| Title | Venue | Year | Impact | Source |
| 2501 | Extrinsic Compression of Inflatable Penile Prosthesis Secondary to Prone Positioning for COVID-19 Pneumonia: A Case Series of Two Patients Introduction Complications of extrinsic compression on an inflatable penile prosthesis (IPP) due to prone positioning for COVID-19 pneumonia have not been described. Patients with an IPP present a unique challenge for managing compression injuries secondary to proning due to the dependent position of the penis and ability of the device to restrict blood flow to the distal penis when externally compressed for long periods of time. We present two patients with previous IPP placement who experienced glans and penile ischemia secondary to extrinsic compression of the penis from proning, who were monitored conservatively and avoided urgent explantation. Objective To describe two patients with IPPs who were intubated and proned for COVID-19 pneumonia who experienced IPP-related complications due to pressure injury, one of whom survived for follow-up. Methods Two male patients, ages 68 and 74 years, who developed penile injury following proning for COVID-19 pneumonia. The first patient presented with skin breakdown of the ventral aspect of the penis and scrotum without exposed implant. The second patient presented with a pale and dusky glans. Results The first patient was managed by scrotal elevation with bacitracin application to the wound twice daily. There was no surgical intervention or debridement of the penile and scrotal wounds. The patient was then followed on an outpatient basis without need for explantation at 4-months from initial consultation (Figure 1). He underwent a CT of the abdomen and pelvis as well as a CT Urogram as an outpatient that confirmed appropriate positioning of all components of the device without evidence of underlying infection. On exam, the penile prosthesis was well-positioned and cycled normally, with a freely mobile pump within the scrotum. The second patient expired during hospitalization from COVID-19 respiratory failure, but was monitored for six days without glans necrosis (Figure 2) once external pressure was removed. Conclusions Patients with IPPs who require prone positioning are a unique population that are at risk for extrinsic compression injury of the penis. In contrast to ischemia related to instrinsic compression, such as with the sliding technique, which results in glans necrosis and necessitates urgent explantation, conservative treatment and serial examination in the setting of external compression from prone intubation was a viable and safe option to immediate explantation in these patients. Prevention, in the form of proper padding and minimization of external compression, remains paramount as we obtain more long term data from this unique patient population. Disclosure No | J Sex Med | 2022 | | CORD-19 |
| 2502 | Virtual Intracavernosal Injection Training During the COVID Pandemic Introduction Erectile dysfunction (ED) is a common side effect of prostate cancer treatment, and can cause considerable distress for the patient and partner. Therefore, it is beneficial to identify and implement interventions to help manage ED as early as possible. Intracavernosal injection therapy (ICI) is an option to treat ED but requires training patients to self-inject medication into the corpus of the penis. Due to the COVID-19 pandemic, the Sexual Rehabilitation Clinic (SRC) was closed resulting in delays in ICI training. In order to address this problem, we transitioned the training strategy from in-person visits to virtual care. Objective This study describes our experience delivering ICI training virtually during the pandemic. Methods Patients agreed to participate in the virtual training via web-based teleconference software and were assigned to read educational material and view an instructional video prior to the appointment, as per our in-patient clinic process. The virtual training sessions included review of anatomy, mechanisms of action of the medication(s), side effects, and management thereof. Preparation of the syringe and the process of injecting a prosthetic penis were demonstrated. Principles of medication titration were reviewed. Remaining questions were answered and virtual or telephone follow-up was scheduled. Results Within 7 weeks of closure, we pivoted to offer our Sexual Health Clinic virtually. From July 2020 to May 2021, 50 patients had virtual appointments booked for ICI training, 49 of whom completed virtual ICI training (1 pt could not fill his prescription and didn't rebook). We learned early on that having proper visual props (medication vial, syringe, penis model and instruction booklet) and good camera positioning to clearly see the medication preparation and injection technique were instrumental for successful training. Virtual health appointments lasted 35 to 45 minutes compared to 60 minutes in-person, reducing training times by 15 to 25 minutes per patient. At the end of each session, participants verbally affirmed that the sessions were clear and easy to follow and that learning ICI from the comfort of home, without the stress of travel, and the cost of parking were beneficial aspects of virtual health. Another benefit from the clinic perspective was the elimination of clinic preparation pre-visit and post-visit cleaning. A post-session survey answered by 21 patients demonstrated that 80.9% were satisfied with the virtual teaching and that 52.3% were very confident or extremely confident about using ICI injections. 76% of respondents had used ICI within the last month at the time of the survey. Conclusions The COVID-19 pandemic was an impetus for us to change our standard of practice for ICI training. Despite our concern that patients would not gain enough confidence if not seen in person, this was not the case. Benefits of virtual health included shorter clinic times, removal of geographic and financial barriers, and ability to provide timely training for ICI injections. Based on our positive experience delivering ICI training virtually, we plan to offer the option of in-person or virtual appointments when COVID-19 restrictions are lifted. Disclosure No | J Sex Med | 2022 | | CORD-19 |
| 2503 | Development of a rapid neutralizing antibody test for SARS-CoV-2 and its application for neutralizing antibody screening and vaccinated serum testing Background : Since the outbreak of coronavirus disease (COVID-19), the high infection rate and mutation frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent, have contributed to the ongoing global pandemic. Vaccination has become the most effective means of controlling COVID-19. Traditional neutralizing tests of sera are complex and labor-intensive, therefore, a rapid test for detecting neutralizing antibodies and antibody status post-immunization is needed. Methods : Based on the fact that antibodies exhibit neutralizing activity by blocking the binding of the S protein receptor-binding domain (S-RBD) to ACE2, we developed a rapid neutralizing antibody test, ACE2-Block-ELISA. To evaluate the sensitivity and specificity, we used 54 positive and 84 negative serum samples. We also tested the neutralizing activities of monoclonal antibodies (mAbs) and 214 sera samples from healthy individuals immunized with the inactivated SARS-CoV-2 vaccine. Results : The sensitivity and specificity of the ACE2-Block ELISA were 96.3% and 100%, respectively. For neutralizing mAb screening, ch-2C5 was selected for its ability to block the ACE2–S-RBD interaction. A plaque assay confirmed that ch-2C5 neutralized SARS-CoV-2, with NT50 values of 4.19, 10.63, and 1.074 μg/mL against the SARS-CoV-2 original strain, and the Beta and Delta variants, respectively. For the immunized sera samples, the neutralizing positive rate dropped from 82.14% to 32.16% within 4 months post-vaccination. Conclusions : This study developed and validated an ACE2-Block-ELISA to test the neutralizing activities of antibodies. As a rapid, inexpensive and easy-to-perform method, this ACE2-Block-ELISA has potential applications in rapid neutralizing mAb screening and SARS-CoV-2 vaccine evaluation. | N/A | 2022 | | CORD-19 |
| 2504 | Les universités et les facultés de médecine françaises, fer de lance du projet d'Europe de la Santé | N/A | 2022 | | CORD-19 |
| 2505 | User Characteristics of Unique Men's Health Website Introduction Covid-19 has helped drive all forms of medicine away from traditional brick and mortar medical interactions. Given the availability of online services to obtain treatments for ED, we developed a website to facilitate patient education, triage and men's health appointment scheduling. Objective We sought to assess characteristics of men who utilized a novel website to treat their ED. Methods We report on 50 patients who ultimately booked and attended appointments (video or in person) for erectile dysfunction. Patients found our website through our institution's main informational ED pages or through youtube links from our men's health video playlist library. Patients create an institutional account and are then asked a series of MD created questions designed to streamline patient triage and complete the majority of chart documentation ahead of the appointment. Patients are then sent videos relevant to their condition and future appointment options. Results 2300 users investigated the ED portion of the website with 1.8% of patients ultimately following through with an appointment. 13% of patients who explored the ED portion of the site created a user account that allows a questionnaire to be taken. 90% of men who began the ED questionnaire completed with a mean time of 11 minutes. 52% of men offered an appointment based on their responses completed the patient scheduling form. 71% of traffic was on mobile devices with 29% on desktop/tablet. Site use by time of day is shown in figure 1. Mean age of patients was 53. 92% of patients had ED that occurred > 6 months. Mean SHIM score was 8.2 (IQR 4-12). 80% of participants had both desire and opportunity for sexual activity, 20% did not meet both criteria and thus SHIM scores were less valid for these men. Of the users 28% had never tried pde5s, 32% had partial success with pde5s, 24% could not tolerate or afford pde5s and 42% had unsatisfactory results with pde5s. PDE5 naïve patients were seen by an internal medicine MD specializing in men's health, 10 were seen by surgeons as they requested IPPs and the rest were seen by a combination of men's health APPS and urology attendings for second line treatments and penile doppler. Interestingly, 66% of men were interested in undergoing penile doppler to better understand the etiology of their ED. Hypertension (40%) and diabetes (22%) were the most common medical comorbidities. 36% of the cohort had a strong family history of cardiac disease. Conclusions Men with ED can be effectively triaged through a website application. Most men with pde5 refractory ED wish to pursue penile doppler. The majority of patients seen had watched educational video material ahead of time, facilitating a more sophisticated and streamlined patient interaction. Disclosure No | J Sex Med | 2022 | | CORD-19 |
| 2506 | Analysis of farmers' environmental sustainability behavior: the use of norm activation theory (a sample from Iran) Human activities are the most effective and significant cause of environmental changes, some of which are destructive and others are beneficial. One of the most effective steps to protect the environment is to assess farmers’ behavior in achieving the goals of environmental sustainability. This study aimed to analyze the environmental sustainability behavior of farmers using the norm activation theory (NAT) in a questionnaire-based survey. The statistical population comprised wheat farmers in Kermanshah province, Iran (N = 126,900). The sample size was determined to be 382 farmers by Krejcie and Morgan’s table. The validity of the questionnaire was verified by experts and its reliability was confirmed by a pilot test and calculating Cronbach’s alpha. Five variables of perceived behavior control, perceived self-efficacy, ascription of responsibility, denial of responsibility, and awareness of consequences had significant effects on personal norms. The variable of personal norms had a significant effect on farmers’ sustainable behavior. By and large, it can be concluded that NAT can adequately account for the environmental sustainability of farmers. | N/A | 2022 | | CORD-19 |
| 2507 | Seminar-Highlights im Juni | Freie Zahnarzt | 2022 | | CORD-19 |
| 2508 | P24 Cefiderocol activity against a multidrug-resistant (MDR) strain of Pseudomonas aeruginosa: a case report BACKGROUND: MDR Gram-negative bacteria such as Pseudomonas aeruginosa represent the highest priority for addressing global antibiotic resistance. Moreover, selecting an appropriate empirical antibiotic treatment for MDR strains is a challenge. Cefiderocol, a novel siderophore cephalosporin, has demonstrated activity against Gram-negative strains resistant to other available antibiotics. PATIENT CASE: A 58-year-old female was admitted on to the ICU with type 1 respiratory failure as a consequence of COVID-19 pneumonitis. During the course of her ICU admission she developed persistent bilateral empyema and pneumothorax which did not resolve despite the use of pleural drains. The empyema samples grew P. aeruginosa. TREATMENT COURSE: The patient was treated with commonly used antibiotics for P. aeruginosa, including piperacillin/tazobactam, meropenem, ceftolozane/tazobactam and ciprofloxacin. However, repeated testing of empyema fluid and respiratory secretions identified an increasingly drug-resistant P. aeruginosa strain. Following left thoracotomy and pleural decortication, cefiderocol was approved for compassionate use and the patient was treated for 14 days. The patient experienced good resolution of clinical symptoms and C-reactive protein levels and was discharged to the ward after 105 days in the ICU. The patient was briefly readmitted to the ICU with worsening type 2 respiratory failure 2 weeks later. Ceftolozane/tazobactam and colistin treatment were recommenced as a bridging measure until cefiderocol became available in the hospital. Notably, the P. aeruginosa isolated remained susceptible to cefiderocol following the first course of treatment. Cefiderocol therapy (2 g t.i.d.) was recommenced for 14 days of ward based treatment. The patient demonstrated clinical and radiographic resolution of her infection and was eventually discharged home. CONCLUSIONS: This patient case describes a heavily pretreated female with a MDR P. aeruginosa strain successfully managed with cefiderocol and source control. Cefiderocol was prescribed for compassionate use for treatment of MDR P. aeruginosa. Treatment was well tolerated and led to good resolution of clinical symptoms. Cefiderocol may help address the global issue of MDR P. aeruginosa. | JAC Antimicrob Resist | 2022 | | CORD-19 |
| 2509 | P14 Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study BACKGROUND: A minority of patients presenting to hospital with COVID-19 have bacterial coinfection. Procalcitonin testing may help identify patients for whom antibiotics should be prescribed or withheld. The PEACH study describes the use of procalcitonin in English and Welsh hospitals during the first wave of the COVID-19 pandemic to help diagnose bacterial infections and guide antibiotic treatment. There is a lack of clear evidence to support its use in lung infections, which means in some hospitals, clinicians have used the procalcitonin test to guide antibiotic decisions in COVID-19, whilst in other hospitals, they have not. Our study is analysing data from hospitals that did and did not use procalcitonin testing during the first wave of the COVID-19 pandemic. It will determine whether and how procalcitonin testing should be used in the NHS in future waves of COVID-19 to protect patients from antibiotic overuse. METHODS: To assess whether the use of PCT testing, to guide antibiotic prescribing, safely reduced antibiotic use among patients who were hospitalized with COVID-19 during the first wave of the pandemic, we are answering this question through three different, and complimentary, work streams (WS), each with discrete work packages (WP): (i) Work Stream 1: utilization of PCT testing to guide antibiotic prescribing during the first wave of COVID-19 pandemic; (ii) Work Stream 2: patient-level impact of PCT testing on antibiotic exposure and clinical outcome (main work stream currently in analysis); and (iii) Work Stream 3: health economics analysis of PCT testing to guide antibiotics in COVID-19. RESULTS: Our first publication from Work Stream 1 (Antibiotics 2021, 10: 516) used a web-based survey to gather data from antimicrobial leads about the use of procalcitonin testing. Responses were received from 148/151 (98%) eligible hospitals. During the first wave of the COVID-19 pandemic, there was widespread introduction and expansion of PCT use in NHS hospitals. The number of hospitals using PCT in emergency/acute admissions rose from 17 (11%) to 74/146 (50.7%) and use in ICU increased from 70 (47.6%) to 124/147 (84.4%). This increase happened predominantly in March and April 2020, preceding NICE guidance. Approximately half of hospitals used PCT as a single test to guide decisions to discontinue antibiotics and half used repeated measurements. There was marked variation in the thresholds used for empirical antibiotic cessation and guidance about interpretation of values. CONCLUSIONS: Procalcitonin testing has been widely adopted in the NHS during the COVID-19 pandemic in an unevidenced, heterogeneous way and in conflict with relevant NICE guidance. Further research is needed urgently that assesses the impact of this change on antibiotic prescribing and patient safety. Work Stream 2 is ongoing, and results will be published once available. | JAC Antimicrob Resist | 2022 | | CORD-19 |
| 2510 | O03 The impact of COVID-19 infection prevention and control measures on transmission of hospital-acquired infections and antimicrobial resistance in Africa BACKGROUND: Patients who develop serious illness due to COVID-19 are more likely to have bacterial coinfections, for which WHO recommends treatment with antibiotics. As a result, many countries are observing a change in antimicrobial stewardship (AMS), in addition to changes in infection prevention and control (IPC) practices such as the use of personal protective equipment, on COVID-19 wards. Few data on COVID-19 and its impact on nosocomial infections and antimicrobial resistance (AMR) are available from low and middle-income countries (LMICs). As these countries often have high rates of AMR, it is vital to report the effects of COVID-19 on AMS so as to inform clinical practice and IPC guidelines. This study aims to compare prevalence of AMR in COVID-19 wards with general non-COVID-19 hospital wards. METHODS: This pilot hospital-based study is being conducted in two sites in both Sudan and Zambia. IPC and AMS guidelines for COVID-19 and non-COVID-19 wards were identified for each institution. This study is comparing bacterial isolates and AMR patterns of nosocomial associated infections acquired on COVID-19 and non-COVID-19 wards were compared, using microbiological and sequencing methods. A total of 200 patients have been recruited: 100 per country, 50 COVID-19 patients and 50 non-COVID-19 patients. AMR transmission patterns are being identified using Oxford Nanopore Technologies sequencing for phylogenetic analysis. RESULTS: The study began recruiting in May 2021 and completed recruitment of patients in October 2021. The majority of microbiological laboratory work will be completed within Q3 2021, with analysis of the results and sequencing completed in Q4 2021. A half-way point summary analysis of the data suggests differences in patient profiles, both between COVID-19 and non-COVID-19 wards at both sites, as well as differences between the two countries. Preliminary analysis also suggests a significant difference between the prevalence of MDR infections in Gram-negatives seen between COVID-19 (53% in Sudan and 83% in Zambia) and non-COVID-19 (14% Sudan, 33% Zambia) (t-test, P=0.0032 Sudan, P=0.0455 Zambia) ward patients in both countries (see Figure 1). CONCLUSIONS: The study is providing evidence to inform policy on IPC and AMS measures to be implemented on COVID-19 wards. In addition, the outcomes of the study will be used to create a pragmatic sequencing pipeline for potential AMR outbreaks suitable for use in LMICs clinical settings. | JAC Antimicrob Resist | 2022 | | CORD-19 |
| 2511 | Online activism and redress for institutional child abuse: function and rhetoric in survivor advocacy group tweets In Australia, survivor advocacy groups have been closely engaged with the emergence and development of policy and redress responses to institutional child abuse. Their activities and influence in this respect have been under-researched. This study focuses on the use of Twitter, a tool increasingly employed by activist groups in their lobbying repertoires. Using content and thematic analysis, tweets of 15 non-survivor led advocacy groups, and one survivor-led organisation—Care Leavers Australasia Network (CLAN)—referring to ‘redress’ were analysed for rhetorical content (via Aristotle’s traditional framework of ethos, pathos, and logos) and communication purposes using three broad functional areas defined by Lovejoy and Saxton (2012). In keeping with Lovejoy and Saxton’s (2012) framework, the results found that for both non-survivor led advocacy groups and CLAN the primary function of their use of Twitter was to convey information to audiences. However, the integrated use of the rhetoric framework with the function framework revealed markedly different lobbying styles between the non-survivor led advocacy groups and CLAN with the latter pursuing a more confrontational and direct style of lobbying in communications. CLAN also overwhelmingly pursued emotion-focussed rhetoric in lobbying communications. | N/A | 2022 | | CORD-19 |
| 2512 | Social representations, media and iconography: A semiodiscursive analysis of Facebook posts related to the COVID-19 pandemic The aim of this study was to explore the COVID-19 pandemic social representation in the early stages of its development. Following a free association task and a categorical analysis, a corpus of COVID-19-related editorial illustrations from articles posted by leading French newspapers was collected. Iconographic analysis of editorial illustrations revealed 12 iconic patterns that seemed typical of the pandemic iconography. Findings suggest that articles eliciting the greatest engagement (i.e. reactions, comments, and shares) are those that use a stable iconography so that the topic can easily be identified by most Facebook users. Therefore, these images could play an important role in the objectification process development of the COVID-19 social representation. Future studies should therefore explore the impact of the relationship between the news media and their audiences on the visual representation of highly topical issues, in the light of the objectification process of social representation theory. | Eur J Commun | 2022 | | CORD-19 |
| 2513 | How the COVID-19 Pandemic Impacted the Perception of Climate Change in the UK The COVID-19 pandemic erupted during the climate change (CC) crisis, forcing individuals to adapt abruptly to a new scenario, and triggering changes in everyone’s lifestyles. Based on a sample of the UK population (N = 1013), this paper investigates how the COVID-19 pandemic invited/forced individuals to reflect upon a more sustainable way of life (which might be enhanced by the use of digital technologies for daily activities) and to (re)consider the anthropogenic impact on the environment. The results show that older individuals tend to be less sceptic around the human impact on CC. Other control variables such as income, gender and employment status have a limited impact on this attitude towards CC. Secondly, the findings indicate a clear separation between those with a minimal level of education, who support the natural origin of CC, while individuals with a higher level of education believe that CC is caused by human actions. Finally, on average, younger and more educated individuals tend to associate the COVID-19 pandemic with an opportunity to promote an eco-friendly world and to adopt an eco-sustainable approach. | Am Behav Sci | 2022 | | CORD-19 |
| 2514 | Fiscal Consolidation and Automatic Stabilization: New Results We derive a novel measure of household income stabilization and analyze how reforms of tax-benefit systems in the period 2007–2014 have affected the workings of automatic stabilizers in the EU-27. Our results reveal that the heterogeneity in automatic stabilizers across EU countries has become slightly smaller over the period under consideration. With a few exceptions, automatic stabilizers could operate freely in the early phase of the financial and economic crisis, but were constrained in several EU countries by subsequent fiscal consolidation measures. A comparison of our estimates of automatic stabilizers inherent in tax-benefit systems with macro measures such as changes in cyclically adjusted budget balances reveals that micro-based estimates provide more precise information about the degree of household income stabilization. | N/A | 2022 | | CORD-19 |
| 2515 | The effects of gender and personality of robot assistants on customers' acceptance of their service The Covid-19 pandemic has stimulated the use of social robots in front-office services. However, some initial applications yielded disappointing results, as managers were unaware of the level of development of the robots’ artificial intelligence systems. This study proposes to adapt the Almere model to estimate the technological acceptance of service robots, which express their gender and personality, whilst assisting consumers. A 2 × 2 (two genders vs. two personalities) between-subjects experiment was conducted with 219 participants. Model estimation with Structural Equation Modelling confirmed seven out of eight hypotheses, and all four scenarios were estimated with Ordinary Least Squares, showing that robot gender and personality affected their technological acceptance. | N/A | 2022 | | CORD-19 |
| 2516 | Students' Development of a Logarithm Function in Python Using Taylor Expansions: a Teaching Design Case Study We present here the lessons learned by iteratively designing a tutorial for first-year university students using computer programming to work with mathematical models. Alternating between design and implementation, we used video-taped task interviews and classroom observations to ensure that the design promoted student understanding. The final version of the tutorial we present here has students make their own logarithm function from scratch, using Taylor polynomials. To ensure that the resulting function is accurate and reasonably fast, the students had to understand and apply concepts both from computing and from mathematics. We identify three categories of such concepts and identify three design features that students attended to when demonstrating such understanding. Additionally, we describe four important take-aways from a teaching design point of view that resulted from this iterative design process. | N/A | 2022 | | CORD-19 |
| 2517 | Older People's Use of Digital Technology During the COVID-19 Pandemic Objectives: The COVID-19 pandemic is having a major impact on the lives of everyone, but in particular on the health and well-being of older people. It has also disrupted the way that individuals access services and interact with one another, and physical distancing and “Stay at Home” orders have seen digital interaction become a necessity. While these restrictions have highlighted the importance of technology in everyday life, little is known about how older adults have responded to this change. Methods: Two surveys, one in 2019 and another in 2020 collected data on a combined total of 1923 older adults aged 65 years and older in Canada. These looked at how older adults think about and use technology, with the 2020 survey additionally questioning how COVID-19 has impacted their use and attitudes towards technology. Results: While older adults feel more isolated in 2020, many feel positive about the benefits of technology and have increased technology use during the pandemic to support their health, wellness, and communication needs. Discussion: The results highlight the potential of technology for supporting older adults in various aspects of healthy aging. While these results point to the opportunities afforded by technology, challenges remain, such as how social and economic factors influence technology uptake. | Bull Sci Technol Soc | 2022 | | CORD-19 |
| 2518 | Resilience strategies to recover from the cascading ripple effect in a copper supply chain through project management As the supply chains are growing and becoming more interdependent, the vulnerability and the chances of supply chain failure also increases. The supply chain industry is severely affected due to the COVID-19 outbreak and industry practitioners are focusing on minimizing the ripple effect of the disruption made to the economy. Considering the unprecedented situation, the research is motivated to analyse the ripple effect in a multi-echelon supply chain and investigate the performance at various nodes to understand the capability of the supply chain to withstand the disruptions at different levels. Using discrete event simulation, this study analyses the ripple effect in the copper industry by an agent-based simulation software anyLogistix, considering various key performance indexes (KPIs) to gauge the magnitude. From the results of the simulation, it is evident that the lack of safety stocks and multi-sourcing of copper facilitate as major causes for the disruptions. The simulation helps to understand the disruption levels and make the supply chain more resilient and robust for any future disruption. Further, the study proposes resilient project management solutions to recover from the cascading ripple effect in the copper supply chain. The scientific contribution of the research is to provide supply chain managers with simulation techniques to understand the ripple effect on the copper supply chain. It helps the stakeholders to understand the importance of project management tools to reduce the cascading ripple effect in a copper supply chain. Further, the findings of this study will support contemporary managers, supply chain allies, project managers, and stakeholders to formulate strategies for recovering from the supply chain disruptions caused due to natural disasters, pandemics such as COVID-19. | N/A | 2022 | | CORD-19 |
| 2519 | Challenges to agile project management during COVID-19 pandemic: an emerging economy perspective Globally, COVID-19 pandemic has affected more than 214 countries across the world, creating uncertainty and affecting every institution and individual. The organisations recognise the need of agile projects that may offer several benefits including faster deployments, adaptability and best fit alignment to fulfill the customer needs. Implementing agile projects is the key to survive in the post pandemic situation, but emerging economies have limited scope for implementation. The present study determines the critical factors that restricts implementation of agile projects in emerging economies. The critical factors are identified from literature and validated by experts. The validated critical factors are further assessed to identify the cause-and-effect relationship using Fuzzy Decision-Making Trial and Laboratory (F-DEMATEL) method. The results of the study posit ‘Skepticism towards the new way of working’ is the most significant causal factor affecting other factors. This study is an attempt to help project managers to consider the significant factors for agile project implementation in post pandemic situation. The project managers may be benefitted from this study by considering these factors to manage challenges for agile project implementation in emerging economies. This study contributes to assess the influencing and the influenced challenging factors for agile project implementation. | N/A | 2022 | | CORD-19 |
| 2520 | The organizational side of a disruption mitigation process: exploring a case study during the COVID-19 pandemic This paper deals with the mitigation process of the COVID-19 pandemic. Scholars propose and discuss several mitigation strategies to face the COVID-19 disruptions, mainly focusing on technology and supply chain redesign related aspects. Less attention has been paid to the organizational aspects of the mitigation process. We address this gap through an in-depth analysis of the reactive organizational practices implemented by an Italian company during the COVID-19 pandemic. We further compare these practices with those proposed in the disruption management literature to identify common traits and differences. The results show that the overall management of a pandemic’s mitigation process does not significantly differ from that of conventional disruptions, since both contexts require the same basic organizational practices. However, some peculiarities on how these practices should be implemented in a pandemic setting do emerge, such as the implementation of a cyclic rather than linear problem-solving process, the adoption of a learning-by-doing approach, the need of a risk-taker mindset and the importance of creativity and improvisation. Besides complementing the literature, these findings allow to provide indications to managers on how to organize and coordinate the activities during the mitigation process, as well as on what capabilities and competencies should be leveraged to face the pandemic’s disruptions. | N/A | 2022 | | CORD-19 |
| 2521 | Investigating the role of stakeholder engagement for more resilient vaccine supply chains during COVID-19 The complexity of the supply chains and the uncertainties in the processes cause business to become more vulnerable in the face of disruptions. Pandemic situations such as COVID-19 cause sudden disruptions in supply chains, causing processes to be disrupted. Especially in multi-stakeholder supply chains, the importance of stakeholder communication, motivation, and regulations i.e. comes to the forefront in order to ensure the resilience of supply chains. As learned with the COVID-19 pandemic, vaccine supply chains are also one of the multi-stakeholder supply chains and are extremely vulnerable to disruptions. In COVID-19 times, the importance of vaccine supply chain management and the resilience in vaccine supply chains increased. To have more resilient vaccine supply chains, stakeholder engagement is an essential issue. Therefore, the Graph Theory Matrix Approach has been used to determine factors of stakeholder engagement in multi-stakeholder vaccine supply chains and to specify the relationships between the factors of project and stakeholder engagement in vaccine supply chains to increase resilience in disruption times. The aim of the study is to identify the factors of project and stakeholder engagement that are necessary to ensure the resilience of multi-stakeholder vaccine supply chains and not be affected by disruptions such as COVID-19 as it is today. As a result of the study, innovativeness of stakeholders is the most important factor of stakeholder engagement in vaccine supply chains. | N/A | 2022 | | CORD-19 |
| 2522 | Covid-19 Disaster relief projects management: an exploratory study of critical success factors The COVID-19 pandemic has caused unprecedented socio-economic devastation. With widespread displacement of population/ migrants, considerable destruction of property, increase in mortality, morbidity, and poverty, infectious disease outbreaks and epidemics have become global threats requiring a collective response. Project Management is, however, a relatively less explored discipline in the Third Sector, particularly in the domain of humanitarian assistance or exploratory projects. Via a systematic literature review and experts' interviews, this paper explores the essence of humanitarian projects in terms of the challenges encountered and the factors that facilitate or hinder project success during crises like Covid-19. Additionally, the general application of project management in international assistance projects is analysed to determine how project management can contribute to keeping the project orientation humane during a crisis. The analysis reveals that applying project management tools and techniques are beneficial to achieve success in humanitarian assistance projects. However, capturing, codifying, and disseminating the knowledge generated in the process and placing the end-users at the centre of the project life cycle is a prerequisite. While the latter can seem obvious, the findings demonstrate that the inadequate inclusion of beneficiaries is one of the main reasons that prevent positive project outcomes leading to unsustainable outcomes. The key finding of this paper is that the lack of human-centred approaches in project management for humanitarian assistance and development projects is the main reason such projects fail to achieve desired outcomes. | N/A | 2022 | | CORD-19 |
| 2523 | Gut zu wissen-Aktuelles fachübergreifend rund um den Diabetes | N/A | 2022 | | CORD-19 |
| 2524 | Für Herz und Nieren von Diabetespatienten lässt sich was machen | N/A | 2022 | | CORD-19 |
| 2525 | SMS-Präventionsprojekt wappnet Kinder gegen Adipositas und Diabetes | N/A | 2022 | | CORD-19 |
| 2526 | Inzidenzzunahme des Typ-1-Diabetes bei Kindern und Jugendlichen in der Pandemie | N/A | 2022 | | CORD-19 |
| 2527 | Petrography and geochemistry of beach sediments along the central coast of Cameroon: constraints on paleoweathering, provenance and tectonic setting The paleoweathering, provenance, and tectonic setting of the source region were determined with compositional and geochemical analyses of sediments obtained from the beach locations of Yoyo, Mouanko, and Mbiako along the central coast of Cameroon. The beach sediments are medium to coarse-grained and are brown to light brown. Their mineralogy is dominated by quartz and clay minerals with a medium amount of feldspars, rutile, goethite, hematite, and calcite. Moreover, their petrography is made up of quartz and feldspars, with low proportions of augite, apatite, biotite, and zircon. The sediments are classified as sublitharenite, and they are mostly made up of felsic rocks derived from the adjacent Neoproterozoic magmatic and gneissic basement rocks. Weathering indices such as the chemical index of alteration (CIA) and plagioclase index of alteration (PIA) indicated that in this study, the source area’s weathering intensity was moderate. The index of chemical variability (ICV) indicates a low maturity. The geochemistry data revealed passive and rift settings for the beach areas, which are congruent with the local geology. | N/A | 2022 | | CORD-19 |
| 2528 | Ed's welcome | N/A | 2022 | | CORD-19 |
| 2529 | Dental students face wellbeing crisis | N/A | 2022 | | CORD-19 |
| 2530 | The key to delivering successful online presentations | N/A | 2022 | | CORD-19 |
| 2531 | High Entropy Alloy and Bulk Metallic Glass Coatings | N/A | 2022 | | CORD-19 |
| 2532 | Wesleyan Foundation supports 15 dentistry students with £65,000 Scholarship funding | N/A | 2022 | | CORD-19 |
| 2533 | BDA Benevolent Fund is here to support YOU | N/A | 2022 | | CORD-19 |
| 2534 | Akzeptanz und Nutzung von E-Mental-Health-Angeboten unter Studierenden: Sekundäranalyse eines Experiments OBJECTIVE: Despite the effectiveness of various e‑mental health interventions, relatively low usage rates have been identified, even among digital natives like university students. The aim of this study is therefore to examine the relationship between the general acceptance, the specific interest and actual registration rates for selected targeted e‑mental health programs. METHODS: We conducted a secondary analysis of a survey study with n = 451 students (89% distance-learning students) that was embedded in an online experiment targeting information effects on the acceptance of e‑mental health services, including the investigation of usage intentions and interest in relation to objective data in terms of registrations regarding selected e‑mental health services for stress prevention and health promotion. RESULTS: A hierarchical regression analysis showed the stress level, perceived similarity with information sources and attitudes as determinants of usage intentions (R(2) = 0.49). Less than one-third of the sample (31%) reported current interest in participating in one specific e‑mental health service. Furthermore, the intention–behavior gap at the follow-up assessment (n/N in %) was lower for the program for employees (85% registered) than for the program for students (69% registered; 77% overall). CONCLUSION: More than three quarters of interested students have registered for a program, which calls for providing simple, direct access options. Future studies should examine the determinants of use and adherence to e‑mental health services depending on the acceptance in various subgroups of students in order to develop tailored acceptance-facilitating measures. | N/A | 2022 | | CORD-19 |
| 2535 | Free flu jabs for dentists axed by NHS England | N/A | 2022 | | CORD-19 |
| 2536 | Risks of Development of COVID-19 among Patients with Inflammatory Bowel Disease: A Comparative Assessment of Risk Factors for Incident Infection BACKGROUND: Patients with inflammatory bowel disease (IBD) may be at risk for development of COVID-19 infection due to innate immune dysfunction and/or immunosuppressive medication use. METHODS: In a prospective cohort of adult IBD patients, we captured data on clinical risk factors and IBD medication utilization. The outcome of interest was development of patient-reported laboratory confirmed COVID-19. We calculated incidence rate and performed bivariate analyses to describe the effects of risk factors (age, immunosuppression use, obesity, race) on development of COVID-19. We utilized logistic regression models to determine the independent risks associated with each factor. RESULTS: A total of 3953 patients with IBD were followed for a mean duration of 212 days (SD 157). A total of 103 individuals developed COVID-19 during follow up (2.6%, rate of 45 per 1,000 person-years). Severity of infection was generally mild. Clinical characteristics were similar among those who developed COVID-19 as compared to not. African American race was associated with incident COVID-19 infection (OR 3.37, 95% CI 1.18-9.59).Immunosuppression use was not associated with development of COVID-19 (OR 1.19, 95% CI 0.72-1.75), nor was age (OR 1.00, 95% CI 0.99-1.02), nor obesity (OR 1.01, 95% CI 0.61-1.66). CONCLUSIONS: Immunosuppression use did not increase the risk of development of COVID-19. Therapeutic management of IBD should not be altered to prevent a risk of developing COVID-19. | Crohns Colitis 360 | 2022 | | CORD-19 |
| 2537 | In vitro models and ex vivo systems used in inflammatory bowel disease Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn’s disease are types of inflammatory bowel disease. Over many decades, the disease has been a topic of study, with experts still trying to figure out its cause and pathology. Researchers have established many in vivo animal models, in vitro cell lines, and ex vivo systems to understand its cause ultimately and adequately identify a therapy. However, in vivo animal models cannot be regarded as good models for studying IBD since they cannot completely simulate the disease. Furthermore, because species differences are a crucial subject of concern, in vitro cell lines and ex vivo systems can be employed to recreate the condition properly. In vitro models serve as the starting point for biological and medical research. Ex vivo and in vitro models for replicating gut physiology have been developed. This review aims to present a clear understanding of several in vitro and ex vivo models of IBD and provide insights into their benefits and limits and their value in understanding intestinal physiology. | N/A | 2022 | | CORD-19 |
| 2538 | The Force of Law? Transparency of Scientific Advice in Times of Covid-19 Freedom of Information Acts (FOIA) are valuable legal tools to access information held by public authorities but during the first wave of the Covid-19 pandemic time frames to reply to requests were de jure or de facto suspended in many countries. However, the lack of effective legal tools to achieve transparency was not automatically paired with governmental secrecy. This research paper analyses which are the factors that prompted some governments to move from secrecy to transparency while the essential legal tool to achieve disclosure of information was not available. It focuses on the role of ‘ecologies of transparency’, a concept developed by Seth Kreimer to describe how FOIA needs to be understood as functioning within a collection of factors and actors. Yet, can transparency ecologies still force disclosure of information when FOIA is suspended? Research focuses on a comparative case study about transparency of scientific committees advising governments on Covid-19 in the UK and in Spain. In both countries, members and minutes were initially secret, but the British government published information before being forced by FOIA, while the Spanish executive only released partial information when FOIA was reactivated. The paper argues that information disclosure processes can be understood as supply and demand models. On the demand side, it highlights the role of adversarial press, scientific community, whistle-blowers, the opposition and critics within the governing party as decisive factors within the transparency ecology. On the supply side, it focuses on legitimation needs from the government to explain different outcomes. | N/A | 2022 | | CORD-19 |
| 2539 | We Have Always Been Cyborgs. Digital Data, Gene Technologies and an Ethics of Transhumanism: Stefan Lorenz Sorgner 2022 (Bristol University Press) ISBN: 978-1529219203. 240 pp | Nanoethics | 2022 | | CORD-19 |
| 2540 | Hautkrebsprävention in Deutschland: „Gute Kommunikation ist das A und O": Interview mit Prof. Dr. Eckhard W. Breitbart, Vorsitzender der Arbeitsgemeinschaft Dermatologische Prävention (ADP), Buxtehude | N/A | 2022 | | CORD-19 |
| 2541 | Trust and digital privacy: willingness to disclose personal information to banking chatbot services This study explored digital privacy concerns in the use of chatbots as a digital banking service. Three dimensions of trust were tested in relation to user self-disclosure in order to better understand the consumer-chatbot experience in banking. The methodology selected for this research study followed a conclusive, pre-experimental, two-group one-shot case study research design which made use of a non-probability snowballing sampling technique. Privacy concerns were found to have a significantly negative relationship with user self-disclosure in both treatment groups. Respondents exposed to their preferred banking brand experienced lower user self-disclosure and brand trust than those exposed to a fictitious banking brand within the South African context. It is recommended that companies using chatbots focus on easing privacy concerns and build foundations of trust. The gains that chatbots have made in the form of increased productivity and quality of customer service rely on relationships with users who need to disclose personal information. Through this study, we concluded that, despite its power to influence decision-making, the power of a brand is not enough for consumers to considerably increase self-disclosure. Rather, a bridge of trust (through education, communication and product development) is needed that encompasses all three elements of trust, which are brand trust, cognitive trust and emotional trust. Limited research exists on the relationship between financial services marketing and chatbot adoption. Thus, this study addressed a theoretical gap, by adding brand trust to existing studies on cognitive and emotional trust regarding user self-disclosure. | N/A | 2022 | | CORD-19 |
| 2542 | Energizing collaborative industry-academia learning: a present case and future visions In Industry-Academia Collaborations (IAC) both academic, scientific research results and industrial practitioner findings and experiences are produced. Both types of knowledge should be gathered, codified, and disseminated efficiently and effectively. This paper investigates a recent (2014–2017) large-scale IAC R&D&I program case (Need for Speed, N4S) from a learning perspective. It was one of the programs in the Finnish SHOK (Strategic Centres of Science, Technology, and Innovation) system. The theoretical bases are in innovation management, knowledge management, and higher education (university) pedagogy. In the future, IAC projects should be more and more commonplace since major innovations are hardly ever done in isolation, not even by the largest companies. Both intra-organizational and inter-organizational learning networks are increasingly critical success factors. Collaborative learning capabilities will thus be required more often from all the participating parties. Efficient and effective knowledge creation and sharing are underpinning future core competencies. In this paper, we present and evaluate a collaboratively created and publicly shared digital knowledge repository called “Treasure Chest” produced during our case program. The starting point was a jointly created Strategic Research and Innovation Agenda (SRIA), which defined the main research themes and listed motivating research questions to begin with—i.e., intended learning outcomes (ILO). During the 4-year program, our collaborative industry-academia (I-A) learning process produced a range of theoretical and empirical results, which were iteratively collected and packaged into the Treasure Chest repository. Outstandingly, it contained, in addition to traditional research documents, narratives of the industrial learning experiences and more than 100 actionable knowledge items. In conclusion, our vision of the future is that such transparently shared, ambitious, and versatile outcome goals with a continuous integrative collection of the results are keys to effective networked I-A collaboration and learning. In that way, the N4S largely avoided the general problem of often conflicting motives between industrial firms seeking answers and applied solutions to their immediate practical problems and academic researchers aiming at more generalizable knowledge creation and high-quality scientific publications. | N/A | 2022 | | CORD-19 |
| 2543 | Big 5, Little Choice? Lehren aus der Pandemie für die Regional- und Binnennachfrage nach Safaridestinationen Auf das südliche Afrika verteilte sich vor der Pandemie circa 2 % des weltweiten internationalen Reiseaufkommens. Davon erreichten fast die Hälfte dieser jährlichen Ankünfte Südafrika. Während der Pandemie hat sich gezeigt, dass gerade die Zugpferde des internationalen Tourismusmarketing der Region, die Safarilodges und Naturerlebnisanbieter, ohne Ankünfte aus Übersee nicht zu bewirtschaften sind. Als Alternative für diesen Nachfrageeinbruch wird einer Steigerung der Regional- und Binnennachfrage kaum Potenzial zugestanden. Dieser Standpunkt soll hier bestritten werden, ohne dabei jedoch vom Alleinstellungsmerkmal des Safaritourismus abzurücken. Die Empfehlung zielt stattdessen auf eine Erweiterung des Angebotsspektrums ab. Dabei werden 3 Absichten verfolgt: Erstens, den Mangel an der Binnennachfrage für die klassischen Reiseangebote der Region zu ergründen, zweitens Chancen für eine Aufwertung des Afrikabildes darzulegen und drittens Potenziale für eine Produktdiversifizierung aufzuzeigen, die auch eine wachsende Regional- und Binnennachfrage in den Blick nimmt. | N/A | 2022 | | CORD-19 |
| 2544 | Pre-service Teachers' Reflections on Attitudes Towards Teaching and Learning Mathematics with Online Platforms at School: A Case Study in the Context of a University Online Training Online learning platforms take over a new role in education, especially in times of the Covid-19 pandemic. This paper will discuss pre-service teachers’ reflections on attitudes towards online learning platforms and the respective changes due to an online training of using this digital tool in mathematics classes. The special training took place in a bachelor seminar with fourteen participants on the use of digital media in mathematics education at the University of Siegen. Based on the ‘Tripartite Model of Attitude Structure’ which defines the psychological concept of attitude, data material about the pre-service teachers’ attitudes is gathered by pre- and post-reflection-questionnaires. A qualitative content analysis led to the formation of a system of six main categories and approximately 51 descriptors for pre-service teachers’ attitudes towards online learning platforms and especially their changes due to the online training of using these platforms. The descriptors can be a basis for further research studies on this topic. | N/A | 2022 | | CORD-19 |
| 2545 | Irish secondary school science teachers' perspectives on addressing the COVID-19 crisis as socioscientific issues Development of scientific literacy is a crucial aim of science education across the globe and research suggests that this can be realized through student exploration of socioscientific issues. While the COVID-19 crisis, emergency school closures and restrictions to in-class teaching, had negative impacts on teaching and on student learning and wellbeing, it also presents an opportunity to explore authentic socioscientific issues. This research explores teachers’ perspectives on addressing the COVID-19 crisis as socioscientific issues in secondary science education. This qualitative study surveyed 266 Irish secondary school science teachers about their experiences during the COVID-19 crisis. Thematic analysis was used to identify the reasons why teachers did and did not address the COVID-19 crisis as SSI. These findings were triangulated with findings from follow-up interviews. The majority of teachers in this study addressed the COVID-19 crisis as SSI. The COVID-19 crisis was explored within the curriculum, through project work and research, and through classroom discussion. Teachers described four barriers to exploring the COVID-19 crisis with their students: The COVID-19 crisis was not part of the curriculum; The lack of F2F contact made judging students’ reactions challenging; There was already too much focus on the COVID-19 crisis in everyday life and concerns over student wellbeing while discussing the sensitive topic of the COVID-19 crisis. Teachers noted that addressing the COVID-19 crisis led to benefits to student learning, health, wellbeing and hygiene. | N/A | 2022 | | CORD-19 |
| 2546 | Mesenchymal Stem/Stromal Cells: MESENCURE: A PROFESSIONALIZED CELL THERAPY FOR ARDS REDUCED THE MORTALITY OF SEVERE COVID-19 PATIENTS BY 68% ACCORDING TO A RECENTLY CONCLUDED MULTI-CENTER, CONTROLLED PHASE II STUDY | Cytotherapy | 2022 | | CORD-19 |
| 2547 | Immunotherapy: OFF-THE-SHELF PARTIAL HLA MATCHING SARS-COV-2 ANTIGEN SPECIFIC T CELL THERAPY: A NEW POSSIBILITY FOR COVID- 19 TREATMENT | Cytotherapy | 2022 | | CORD-19 |
| 2548 | Immunotherapy: TIMING OF DONOR SELECTION ON CD45RA-MEMORY T CELLS AS ADOPTIVE CELL THERAPY FOR COVID-19 | Cytotherapy | 2022 | | CORD-19 |
| 2549 | Process Development and Manufacturing: THE IMPACT OF THE COVID-19 PANDEMIC ON THE CELL AND GENE THERAPY SUPPLY CHAIN | Cytotherapy | 2022 | | CORD-19 |
| 2550 | Mesenchymal Stem/Stromal Cells: SAFETY OF CORD TISSUE DERIVED MESENCHYMAL STROMAL CELLS IN COVID-19 RELATED ACUTE RESPIRATORY DISTRESS SYNDROME | Cytotherapy | 2022 | | CORD-19 |
