| Title | Venue | Year | Impact | Source |
| 2851 | P5-36: Association of C-reactive protein (CRP), serum ferritin and patient outcome in COVID-19 patients in tertiary referral hospital | Respirology | 2021 | | CORD-19 |
| 2852 | 2021: Making COVID-caused changes permanent, for better or worse What started in 2020 — COVID‐19 — continued with a vengeance in 2021, but last year, some of the changes put into place due to the virus became permanent, at least for now. These included relaxations of the rules regarding buprenorphine and methadone, far greater use of telemedicine and other less sanguine changes, such as to‐go alcohol. In the meantime, opioid overdoses continued to go up, this time with the addition of methamphetamine and cocaine. | N/A | 2021 | | CORD-19 |
| 2853 | P5-13: COVID-19 mobile test unit (COMBAT): A novel pharyngeal sampling platform for COVID-19 testing in Malaysia | Respirology | 2021 | | CORD-19 |
| 2854 | P5-148: The correlation between RT-PCR and antibody rapid test in SARS CoV-2 The results of the Chi-Square test to determine the relationship between RT-PCR examination and rapid test generally showed that the p value was <0.05 with OR 2.453 and CI 95% (1.172-5.133). Combined IgG / IgM assays can provide unclear values, unlike molecular tests for Covid-19 (for example, PCR). 1 Pulmonary Disease Study Program Faculty of Medicine Udayana University, Indonesia B Background and Aims b : Coronavirus Disease (Covid)-19 is currently a worldwide pandemic. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 2855 | P5-98: Vitamin D deficiency as a marker of severe COVID-19 course | Respirology | 2021 | | CORD-19 |
| 2856 | P6-12: The cruel dual; SARS-CoV-2 and tuberculosis coinfection, the Sri Lankan experience 80% of patients were newly diagnosed tuberculosis patients while 20% had reinfection or reactivation with one Multi Drug Resistant tuberculosis patient. Tuberculosis, SARS-COV-2 co-infection, causing double burden to the lung is an emerging syndemic. 1 National Hospital for Respiratory Diseases-Welisara, Sri Lanka B Background and Aims b : Tuberculosis, the ancient infection of the lung should not be overlooked while the global health care systems struggle to control the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-COV-2) infection i.e., COVID-19. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.) | Respirology | 2021 | | CORD-19 |
| 2857 | P5-55: What kind of disease has developed in a teenager against the background of a new coronavirus infection? Is it Kawasaki's or Reye's syndrome? | Respirology | 2021 | | CORD-19 |
| 2858 | P16-60: post-COVID-19 organizing pneumonia treated with mycophenolate mofetil | Respirology | 2021 | | CORD-19 |
| 2859 | P7-61: Management & caring for patients of COPD with COVID-19: A current perspective | Respirology | 2021 | | CORD-19 |
| 2860 | P5-149: Investigation of antibody level by the presence or absence of side effects after the new coronavirus vaccine | Respirology | 2021 | | CORD-19 |
| 2861 | O25-1: Increased expression of angiotensin-converting enzyme 2 (ACE2), TMPRSS2 and furin in idiopathic pulmonary fibrosis (IPF) and lymphangioleiomyomatosis (LAM) patients' lung tissue: Implications for COVID -19 | Respirology | 2021 | | CORD-19 |
| 2862 | P5-15: A case of recurred exacerbations and remissions of COVID-19 pneumonia in a patient with b-cell lymphoma undergoing chemotherapy | Respirology | 2021 | | CORD-19 |
| 2863 | Abstract Book for the 3rd European Myeloma Network Meeting | Hemasphere | 2022 | | CORD-19 |
| 2864 | P5-118: Clinical outcomes of diffuse alveolar damage and organising pneumonia in severe COVID-19 infection | Respirology | 2021 | | CORD-19 |
| 2865 | O22-5: Complete pulmonary function profiles of 267 post COVID patients with exertional dyspnea in Bangladesh | Respirology | 2021 | | CORD-19 |
| 2866 | Effects of the COVID-19 pandemic on healthcare and community-based service use for people living with dementia: Perspectives from dementia care professionals BACKGROUND: Dementia care and healthcare delivery systems have changed substantially as a result of the COVID‐19 pandemic (Wang et al., 2020). Experts have identified a number of barriers to health care access for people living with dementia (PLWD) during the pandemic, including difficulty implementing telemedicine practices, discontinuation of home care services, increased caregiver burden and financial hardship (Brown et al., 2020; Greenberg et al., 2020). Assessment of dementia care providers’ perceptions of the change in use of healthcare and community‐based services by PLWD is needed to identify gaps and to improve care for this vulnerable population during the COVID‐19 pandemic. METHODS: We designed an online survey asking about changes to PLWD and caregiver use of 14 healthcare and community‐based services during the COVID‐19 pandemic and about 15 factors that may have contributed to these changes. The survey was distributed to a network of dementia care professionals across the state of Wisconsin between August 28(th) and October 9(th), 2020. RESULT: A total of 102 individuals completed the survey. Most respondents worked in the Wisconsin Department of Health Services dementia care specialist system, were employed by Aging and Disability Resource Centers (53.5%), identified as female, White race and worked in rural settings. Services most frequently reported as no longer in use included senior center programs, adult day programs, and companion/friendly visitor services, while meal delivery was reported as having increased use by PLWD. Factors identified most frequently as barriers to service use included changes in access to caregiver support/respite services, access to natural supports, compassion fatigue/caregiver burnout and both knowledge of and access to technology/virtual tools. CONCLUSION: The results highlight the increased demand for certain services like meal delivery and the need to find alternatives to in‐person enrichment/recreational and caregiver respite opportunities such as senior center and adult day programs that are being used less. Access to and knowledge of technology and increased stress on caregivers and support systems were identified as some of the more frequent barriers to service use, thus allocating resources towards these areas may be particularly impactful towards improving service use for PLWD during the COVID‐19 pandemic. | Alzheimers Dement | 2021 | | CORD-19 |
| 2867 | P5-14: An age-matched comparison between COVID-19 pneumonia and pneumococcal pneumonia cases | Respirology | 2021 | | CORD-19 |
| 2868 | Managing responsive behaviours of care home residents with dementia during the COVID-19 pandemic BACKGROUND: Most care home residents with dementia exhibit responsive behaviours including aggression, agitation and wandering (Cerejeira et al., 2012). Psychotropic drugs are often prescribed to manage responsive behaviours but contravene guidance as they increase the rate of strokes and death in people with dementia (Gustafsson et al., 2013). However, the use of psychotropic drugs for behaviour management may potentially increase during the COVID‐19 pandemic (Howard et al., 2020). Therefore, it is imperative to understand how responsive behaviours are managed to identify facilitators and barriers to implementing non‐pharmacological approaches. METHOD: During the Covid‐19 pandemic, 25 interviews were conducted with managers, nurses and care assistants from 21 care homes across Ireland. All participants provided written informed consent. Themes emerging from thematic analysis (Braun & Clarke, 2006) conceptualised understanding of how care home staff managed responsive behaviours during the COVID‐19 pandemic. Ethics approval was obtained from Lancaster University Faculty of Health and Medicine Research Ethics Committee (FHMREC20099). RESULT: Residents with dementia were perceived to be more depressed during the COVID‐19 pandemic due to the absence of family visits. However, care home staff reported that psychotropic drugs were not used more frequently for behaviour management than before the pandemic and that a person‐centred care approach was taken which involved supporting residents to participate in activities in smaller groups. Maintaining adequate staffing levels was challenging due to recruitment of nurses and care assistants from private care homes to acute public hospitals during the pandemic. Moreover, psychiatry and mental health support were difficult to access in rural regions of Ireland during COVID‐19 restrictions. Another emerging theme demonstrated that care assistants rarely contributed to equitable decision‐making, posing a barrier to implementing non‐pharmacological strategies to manage responsive behaviours. CONCLUSION: This study recommends that care homes should be prioritised in public health planning for Covid‐19, particularly to ensure optimal staffing levels and access to mental health support. In addition, care assistants should be provided with opportunities to contribute to decision‐making including case conferences. These recommendations will inform development of Department of Health policy and dementia care guidelines to facilitate implementation of non‐pharmacological strategies to manage responsive behaviours in dementia. | Alzheimers Dement | 2022 | | CORD-19 |
| 2869 | P5-135: D-dimer as a predictor severity and mortality in hospitalized COVID-19 patients at Saiful Anwar General Hospital Malang | Respirology | 2021 | | CORD-19 |
| 2870 | P5-127: Clinical characteristics of SARS-CoV-2 infected patients and mutant viral strains in rural area of Japan | Respirology | 2021 | | CORD-19 |
| 2871 | Prenatal cannabis use increased during the pandemic Pregnant women have reported using cannabis to relieve stress and anxiety, and during the COVID‐19 pandemic, the stress and prenatal cannabis use increased, according to a recent research letter published in the Journal of the American Medical Association. | N/A | 2021 | | CORD-19 |
| 2872 | P5-28: Correlation of serum interleukin-6 level and COVID-19 severity on hospital admission and survival | Respirology | 2021 | | CORD-19 |
| 2873 | P1-94: The challenges of patients that with home using long-term oxygen therapy under coronavirus pandemic | Respirology | 2021 | | CORD-19 |
| 2874 | P5-143: Post-corona virus disease 2019 pneumothorax | Respirology | 2021 | | CORD-19 |
| 2875 | Pandemic times: Perception of online cognitive stimulation groups in in older adults with cognitive complaints BACKGROUND: Cognitive reserve is a factor that can modify the clinical expression of different degenerative diseases (Stern, 2012). Some studies have shown that the older who engage in mental activities have a better overall functioning (Aguirre et al., 2013). The Institute of Neurosciences of the Favaloro Foundation offers 6 hours weekly cognitive stimulation groups to patients with cognitive complaints. In Argentina, due to lock down to decrease SARS‐COV 2 infection, the cognitive stimulation groups began to be offered online. The aim of this study is to analyze how our patients perceive the impact of the isolation after 9 months of online cognitive stimulation workshops. METHOD: 85 patients with mild executive‐attentional impairments, between 47 and 85 years old, answer a satisfaction questionnaire after attending 9 months to an online cognitive stimulation group. In these groups, patients connected twice a week through the virtual platform Google Meet. After this time, the patients were asked to answer a self‐administered questionnaire, prepared ad hoc. The satisfaction questionnaire consisted of a series of questions about the perceived changes in cognitive performance, emphasizing how they helped to cope with isolation. The study is a descriptive statistical analysis. RESULT: 72.9% of the participants reported being satisfied with online cognitive stimulation, with 77.6% believing that it was highly effective. 85.9% indicated that the isolation became more bearable thanks to the assistance. Regarding the perception of performance, 36.5% reported that their performance is better than before, while 33% register stability in their cognitive ability. CONCLUSION: the patients perceived that online cognitive stimulation allowed positive changes in cognitive performance, making isolation more bearable. In this way, we can conclude that the isolation forced us to develop new strategies and activities of rehabilitation that are likely to continue to be used in the future. | Alzheimers Dement | 2021 | | CORD-19 |
| 2876 | P5-106: Japanese, multicenter, phase II trial of combination therapy with favipiravir and methylprednisolone for COVID-19 patients with non-critical respiratory failure: the J-critical trial | Respirology | 2021 | | CORD-19 |
| 2877 | P5-92: Respiratory viruses during COVID-19 pandemic in Okinawa, Japan | Respirology | 2021 | | CORD-19 |
| 2878 | Dementia grief reconceptualized: Systemic review of psychotherapeutic approaches for BPSD and NPS during COVID-19 BACKGROUND: The biopsychosocial effects of COVID‐19 experienced by people ages 65 and greater are unprecedented. The gravity of losses will not be realized for decades. Physical, personal, economic and social constraints remain in place, generating feelings of stress and anger. Even graver of a situation is a subset of this population ‐ people who have been diagnosed with dementia and those who are more vulnerable to stress effects on the aging brain ‐ where mental health ramifications of stress are magnified. Traumatic experiences hold the possibility of reactivating previous losses that have not been fully integrated into the gut‐brain axis. At the same time, traumatic events present possibilities in releasing emancipating power when losses are modulated by access to grief‐based psychotherapies. With access to psychotherapy remaining severely limited for the most vulnerable among us, the vastness of mental health disparities remains undocumented. METHODS: Critically review psychological intervention studies investigating the biopsychosocial effects of COVID‐19 among people with dementia and assess the evidence for incorporation of grief‐based psychotherapy and presence of strengths‐based language. A systematic review of Web of Science databases was carried out by using keywords dementia and COVID‐19, employing Boolean operating word AND, with search results limited to 2020‐2021. RESULTS: From a total of 229 initial search results, 156 did not meet study criteria and were omitted. Of the 73 studies that met criteria, six thematic therapeutic approaches emerged: neuroscience, management of BPSD, pharmacological, lifestyle, social work, and technological interventions. Secondarily, studies were assigned to one of three categories on viewing COVID‐19 as an event that is: limiting or constraining, growth opportunity, or something else. CONCLUSION: Current evidence suggests that the biopsychosocial effects of COVID‐19 and dementia present a complex, dynamic and evolving relationship. Prolonged and sustained exposure to stress and trauma develops a deepening cognitive divide, where people transition from mild cognitive impairment to meeting diagnostic criteria of dementia. These times demand increasing access to grief‐informed psychological services, such as Active Capabilities Therapy, in an attempt to diminish the gut‐brain axis harms of BPSD and NPS as experienced by the individual. | Alzheimers Dement | 2022 | | CORD-19 |
| 2879 | Neuroticism is the best predictor of lower emotional resilience during the COVID‒19-related confinement periods BACKGROUND: The COVID‐19 pandemic and the associated distancing measures dramatically affect psychoaffective health, and this is accentuated in older adults who are more vulnerable to the situation. In this study, we are interested in the predictors of emotional resilience in healthy older adults, and also on how the repetition of confinement periods could influence this resilience and its predictors. METHOD: 102 cognitively unimpaired older adults from the Age‐Well cohort were included. They all completed the Depression Anxiety Stress Scales (DASS‐42) during each period of national confinement (April and November 2020), used here as a measure of emotional resilience (lower scores indicating greater resilience). Baseline measures from the Age‐Well study, all acquired before the pandemic, were used as predictors, including demographics (age, sex, education), personality (Big Five Inventory), psychological (anxiety [STAI‐B], depression [GDS]), lifestyle (Lifetime of experience questionnaire), global cognitive functioning (Mattis‐DRS) and neuroimaging data (hippocampal volume, brain perfusion, amyloid burden). We ran stepwise regressions to predict emotional resilience during the first confinement. Then, we used paired t‐test to assess the evolution of emotional resilience between the two confinements. Finally, we replicated the stepwise regressions to predict changes in resilience over time ('second‐minus‐first' confinement). RESULT: Neuroticism was the only significant predictor of the DASS‐42 score during the first confinement (β=.48; p<.001; Figure‐1), lower neuroticism being associated with better resilience. We found the DASS‐42 score to increase significantly from the first to the second confinement, indicating decreased emotional resilience over time. Moreover, higher neuroticism (β=.53; p<.001) and higher agreeableness (β=.20; p=.03) were associated with higher DASS‐42 increase over time (Figure‐2). CONCLUSION: Our study suggests that lower neuroticism is the main predictor of greater emotional resilience to the COVID‐19‐related confinement. Importantly, the repetition of the confinement situation is associated with a decrease in emotional resilience in older adults, especially if they are prone to experience distress (neuroticism) or have a particularly social personality (agreeableness). Overall, these results underline the increasing need, as the crisis persists, for a psychoaffective support of older adult. | Alzheimers Dement | 2021 | | CORD-19 |
| 2880 | P5-40: An autopsy case of COVID-19 with disseminated mucormycosis | Respirology | 2021 | | CORD-19 |
| 2881 | EXERT: Impact of COVID-19 on retention and intervention delivery of a large multisite exercise trial in adults with MCI BACKGROUND: EXERT, a multisite 18‐month RCT, is testing the effects of aerobic exercise vs. stretching on cognition and AD biomarkers in sedentary adults with MCI. In the first 12 months, participant exercise 2x/week under the supervision of YMCA trainers, and 2x/week on their own. In months 13‐18, participants continue to exercise 4x/week but without supervision. Here we describe the impact of the COVID‐19 pandemic on delivery of this support‐intensive intervention that involved many challenges but also opportunities for innovation. METHOD: In February 2020, EXERT met the recruitment goal with 296 enrolled. In March 2020 when COVID‐19 incidence rates began to climb in the US, study assessments and per‐protocol intervention delivery were paused. During the pause, all YMCAs were closed, and the majority of study‐certified YMCA trainers were furloughed. RESULT: At the time of the pause (March 23), 153 participants were in the supervised phase of the study, and 65 participants were in the unsupervised phase. To keep participants engaged and encourage adherence to the intervention, sites initiated weekly calls with active participants to provide support, address barriers to exercise and collect self‐report adherence data. By September, 7 of 14 sites resumed study activities. Weekly call completion rates during the pause exceeded 85%, and participants reported completing a mean of 3.3 40‐minute exercise sessions per week. On these calls, participants frequently expressed gratitude for the regular contact. By February 2021, all sites resumed activities despite COVID infection rates that have continued to climb across the US. In response, supervised exercise for the majority of participants was transitioned from in‐person to web‐conferencing. Even with this change that can be challenging for MCI, supervised session adherence rates are 72% for the aerobic group and 79% for the stretching group. Retention has remained high at 87%. CONCLUSION: The COVID‐19 pandemic presented unprecedented challenges, but it also provided unique opportunities to adapt intervention delivery so that a community‐based exercise trial could continue – even during a debilitating global health crisis. EXERT’s adaptations may ultimately impact resilience of the intervention to even the most challenging of circumstances that older adults with MCI will face now and in the future. | Alzheimers Dement | 2021 | | CORD-19 |
| 2882 | P5-123: The clinical features and outcomes of discharged SARS-CoV-2 patients: A prospective cohort study | Respirology | 2021 | | CORD-19 |
| 2883 | P1-8: Impact on inhalation adherence of asthma and COPD patients during the COVID-19 pandemic | Respirology | 2021 | | CORD-19 |
| 2884 | Epidemics, Convergence and Common Prosperity: Evidence from China This article investigates the impact of previous epidemics on rural development and convergence, and identifies the impact's mechanism based on convergence tests. Using a balanced panel of 31 provinces, the empirical results from 2002 to 2019 show that epidemics decelerated convergence in rural per capita income. The mechanism analysis shows that the accelerated divergence in wages and the decelerated convergence in business income were the major drivers, which also led to decelerated convergence in rural per capita consumption. Although epidemics have not threatened rural food consumption and the Engel coefficient of rural households, these two indicators of basic living needs have failed to achieve convergence across regions. The overall impact of an epidemic on convergence in rural–urban income disparity has also been insignificant, indicating that epidemics have affected rural and urban development simultaneously. Finally, COVID‐19 is likely to decelerate convergence in rural income, rural consumption, and urban income. | N/A | 2021 | | CORD-19 |
| 2885 | P5-62: Evaluation of lung cell populations in severe COVID-19 pneumonia | Respirology | 2021 | | CORD-19 |
| 2886 | COVID-19 and vaccination programme in one residential home BACKGROUND: Approximately 410 000 people live in care homes (CH) or residential settings in the UK, with the majority of this population being above the age of 85, making this group fall in the category of higher risk of more severe COVID‐19 symptoms and death. CH have been disproportionately affected by COVID‐19, people living and working in these settings have a higher risk of exposure to infection and higher risk of severe disease and mortality. CH residents and staff were prioritised for the vaccination programme in the UK due to increased risk of outbreaks, morbidity and mortality. METHOD: One Residential home reported a COVID‐19 outbreak following the vaccination programme. Most staff vaccinated between 16‐18 December 2020, and most residents vaccinated on 30/12/2020. Residents were on isolation from 22/12/2020 prior to vaccination. The first positive COVID‐19 case was on 27(th) December. Staff and residents were scored according to the World Health Organisation (WHO) Ordinal Scale for Clinical Improvement (OSCI), table 1. RESULT: Of staff vaccinated, 20,83% (n=5) tested positive for COVID‐19. Nine staff members (27.28%) didn't have the vaccine, with 7 of these (77.78%) developing more limiting symptoms (OSCI score 2), compared to 8.33% (n=2) of those who had the vaccine. With 100% of residents vaccinated, 21 residents (65,63%) developed COVID‐19 symptoms, and 31.25% (n=10) developing more limiting COVID‐19 symptoms or death. Nineteen residents have a diagnosis of dementia and 63.16% (n=12) developed COVID‐19 symptoms and 50% (n=6) of those with dementia died, whilst those without dementia did not have any deaths reported. CONCLUSION: Although this reflects the experience of a single CH, it is of relevance in suggesting substantial protection for staff who have been vaccinated, even though there was only 11 days between vaccination and the start of the outbreak. The experience in this CH starkly emphasizes the poor outcomes of COVID‐19 for residents, especially those with dementia, and unfortunately suggests that there are no benefits from vaccination as a secondary prevention approach once an outbreak has started. Ongoing evaluation will be important to optimize the delivery of the vaccination programme in CH settings, and to optimize staff take up of the vaccine. | Alzheimers Dement | 2021 | | CORD-19 |
| 2887 | COVID-19 pandemic: Quantifying the effects of the first lockdown on behavioral and cognitive measures using TASIC BACKGROUND: Following the rapid spread of the COVID‐19 virus throughout Quebec, the TRIAD cohort, a longitudinal observational study, evaluated the effects of COVID‐19 on it’s aging and vulnerable population and their caregivers. This study aims at investigating the behavioural and psychological effects of COVID‐19 and social isolation on the aging population. The TRIAD Assessment of Social Isolation and Cognition (TASIC) was developed to assess these effects on participants of observational trials. METHOD: Pre‐pandemic data including, demographical information, Clinical Dementia Rating (CDR), Mini‐Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Montreal Cognitive Assessment (MoCA) and a Social Support Questionnaire, were collected during in‐person visits and take‐home questionnaires. Following the onset of COVID‐19, TASIC was created to include additional COVID‐19 specific scales developed by Dr. Rosa‐Neto and Dr. King that include Knowledge of COVID‐19 scale, the Montreal Assessment of Stress related to COVID‐19 (MASC), as well as the Impact of Events Scale (IESR), the Peritraumatic Distress Inventory (PDI), the Peritraumatic Dissociative Experiences Questionnaire (PDEQ) for COVID‐19. Assessments were conducted via telephone interviews with TRIAD participants (n=292) and their informants (n=243) by eight trained research assistants from April through June 2020. All participants enrolled in previous TRIAD studies, deemed eligible through detailed screening criteria were contacted. RESULT: As a result of this study, and previous work done by the cohort, a culmination of information is available, with 90% of TRIAD participants having completed the COVID‐19 study also having plasma collected. 80% of participants from the COVID‐19 study have PET imaging using [(18)F]AZD4694 and [18F]MK6240 and MRI sequencing. CONCLUSION: The COVID‐19 study conducted by TRIAD provides a unique opportunity to understand the effects of a global pandemic on our aging population as well as caregiver burden. This data, in conjunction with other measures available in the cohort, can make important strides in finding ways to help, and better understand those most impacted by the crisis. | Alzheimers Dement | 2021 | | CORD-19 |
| 2888 | Predictors of generalized anxiety during the COVID-19 pandemic in older African Americans in Detroit BACKGROUND: The COVID‐19 pandemic is a health emergency that has forced a change in the daily life of individuals across all nations, races and socioeconomic groups for over a year. Such a crisis has required social isolation, the closing of businesses, schools and many recreational activities. This abrupt change has had negative effects on mental health, especially in the most vulnerable populations. METHOD: For this study, 164 community‐dwelling older African Americans (mean age = 75.6, range = 65‐94) were recruited from the Wayne State Institute of Gerontology Healthier Black Elders Center and general Detroit area. Responses were gathered over the phone between July 28, 2020 to January 14, 2021. Generalized anxiety was measured by the GAD‐7. Responses to COVID‐19 were measured by: positive emotions (eg., gratitude, happiness), negative emotion (eg., anger, fear), unmet needs (eg., food, medical care), and personal issues (eg., economic problems, reduced privacy). RESULT: Of the participants, 12 reported having COVID‐19, with 48% reporting a close family member having the virus, 26% had a death in the family and 67% endorse feelings of isolation. Average anxiety on the GAD‐7 was 6.2 (SD = 5.4, range = 0‐21). Of the 163 participants that completed the scale, 46% reported no anxiety, 28% reported mild anxiety, 17% reported moderate anxiety, and 9 % reported severe anxiety. In a stepwise regression, the following factors were found to predict GAD scores: negative emotions (51% explained variance), positive emotions (3% explained variance) and daily stressors brought on by COVID‐19 (1% explained variance). Further analyses were completed to evaluate additional models to assess the interrelationships between predictors and significant COVID‐related milestones. CONCLUSION: This current study among older African Americans living in an urban area highlights daily‐life risk factors for anxiety during the time of COVID‐19. Negative emotions as primary predictors are factors which can be specifically addressed with current psychosocial services. More research is needed in order to fully understand the scope and correlates of anxiety predictors during these challenging times. | Alzheimers Dement | 2021 | | CORD-19 |
| 2889 | The WW-FINGERS-SARS-CoV-2 initiative: Impact of the COVID-19 pandemic on brain health and prevention strategies BACKGROUND: Older adults have higher risk of cognitive impairment and dementia, and they also represent the group most severely affected by the SARS‐CoV‐2 (COVID‐19) pandemic in terms of higher morbidity and mortality. The World‐Wide FINGERS (WW‐FINGERS) global network of multidomain trials for dementia risk reduction and prevention (Kivipelto et al., 2020) provides a unique framework to explore how the pandemic has affected factors related to mental and physical health of populations at increased risk of dementia, while accounting also for country‐specific strategies to contain the spread of the infection. METHODS: The WW‐FINGERS‐SARS‐CoV2 survey has been developed to explore direct and indirect effects of the pandemic in midlife and older age. The questions aim to measure changes in lifestyle factors (e.g., diet, physical activity), management of chronic noncommunicable diseases (e.g., diabetes, hypertension), as well as psychosocial factors ‐ including depressive symptoms, sleep disorders, social isolation ‐ that are relevant to cognition and are expected to be affected by the pandemic. The survey measures also established and possible epidemiologic risk factors for severe COVID‐19. To facilitate distribution is different settings, both a pen‐and‐paper and a digital version of the survey have been developed in several languages. The digital version is supported through REDCap (Research Electronic Data Capture), a secure web‐based software that is being also used for harmonized data collection. RESULTS: Over 25 countries are taking part in the survey. Local adaptations and piloting are being done to optimize implementation in both clinical‐based and population‐based settings. Participants are in the at‐risk spectrum for dementia: from cognitively normal persons to individuals with pre‐dementia cognitive symptoms. An updated report of the survey status will be presented. CONCLUSION: the survey is a joint global action of the WW‐FINGERS network which can inform better care of older adults in the context of a pandemic. The survey is also a valuable tool for pre‐screening of participants for prevention trials, and results can inform adaptions to ensure successful recruitment and adherence in forthcoming multidomain trials for dementia prevention in older adults. | Alzheimers Dement | 2021 | | CORD-19 |
| 2890 | P5-46: Myocardial injury association with severity of disease in hospitalized COVID-19 patients | Respirology | 2021 | | CORD-19 |
| 2891 | Strategies for activity maintenance in patient and family care and clinical trial adherence of GNA social plan in context of COVID-19 health emergency BACKGROUND: The current pandemic COVID‐19 caused by SARS‐CoV2 has become a public health challenge, causing difficulty in patient care and follow up of people with cognitive impairment due to Alzheimer's disease. This situation motivated changes and adjustments to the Group of Neurosciences of Antioquia’s (GNA) Social Plan to guarantee effective continuity in patient care, family follow‐up, community interventions and adherence to the Alzheimer’s Prevention Initiative (API) Colombia clinical trial. This was an opportunity to innovate, create, reinvent and expand forms of care and intervention during confinement and pandemic to promote access through virtual media and the well‐being of beneficiaries. METHODS: The Social Plan program involves free access to basic care supplies for patients, home‐visits, support groups, cognitive stimulation groups and virtual community outreach activities like workshops for caregivers/interested public, Alzheimer's Day Commemoration “Cuidarme – Cuidarte” event (with available recorded resources), symposiums for caregivers, and informative meetings with participants of the API Colombia clinical trial. RESULTS: In the period of mandatory preventive confinement, 30 families obtained diapers, 23 families received prescription drugs not provided by health maintenance organizations (HMO) and 48 families received groceries. A total of 32 home‐visits were made: 7 in rural areas and 25 in urban areas. At the end of the mandatory preventive confinement, outpatient medical consults were resumed, no participants withdrew from the trial during this period. Thirty‐six people with MCI or dementia participated in virtual cognitive stimulation activities. Caregiver remote workshops held in the first semester of 2020 had a total attendance of 80 people, and events held in the second semester, such as the Commemoration of Alzheimer's Day and the Symposium for Caregivers, had a total attendance of 1,665 people and 1,000 people respectively. CONCLUSION: GNA’s Social Plan and the amended which includes strategies of social support, knowledge and patient/caregiver empowerment strengthened the interaction between the community and GNA and likely favorably influenced adherence and retention in the API Colombia clinical trial in the face of challenges from the global pandemic. | Alzheimers Dement | 2022 | | CORD-19 |
| 2892 | P5-90: Association of persistent and delayed symptoms with pneumonia in COVID-19 | Respirology | 2021 | | CORD-19 |
| 2893 | P5-138: Correlation between brixia score and RTPCR-SARS-CoV-2 result of pediatric patients with suspected or confirmed COVID-19 infection seen at Chong Hua Hospital, Cebu City from March 2020 to February 2021 | Respirology | 2021 | | CORD-19 |
| 2894 | O8-5: Prevalence of acute myocardial injury among COVID-19 patients in Persahabatan Hospital, Jakarta | Respirology | 2021 | | CORD-19 |
| 2895 | Greater COVID-19 impact for underrepresented racial and ethnic minority groups: A survey study on the Wisconsin Alzheimer's Disease Research Center participants BACKGROUND: The COVID‐19 pandemic has posed substantial impact on people’s life and wellbeing, especially for the aging population who are at greater risk. This study compared the difference in the impact between older adults from underrepresented racial/ethnic groups (URGs) versus non‐URGs. METHOD: The National Alzheimer’s Coordinating Center COVID‐19 Impact Survey was self‐reported by 221 participants aged 49‐99 years from the Wisconsin Alzheimer’s Disease Research Center clinical core between August and December, 2020. 43 participants who reported “Black or African American” or “American Indian or Alaska Native” in primary or secondary race or reported “Yes” to Hispanic” ethnicity were classified as URGs. The remaining 178 participants who reported only “White” or “Asian” in the primary and secondary races and “No” to “Hispanic” ethnicity were classified as non‐URGs. The survey inquired on (1) COVID‐19 symptoms, testing, diagnosis, and hospitalization; (2) worrying, social isolation, and disruption on everyday life associated with the pandemic; (3) related cognitive, psychiatric, and behavioral changes; and (4) change of willingness in research participation. Group differences on survey responses were tested using Fisher’s exact test, non‐parametric Kruskal‐Wallis test, and binary or ordinal logistic regressions. RESULT: No significant group difference was found in sex, age, and clinical diagnosis. However, URG participants had lower education and higher Clinical Dementia Rating (CDR) scores (Table 1). URGs were approximately doubled non‐URGs in the percentages of experiencing COVID‐19 symptoms, having a positive diagnosis, and reporting “very much” or “extremely” worrying about getting COVID‐19 and changing willingness to participate in clinical research. Controlling for sex, age, education, and CDR score, URGs were more likely to be tested for COVID‐19 (Odds Ratio = 2.37), have significantly reduced income (OR=4.74), experience change in memory or thinking (OR=2.97), and report a greater total number of psychiatric or behavioral changes (OR=2.04). However, URGs felt less isolated from family or friends (OR=0.55). CONCLUSION: URGs had greater medical, psychological, and economical consequences than non‐URGs, which implied racial/ethnic disparities associated with the pandemic. Future research is needed to identify inequities in the social determinants and understand their association with disparities, which would help inform policies and strategies to achieve health equity. | Alzheimers Dement | 2021 | | CORD-19 |
| 2896 | In Covid-19 pandemic, quarantine measures affect daily living activities in normal individuals, but do not change the cognitive state BACKGROUND: The coronavirus COVID‐19 pandemic is the defining global health crisis of our time. Due to the measures taken to prevent the disease and especially the curfew, the social life of people has been severely affected. It is a matter of curiosity how the cognitive state is affected during this period. METHOD: BEYNEX computerized cognitive training (CCT) has been used in android and ios environments as a smartphone and tablet application in July 2020. In this application, the scores obtained from the gamified cognitive exercises presented on the internet are presented in 8 different cognitive parameters in graphics (Memory, Visual Perception, Speed, Problem‐solving, Flexibility, Attention, Language Skills, Arithmetic). All exercises designed within the parameters used by clinicians and are completely unique. Every 2 weeks, users are asked questions that evaluate themselves and their daily life activities. The data of the user, who scores between 1 and 10 for each question, is also stored graphically. RESULT: The BEYNEX/Turkey data used in this study belong to the last four months of 2020 when quarantine measures are gradually increased. Data of an average of 250 people aged 20 to 85 were analyzed in a total of 4 months between September / December 2021. When the monthly data of the users were compared in the 4‐month period with quarantine, there was no statistical difference in 8 different cognitive parameters (Figure 1) (Table 1). However, there were important statistical differences in their responses to the questions they evaluated themselves (Figure 2) (Table 2). Less time spent on hobbies, reading, shopping, and friend conversations, while much more time on sleep and social media (Table 3). Interestingly, users rated their memory and emotional states with a high score. CONCLUSION: With internet applications, societal analyzes give results in a noticeably short time with a very low cost. Contrary to popular belief, large crises affect individual lifestyle more than cognitive parameters. It is obvious that cognitive impairment will occur if the measures involve much longer time frames. | Alzheimers Dement | 2021 | | CORD-19 |
| 2897 | P5-74: Serial changes in clinical characteristics of COVID-19 infected patients | Respirology | 2021 | | CORD-19 |
| 2898 | P5-112: The relationship of chest X-ray in COVID-19 patients towards disease severity at Arifin Achmad Regional General Hospital, Riau Province | Respirology | 2021 | | CORD-19 |
| 2899 | P5-24: Severity and clinical outcome of SARS-CoV-2 infected patients following COVID vaccination-An observational study in Bangladesh | Respirology | 2021 | | CORD-19 |
| 2900 | Higher ACE2 expression in the brains of individuals with Alzheimer's disease BACKGROUND: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a major cause of death, particularly in the elderly. The geriatric population in which cognitive decline due to Alzheimer’s disease (AD) is frequent is disproportionately affected by the pandemic. In addition, central nervous system (CNS) manifestations have been reported in a significant subset of SARS‐CoV‐2 infected patients. METHOD: Since the principal entry receptor utilized by SARS‐COV‐2 is Angiotensin‐Converting Enzyme 2 (ACE2), we examined whether ACE2 protein and mRNA levels were altered postmortem in parietal cortex samples from two different AD cohorts, totalling 142 cases. RESULTS: Both immunoblot and RT‐qPCR analysis revealed higher concentrations of ACE2 protein and mRNA in persons with a neuropathological diagnosis of AD, compared to age‐matched controls. Brain levels of ACE2 were inversely correlated with antemortem cognitive scores. We found that ACE2 protein was highly enriched in microvessels of mice compared to brain parenchyma, but not in humans. Detachment of ACE2 from brain cell membranes was strongly associated with pericytes loss. No significant change of ACE2 protein was detected in the parietal cortex from the 3xTg‐AD mouse model of AD neuropathology. CONCLUSION: Our data suggest that cognitive impairment is associated with higher levels of ACE2 in the brain, which might contribute the higher risk of CNS SARS‐CoV‐2 infection in cognitively impaired individuals and AD patients. | Alzheimers Dement | 2022 | | CORD-19 |
