques des traitements immunosuppresseurs. Les données observationnelles collectées depuis 2 ans ont permis d’identifier des risques spécifiques vis-à-vis des formes graves de COVID-19 et sur l’efficacité vaccinale. Ainsi, certains auteurs ont suggéré d’adapter la prise en charge des patients afin de les réduire, sans toujours disposer de preuve formelle de leur impact. Il est fondamental d’analyser les données et leur niveau de preuve afin de déterminer quelles adaptations de la délivrance des traitements et de la stratégie vaccinale peuvent être proposées en période COVID. En l’absence de preuve, un consensus d’experts doit permettre de déterminer des recommandations utiles en pratique pour optimiser le suivi et la prise en charge des patients atteints de SEP en période COVID. | Rev Neurol (Paris) | 2022 | | CORD-19 |
