This version of BIP! Finder aims to ease the exploration of COVID-19-related literature by enabling ranking articles based on various impact metrics.
Last Update: 18 - 01 - 2023 (628506 entries)
Popularity: Citation-based measure reflecting the current impact.
Influence: Citation-based measure reflecting the total impact.
Reader Attention: The current number of Mendeley readers.
Social Media Attention: The number of recent tweets related to this article.
*More details on these impact measures can be found here.
Exceptional score (in top 0.01%).
Substantial score (in top 1%).
Average score (in bottom 99%).
Score not available.
CORD-19 dataset(1) (list of papers)
LitCovid hub(2) (list of papers)
PMC & PubMed (citations)
Mendeley (number of readers)
COVID-19-TweetIDs(3) (tweets)
| Title | Venue | Year | Impact | Source | |
|---|---|---|---|---|---|
| 2451 | Outcomes Following Lvad Implantation In Covid-19 Patients Purpose End-stage heart failure patients are at an increased risk of severe disease and complications from coronavirus disease-2019 (COVID-19). Additionally, the disease increases perioperative risks The purpose of this study was to describe the clinical course following left ventricular assist device (LVAD) implantation in patients with COVID-19. Methods A single-center, retrospective review between March 2020 and March 2021 identified 6 patients with a history of COVID-19 who subsequently underwent LVAD implantation. Baseline characteristics, clinical course, and outcomes were examined. Results Patients were male (83%), Black (67%), and implanted with a Heartmate 3 for destination therapy. The time from COVID-19 diagnosis to LVAD surgery ranged from 3 days to 6 months (median 40 days, [IQR 12-114 days]). All patients were supported with an intra-aortic balloon pump (IABP) and high-dose inotropes prior to implant. The median age was 60 years (IQR 57-61 years) and body mass index 30 kg/m2 (IQR 24-31 kg/m2). Following implantation, 5 patients (83%) had respiratory failure greater than 7 days on ventilator support, 2 (33%) required tracheostomy, and 2 (33%) were reintubated before successful extubation. Two patients (33%) required temporary right ventricular assist device (RVAD) support, 4 patients (67%) needed continuous renal replacement therapy (CRRT), and 3 patients (50%) suffered ischemic strokes: two patients on postoperative day 1, and the other on postoperative day 5. The median length of hospital stay following surgery ranged from 16 to 73 days (median 53 days, [IQR 35-67 days]). Five patients (83%) were discharged from the hospital, 2 to acute inpatient rehab, 1 to a subacute rehabilitation facility, and 2 to home. Two patients (33%) were readmitted within 30 days for gastrointestinal bleeding and neuropathic pain. There was one (17%) 30-day hospital mortality due to multisystem organ failure following a stroke and the decision to withdraw care. | J Card Fail | 2022 | CORD-19 | |
| 2452 | Cardiac And Inflammatory Biomarkers And New Or Worsening Heart Failure In High-risk Patients With COVID-19 Introduction Consequences of COVID-19 on the cardiovascular (CV) system are broad and have encompassed conditions including cardiomyopathies and acute coronary syndrome. Inciting triggers are likely multifactorial, with reported mechanisms ranging from a pro-inflammatory cytokine storm to microvascular ischemia. Elevated inflammatory markers including high sensitivity C-reactive protein (hsCRP), d-dimer, and interleukin-6 (IL-6) have been associated with adverse outcomes in COVID-19. We sought to identify the association of cardiac and inflammatory biomarkers with new or worsening HF in patients admitted with COVID-19. Methods We performed a single-centered prospective cohort study of patients who were hospitalized with COVID-19 from September 2020 through April 2021. Blood serum specimens from enrolled patients were collected upon hospital admission, weekly and upon discharge for quantification of troponin T, B-natriuretic peptide (BNP), and inflammatory biomarkers, including immune cell subtypes, cell activation markers, and plasma cytokines. New or worsening HF was defined as any new left ventricular (LV) systolic dysfunction, decrease in ejection fraction >5% or a decompensated state in those with a prior history of HF. Results Twelve of the 41 patients who were enrolled presented with new or worsening HF. Of this subgroup, 6 had new or worsening LV systolic function, 7 had concomitant myocardial injury represented by elevated troponin and there were no biopsy-confirmed cases of myocarditis. The average age of this subgroup was 65.8 years (interquartile range [IQR] 55.6-76.0) and 67% were male. All patients had at least 3 CV risk factors upon presentation and 75% had a prior diagnosis of HF (p < 0.01). Clinical profiles were otherwise similar between groups, and there were no significant differences in acute medical management. Among those with new or worsening HF, median BNP was elevated (345, IQR 184-509 vs 95, IQR 38.5-171 pg/nl, p = 0.01), as was median troponin (201, IQR 30-620 vs 16, IQR 0-56.5 ng/L, p = 0.02). Otherwise, there were no significant differences noted in baseline or follow-up biochemical markers of inflammation, including hsCRP, IL-6 and d-dimer, between patients with and without new or worsening HF. Conclusion Patients admitted with COVID-19 who experience new or worsening HF syndrome have elevated BNP and troponin levels, but similar CV risk factors compared to those who do not. Baseline measures of inflammation are not greater in those who develop HF syndrome in the setting of COVID-19. | J Card Fail | 2022 | CORD-19 | |
| 2453 | The Effects Of Coronavirus Pandemic Lockdown On Patients With Chronic Heart Failure Background the coronavirus pandemic and the resulting restrictive measures have beenassociated with social isolation and limited access to health care especially forpatients with chronic diseases. In Tunisia, the lockdown was implemented for 6 weeks, we sought by this study to evaluate the impact of the coronavirus outbreak and lockdown on patients with chronic heart failure. Patients and methods After the lockdown ended; 184 patients included in the Tunisian registry of heart failure (NATURE HF) from two centers: Medenine and Ariana, were interviewe by phone and invited to answer an 18-point questionnaire to assess the impact of the lockdown on their health state and on the management of their disease. Results In total, 274 patients were contacted and responses were available for 184 patients. Responders were mostly followed up at Medenine hospital (n=143; 77.7%); had mean age 66.87 ±13.5 years and a sex ratio 1.5. The majority of patients were treated for ischemic cardiomyopathy (55.4%) and reduced ejection fraction (51.5%). The aggravation of heart failure signs was common (32%) and 20.7 % felt their health state was poorer than before lockdown. Few patients had used telemedicine to get a medical advice or distance control (23.3%); the unique used method was the telephone call. The rate of patients who had missed their regular visits due to lockdown was 34.2%. Adherence to salt restriction was reduced in 39.7% and treatment cessation was noted in 24.5%. Difficulty obtaining heart failure medications during the lockdown was19% . One forth of patients considered that the COVID-19 pandemic had affected the management of their disease and 22.4% reported feeling in danger during the closure period. The most barrier measures used at first intention were hand washing (32.1%) and social distancing (29.9%). Conclusion The COVID19 pandemic lockdown had a negative impact on patients with chronic heart failure. During the lockdown, symptoms aggravation and medication non- adherence were common. Telemedicine was used in only 23% of cases. | J Card Fail | 2022 | CORD-19 | |
| 2454 | SMEs navigating COVID-19: The influence of social capital and dynamic capabilities on organizational resilience Building the resilience capacity of businesses is important for economic, social and community recovery during the COVID-19 pandemic, yet organizational resilience is under-examined in the marketing literature. Crises and disasters can significantly impact small and medium enterprises (SMEs), affecting their ability to mitigate, respond and recover. Social capital (SC) is a key resource that can be mobilized by SMEs to tap the resources embedded in internal and external relationships to respond to disruptions, yet the mechanism through which SC facilitates organizational resilience is not clear. Using middle-range theorizing, we propose dynamic capabilities (DC) as the key sensing, seizing and reconfiguration resources that transform SC into organizational resilience. The results from a sample of SMEs (n = 419) in Australia and New Zealand demonstrate that internal SC has a positive effect on external SC (customer-focused). Only internal SC has a direct effect on organizational resilience. DC partially and fully mediates the relationship between internal and external SC and organizational resilience respectively. Implications for theory and practice are offered. | N/A | 2022 | CORD-19 | |
| 2455 | Changes in travel behaviors and intentions during the COVID-19 pandemic and recovery period: A case study of China The COVID-19 pandemic severely hit the tourism industry in China and worldwide. Chinese government adopted extensive nonpharmaceutical interventions (NPIs) to control it. COVID-19 has been well under control since April 2020 and China entered into a unique recovering period. The aim of this study is to examine how the COVID-19 pandemic changed residents' travel behaviors and intentions and investigate the theoretical factors associated with these changes during the pandemic and the recovery period. This study used a mixed-methods approach by combining quantitative surveys (N = 1,423) and qualitative interviews (N = 34). We extended the theory of planned behavior (TPB) to include other emerging factors in the context of the COVID-19 pandemic, such as risk perception, tourist trust, and charitable attitude. Our findings show that COVID-19 changed respondents' travel preferences in different ways, for example, tend to choose natural/outdoor/uncrowded attractions over cultural/indoor/crowded attractions. Second, respondents' domestic travel behaviors and intentions were positively associated with constructs in TPB, charitable attitude to contribute to the recovery of the tourism industry, tourists' trust in domestic COVID-19 control, and awareness of destinations' promotion strategies, while domestic travel intentions were negatively associated with risk perception. Third, concerns about the international COVID-19 control and travel restrictions were the two major factors affecting residents' intentions to travel abroad. Finally, we highlighted the management implications including implementing strict preventive measures while improving the effectiveness, increasing tourists’ trust, and adopting diverse marketing and promotion strategies. | N/A | 2022 | CORD-19 | |
| 2456 | Impact de la pandémie liée au COVID-19 sur la pratique des jeux vidéo selon la personnalité et le type de passion dans une population adulte Introduction : La pandémie liée au COVID-19 a modifié les habitudes quotidiennes de la population. Dans ce contexte, certaines activités ont été favorisées, parfois même encouragées, telles que l’usage des jeux vidéo (JV). Objectif : L’objectif de cette étude était d’investiguer l’impact de la pandémie sur la pratique des JV en tenant compte du type de passion et de la personnalité. Méthode : Une méthodologie mixte a été utilisée. En sus de la quantité de pratique des JV, le Big Five Inventory a permis d’évaluer la personnalité et l’Echelle de passion de distinguer le type de passion selon le modèle dualiste. Un entretien semi-directif permettait d’évaluer l’impact des confinements sur la pratique ludique et le ressenti du joueur durant cette période. Parmi les 137 joueurs de JV (âge moyen de 30,26 ans) ayant rempli les auto-questionnaires, 10 ont participé à l’entretien semi-directif. Résultats : Quel que soit le type de passion, le temps de pratique des JV a augmenté durant les confinements (en fréquence et en temps). Une relation négative a été retrouvée entre l’Ouverture et le temps de pratique des JV la semaine avant et durant la pandémie, ainsi qu’avec la passion obsessive. Les données qualitatives ont montré que le JV est apparu comme une activité occupationnelle, source de plaisir, d’évasion par rapport émotions négatives liées à la crise sanitaire, et de soutien social. Conclusion : L’usage des JV a été évoqué par les participants comme une stratégie efficace pour faire face aux difficultés engendrées par la pandémie de COVID-19. Introduction: The pandemic linked to Covid-19 has changed the daily habits of the population. In this context, some activities have been favored, sometimes even encouraged, such as the use of video games. Objective: The objective of this study was to investigate the impact of the COVID-19 pandemic on video game use taking into account the type of passion and personality. Method: A mixed methodology was used. In addition to the amount of gaming use, the Big Five Inventory was used to assess personality and the Passion Scale to distinguish the type of passion according to the dualistic model. A semi-structured interview made assessed the impact of confinements on gaming use and the gamer’s feelings during this period. Among the 137 gamers (mean age 30.26) who completed the self-questionnaires, 10 participated in the semi-structured interview. Results: Whatever the type of passion, gaming use increased during the lockdown period (in frequency and time). A negative relationship was found between Openness and gaming use during the week before and during the pandemic, as well as with obsessive passion. Qualitative data showed that gaming use emerged as an occupational activity, source of pleasure, escape from negative emotions related to the COVID‑19 pandemic, and social support. Conclusion: The use of video games was mentioned by participants as an effective strategy to deal with the difficulties caused by the COVID-19 pandemic. | N/A | 2022 | CORD-19 | |
| 2457 | Der Wert des Reiseschutzes bemisst sich an Corona | N/A | 2022 | CORD-19 | |
| 2458 | How to survive a pandemic | Lancet Respir Med | 2022 | CORD-19 | |
| 2459 | Informa's 22nd Minsands Conference Highlights The Importance of Australia & Africa | N/A | 2022 | CORD-19 | |
| 2460 | Students' engagement across a typology of teacher feedback practices The provision of feedback is widely practised as part of formative assessment. However, studies that examine the impact of feedback are usually from the teachers’ perspective, focusing on why and how they provide feedback. Fewer studies examine feedback from the students’ perspective, especially in the way they experience, make sense of and take up their teachers’ feedback. This paper provides empirical evidence of student engagement with different patterns of teacher feedback in their written essays. Data were gathered from 45 students (from 5 different schools) through group interviews and analysis of student artefacts from three rounds of writing tasks. The findings on affective, behavioural and cognitive engagement surfaced the conditions that will contribute to students’ will and skill to act on their teachers’ feedback. The implications on both teacher and student assessment literacy are discussed. The discussion will provide professional development providers and policy makers with new perspectives of and approaches to strengthening formative assessment practices in ways that are more cognizant of students’ experience of feedback. | N/A | 2022 | CORD-19 | |
| 2461 | Durable Vitality and Magical Forms | Emerg Infect Dis | 2022 | CORD-19 | |
| 2462 | Creating supply chain resilience during and post-COVID-19 outbreak: the organizational ambidexterity perspective This study aims to investigate the significance of organizational ambidexterity (OA) in creating supply chain resilience (SCRES) during and after the COVID-19 pandemic. The methodological triangulation is applied in this study. A literature review, semi-structured online interviews and insights from open webinars serve as the sources of data. A framework, based on three pillars: validation, positioning and evaluation of business practices, is used for data analysis. The dependencies between OA activities and SCRES strategies are presented. The authors discuss their evolution during and in the post-pandemic period and outline the SCM trends in a strategic perspective. This paper investigates a pathway for closing the gap between OA theory and industry practice to create SCRES during and post-COVID-19 outbreak. This article starts the discussion on creating SCRES through OA. Future quantitative and qualitative research should explore the applicability of OA to enhance SCRES in a dynamic environment. Understanding the critical connection between exploitation and exploration practices and how OA influences SCRES provides valuable insight into the subject to supply chain managers supporting them in pursuing their roles successfully in the times of crisis. This study is focused on two concepts, OA and SCRES, of critical importance for how practitioners manage supply chains in the times of crisis. The resilience of supply chains to crises is crucial for the well-being of societies. | N/A | 2022 | CORD-19 | |
| 2463 | Protection of Foreign Investment in China: The Foreign Investment Law and the Changing Landscape China’s foreign investment law regime has experienced significant changes in recent years. A milestone came with the passing of the Foreign Investment Law (FIL) in 2019, replacing the laws and regulations that had governed foreign investment in China for four decades. This article first undertakes a political economic analysis to determine the relevance of internal and external factors contributing to the changes. It then discusses the key characteristics of the FIL and reveals how it is designed to create a liberal, stable, fair, transparent and accountable regime to promote and protect foreign investment. Although the passage of the FIL ushered in a new era of foreign investment in China, many important issues remain unresolved and further actions must be taken to ensure its smooth implementation. To support the sustained development of its foreign investment regime, China must address existing laws and regulations that are incompatible with the new regime, clarify key issues that the new law fails to address, issue clearer guidance on national security, shorten its ‘negative list’, promote opening up and enhance regulatory transparency. | N/A | 2022 | CORD-19 | |
| 2464 | Stationäre Patienten mit der Nebendiagnose Diabetes mellitus: klinische Relevanz About 3 million patients with diabetes are treated as inpatients in German hospitals every year, whereby 93% of them are not treated because of diabetes but diabetes was a secondary diagnosis. In some departments, up to 40% of patients have a secondary diagnosis of diabetes. They often have a relevant comorbidity and, compared to hospital patients without diabetes, a longer inpatient stay, develop complications significantly more often and are more frequently readmitted in the short term. This review analyses the clinical relevance of the secondary diagnosis of diabetes mellitus for hospitalized patients. | N/A | 2022 | CORD-19 | |
| 2465 | Comparison of microwave and autoclave treatment for biomedical waste disinfection As the world is facing a Covid-19 pandemic, this virus teaches a lesson about the importance of on-site disinfection. On-site disinfection/sterilization with real-time monitoring of biomedical waste generated from the medical facilities is mandatory to prevent hospital-acquired infection (HAI). In this study, the life cycle assessment of two technologies, i.e., microwave (radiation-based) and autoclave (steam-based) were performed to summarize the inside-out evaluation of both technologies in terms of efficiency, efficacy, and cost-effectiveness. The results of disinfection efficacy indicated a log 10 reduction (almost 100%) in the vegetative load of microorganisms compared to the control, showing a similar level of disinfection efficacy of both strategies. Additionally, both technologies were compared on several parameters, and it was discovered that the autoclave uses more time and resources than the microwave. The total cost of an autoclave to the government is approximately double that of a microwave, while the operational cost of an autoclave is more than double that of a microwave. The findings from this study indicate that MACS may be used as a dry technique of biomedical disinfection, and its portability, tunability, and compactness make it a suitable alternative for biomedical disinfection and sterilization. GRAPHICAL ABSTRACT: [Image: see text] | N/A | 2022 | CORD-19 | |
| 2466 | Kurzmeldungen | N/A | 2022 | CORD-19 | |
| 2467 | ÖGARI-UPDATE | N/A | 2022 | CORD-19 | |
| 2468 | Das schwere Thoraxtrauma-ein Fallbericht | N/A | 2022 | CORD-19 | |
| 2469 | Cardiac complications in patients with COVID-19: a systematic review Cardiac complications in patients with COVID-19 have been described in the literature with an important impact on outcome. The primary objective of our systematic review was to describe the kind of cardiac complications observed in COVID-19 patients and to identify potential predictors of cardiovascular events. The secondary aim was to analyze the effect of cardiac complications on outcome. We performed this systematic review according to PRISMA guidelines using several databases for studies evaluating the type of cardiac complications and risk factors in COVID-19 patients. We also calculated the risk ratio (RR) and 95% CI. A random-effects model was applied to analyze the data. The heterogeneity of the retrieved trials was evaluated through the I(2) statistic. Our systematic review included 49 studies. Acute cardiac injury was evaluated in 20 articles. Heart failure and cardiogenic shock were reported in 10 articles. Myocardial infarction was evaluated in seven of the papers retrieved. Takotsubo, myocarditis, and pericardial effusion were reported in six, twelve, and five articles, respectively. Arrhythmic complications were evaluated in thirteen studies. Right ventricular dysfunction was evaluated in six articles. We included 7 studies investigating 2115 patients in the meta-analysis. The RR was 0.20 (95% CI: 0.17 to 0.24; P < 0.00001, I(2) = 0.75). Acute cardiac injury represented the prevalent cardiac complications observed in COVID-19 patients (from 20 to 45% of the patients). Patients with acute cardiac injury seemed to be significantly older, with comorbidities, more likely to develop complications, and with higher mortality rates. Acute cardiac injury was found to be an independent risk factor for severe forms of SARS-CoV-2 infection and an independent predictor of mortality. Due to the scarce evidence, it was not possible to draw any conclusion regarding Takotsubo, myocarditis, pleural effusion, and right ventricular dysfunction in COVID-19 patients. Noteworthy, possible arrhythmic alterations (incidence rate of arrhythmia from 3 to 60%) in COVID-19 patients have to be taken into account for the possible complications and the consequent hemodynamic instabilities. Hypertension seemed to represent the most common comorbidities in COVID-19 patients (from 30 to 59.8%). The prevalence of cardiovascular disease (CVD) was high in this group of patients (up to 57%), with coronary artery disease in around 10% of the cases. In the majority of the studies retrieved, patients with CVD had a higher prevalence of severe form, ICU admission, and higher mortality rates. | N/A | 2022 | CORD-19 | |
| 2470 | Early mortality following COVID-19 infection among cancer patients who received radiotherapy: a meta-analysis INTRODUCTION: Identifying the patients at higher risk for poor outcomes after radiotherapy (RT) during coronavirus disease 19 (COVID-19) era is an unmet clinical need. METHODS: The Ovid MEDLINE, Ovid Embase, Clarivate Analytics Web of Science, PubMed and Wiley-Blackwell Cochrane Library databases were searched. Eligible studies were required to address the outcomes of cancer patients who underwent RT during the COVID-19 era. The primary outcome was early mortality, while secondary outcomes included length of hospital stay, hospital admission, intensive care unit (ICU) admission and use of mechanical ventilation. Pooled event rates were calculated, and meta-regression and ‘leave-one-out’ sensitivity analyses were performed. RESULTS: Twelve eligible studies were included out of 928. The prevalence of early mortality after COVID-19 infection was 21·0%. The prevalence of hospital admission, ICU admission and mechanical ventilation was 78·1, 15·4 and 20·0%, respectively. Meta-regression showed that older age was significantly and positively associated with early mortality (β = 0·0765 ± 0·0349, p = 0·0284), while breast cancer was negatively associated with early mortality (β = −1·2754 ± 0·6373, p = 0·0454). CONCLUSIONS: Older age adversely impacts the early mortality rate in cancer patients during COVID-19 era. The risks of interruption/delay of cancer treatment should be weighed against the risk of increased morbidity and mortality from the infection. A global registry is needed to establish international oncologic guidelines during the COVID-19 era. | J Radiother Pract | 2021 | CORD-19 | |
| 2471 | A Highly Sensitive Graphene-based Field Effect Transistor for the Detection of Myoglobin Biomedical applications adapt Nano technology-based transistors as a key component in the biosensors for diagnosing life threatening diseases like Covid-19, Acute myocardial infarction (AMI), etc. The proposed work introduces a new biosensor, based on Graphene Field Effect Transistor (GFET), which is used in the diagnosis of Myoglobin (Mb) in human blood. Graphene-based biosensors are faster, more precise, stronger, and more trustworthy. A GFET is created in this study for the detection of myoglobin biomarker at various low concentrations. Because graphene is sensitive to a variety of biomarker materials, it can be employed as a gate material. When constructed Graphene FET is applied to myoglobin antigens, it has a significant response. The detection level for myoglobin is roughly 30 fg/ml, which is quite high. The electrical behavior of the GFET-based biosensor in detecting myoglobin marker is ideal for Lab-on-Chip platforms and Cardiac Point-of-Care Diagnosis. | N/A | 2022 | CORD-19 | |
| 2472 | Thinking About Pedagogy: A Collection of Articles | N/A | 2022 | CORD-19 | |
| 2473 | Tourism sustainability during COVID-19: developing value chain resilience The aim of this study is to evaluate the perceptions of prospective tourists through parameters by which the tourism and hospitality service sector can withstand the widespread implications to the sector as a result of the current pandemic. In turn this will lead to weighing up the means for recovery. The identified parameters are then classified, categorized and linked up with supply chain drivers to obtain a holistic picture that can feed into strategic planning from which the tourism and hospitality service sector could utilize to establish a resilient supply chain. This data can provide deep insight for both theorists and practitioners to utilize. It was found that reforming six supply chain drivers, whilst at the same time developing core competencies, is the central essence of a resilient supply chain within the tourism and hospitality business sector (who are at present working hard to counterbalance the many threats and consequent risks posed due to the pandemic). | N/A | 2022 | CORD-19 | |
| 2474 | Production scheduling optimization for parallel machines subject to physical distancing due to COVID-19 pandemic This paper, for the first time, presents a production scheduling model for a production line considering physical distancing between the machines' workforces. The production environment is an unrelated parallel-machine, in which for producing each part, different machines with different production rates and the required number of workers are available. We propose a three-objective mixed-integer linear programming mathematical model that aims to maximize the manufacturer's total benefit, parts' safety stock (SS) index, and the workforce's physical distance over a finite horizon (one year) by determining the optimal scheduling of the parts on the machines. Since a large production scheduling problem belongs to the Np-Hard category of problems, a non-dominated sorting genetic algorithm, and a non-dominated ranked GA algorithm are developed to solve the presented model in two stages using the empirical data from a Canadian plastic injection mold company. In the first stage, the LP-metrics approach is utilized for validating the meta-heuristics on a reduced-size problem. In the second stage, the validated meta-heuristics are utilized to optimize the company's yearly production schedule. The results indicate both metaheuristics are performing well in determining the optimal solution. Moreover, implementing physical distancing in the company reduces the company's monthly net benefit by around 9.56% compared to the normal operational conditions (without considering physical distancing). | N/A | 2022 | CORD-19 | |
| 2475 | Role of corporate governance in quick response to Covid-19 to improve SMEs' performance: evidence from an emerging market This paper aims to evaluate the role of corporate governance on performance of the small and medium-sized enterprises by exploring the mediating role of social responsibility engagement and environmental responsibility engagement between corporate governance and firm performance in the context of an emerging market. The paper follows a quantitative approach. The study sample was composed of 495 responses covering top executives, managers, and experts. The Analysis of a moment structures (AMOS version 20) was used to analyze the small and medium-sized enterprises data in an emerging economy in Southeast Asia in the year 2021. Our findings revealed that corporate governance has a significant and positive relationship with firm performance, social responsibility engagement and environmental responsibility engagement. In addition, social responsibility engagement and environmental responsibility engagement are found to mediate the relationship between corporate governance and firm performance. To the best of our knowledge, this is the first research that explores the mediating role of social responsibility engagement and environmental responsibility engagement between corporate governance and firm performance for the small and medium-sized enterprises. This study has novel contributions by providing important insights into the effective corporate governance mechanism and how corporate governance contributes to improving firm performance towards sustainability through engaging in social and environmental responsibility. Additionally, its application to food the small and medium-sized enterprises in the current context of an emerging economy in Southeast Asia reinforces the originality of this study. This study contributions are of great interest to academics, experts, business practitioners, and policymakers. | N/A | 2022 | CORD-19 | |
| 2476 | Uncovering interrelationships between barriers to unmanned aerial vehicles in humanitarian logistics Recent disasters, such as the ongoing COVID-19 pandemic, have sparked an interest in new applications for unmanned aerial vehicles (UAVs) in humanitarian aid. Nevertheless, there are still many divisive changes that need to be made in order to implement UAVs into a country’s humanitarian sector successfully. Hence, this paper aims to analyze the various barriers hindering the implementation of UAVs in humanitarian logistics for both developed and developing nations. To accomplish this, the study is presented in three steps. First, previous literature and opinions from experts are analyzed to illuminate particular factors that hinder UAV implementation. Next, we propose an interval-valued intuitionistic fuzzy set (IVIFS) based graph theory and matrix approach (GTMA) to calculate a drone implementation hindrance index (DIHI). The GTMA method used in this paper utilizes the PERMAN algorithm to calculate the permanent function. Finally, the DIHI values are plotted and analyzed to compare the readiness of drone implementation between developed and developing economies. A sensitivity analysis is then performed to provide validity to the results obtained. The study has revealed that both types of countries must first improve their inadequate government regulations regarding humanitarian UAVs. Developing countries must also focus on enhancing the technological awareness of their population. The results of this study can be used by policymakers and practitioners to smoothly implement UAVs in their country's humanitarian sector. The general index defined in this paper can also be calculated for specific countries using the steps mentioned in the manuscript. | N/A | 2022 | CORD-19 | |
| 2477 | Managing Covid-19 pandemic and supply chain disruptions through employee attitude: A cross-country analysis based on the transtheoretical model In this paper, we examine the attitudinal changes and processes regarding Covid-19 guidelines through the lens of the Transtheoretical Model (TTM) among 932 employees in organisations within the emerging markets of China and Qatar, and the implications for the management of operations and supply chain disruptions. Exploratory and confirmatory factor analysis, and hierarchical multiple regression were conducted to validate our measures, confirm model fit, and verify the proposed hypotheses. Our findings reveal that attitude towards the guidelines differ between Chinese and Qatari samples, significantly stronger among the Chinese sample. The TTM dimensions explain a considerable amount of variance in attitude and self-efficacy. Self-efficacy further explains attitudinal changes. Firms should actively source and provide useful and accurate information about COVID 19, including pathological characteristics, propagation, prevention measures, and treatment. Besides, firms should promote the importance of following the guidelines, leaders should set examples, and encourage and empower employees to do so. With the right employee attitude and behavior, firms can manage pandemic-related disruptions within the organization and the supply chain. | N/A | 2022 | CORD-19 | |
| 2478 | Analysis of the COVID-19 pandemic's impacts on manufacturing: a systematic literature review and future research agenda The COVID-19 pandemic has affected manufacturing companies and necessitated adaptations of firms’ operations. Despite the increasing interest in this subject, a scarcity of systematic analysis can be observed. The present study systematically reviews the existing research on the COVID-19 pandemic concerning the manufacturing industry. This paper aims to highlight the main impacts of the COVID-19 pandemic on the manufacturing sector from the operations management perspective, the practical adaptation actions, and future research opportunities. Open research questions and directions for further investigation are articulated and triangulated across organisational, process and technology perspectives. | N/A | 2022 | CORD-19 | |
| 2479 | Adoption of innovative strategies to mitigate supply chain disruption: COVID-19 pandemic COVID-19 pandemic outbreak caused supply chain (SC) disruption and threatened human life across the world, which could be mitigated through innovative strategies. Based on this scenario, this study examines the impact of COVID-19 on green practices, SC crisis mitigation strategies, smart technologies, and sustainable supply chain performance in the Pakistani manufacturing industry. Data was collected from Pakistani firms and employed structural equation modeling for testing hypotheses. The empirical results found that the COVID-19 pandemic is statistically related to green practices, SC crisis mitigation strategies, and smart technologies, while it harms sustainable supply chain performance. Moreover, green practices, SC crisis mitigation strategies, and smart technologies positively contribute to sustainable supply chain performance. The results of this study also confirmed the mediating role of green practices, SC crisis mitigation strategies, and smart technologies and moderating role organizational commitment in the context of a developing economy’s manufacturing industry. This study enhances awareness and understanding and contributes to the existing literature on verifying the link between COVID-19 pandemic and green practices, SC crisis mitigation strategies, and smart technologies to increase sustainable supply chain performance during a pandemic disruption in the Pakistani context. This study supports the managers of supply chain and manufacturing firms in adopting green practices and smart technologies. Also, it helps in the formation and successful implementation of SC crisis mitigation strategies during the crisis. | N/A | 2022 | CORD-19 | |
| 2480 | Assessing supply chain resilience to the outbreak of COVID-19 in Indian manufacturing firms As the world has seen the impact of COVID-19, development of resilient supply chain strategies has emerged as top priority. The inconsistent demands, product consumption and the shorter lifecycle of products during the pandemic needs appropriate planning and designing to make the supply chain more resilient. In this study, an analytical model is proposed to assess the resilience of supply chain to overcome the effect of the disruption impacts. The supply chain risks will depend on the nature of the business and therefore, besides literature review on supply chain resilience the inputs from experts were required. The interdependency among the indicators was analysed by employing Interpretive Structural Modelling (ISM) and demonstrated with the help of a framework. The strength of the interdependence is assessed using Bayesian Network approach. BN transformed the qualitative expert inputs to quantitative assessment by utilising the principles of conditional probability. Three cases from Indian manufacturing industries were used to demonstrate and assess the critical supply chain resilience indicators using integrated ISM-BN approach. The cases showed that the proposed approach can assist decision makers in identifying the critical indicators to be focused towards improving the supply chain resilience to overcome the outbreak of Covid-19 pandemic. A comparative analysis of the supply chain risk indicators has also been performed, thereby extending the practical implication of supply chain resilience. | N/A | 2022 | CORD-19 | |
| 2481 | Investigating the interaction of factors for implementing additive manufacturing to build an antifragile supply chain: TISM-MICMAC approach The outbreak of the Covid-19 pandemic has come across as an exogenous shock to the firms and their supply chains. It has led firms to rethink and rework their existing robust and resilient supply chains. The purpose of this study is to move beyond robustness and resilience and shift to an antifragile supply chain that sees disorder as an opportunity to learn and grow. In this study, various factors to attain an antifragile supply chain have been identified through literature review and experts’ opinions. Using TISM-MICMAC, structural relationships among these factors have been developed, and, then the factors have been classified as drivers or dependents. The study reveals the importance of having proactive top management as a major driving power to build an antifragile supply chain. Development of a strategy for collaboration and innovation, development of a skilled workforce for technology adoption, and resource allocation for digitalization are some other factors with strong driving power. The novelty of the study lies in its effort to drive the attention of researchers and practitioners towards thinking beyond robustness and resilience and shifting towards antifragility. The study will help firms in strategic decision-making for the adoption of additive manufacturing technology to develop antifragility in the supply chain and save itself from negative consequences in the face of disruption. | N/A | 2022 | CORD-19 | |
| 2482 | Lessons from the COVID-19 pandemic: The case of retail and consumer service firms The COVID-19 pandemic has impacted business operations in every industry and sector around the world. Scholars, practitioners and policymakers continue to engage in understanding the effects of lockdowns, social distancing measures and other restrictions on trade; the impact of government stimulus and support measures, and how businesses have adapted their operations. The dynamic nature of the virus, and the changing socio-political and economic landscape, provide the opportunity for empirical scholarly research examining how retail and service firms have responded to the challenges and potential opportunities presented by the pandemic, and how owner/managers have pivoted in an (often) uncertain trading environment. This paper presents the findings of an applied study involving business owners (N = 268) of SME retail and service firms in the island state of Tasmania, in Australia, during the first wave of the pandemic in 2020. Findings show: (1) despite over 65 per cent of respondents reporting a downturn in revenue during 2020, almost 80 per cent indicated they had confidence in business survival heading into 2021; (2) whilst on average, businesses did not rate the level of environmental hostility as being particularly high, there was a significant correlation between perceived environmental hostility and assessment of business performance and with the level of confidence of business survival; (3) Australian federal government support and other stimulus measures were deemed crucial for business survival during 2020 with three quarters of businesses accessing the ‘JobKeeper’ scheme, and (4) businesses adapted their operations during the pandemic in terms of new products and services, increased marketing, pivoting their use of technology and promoting ‘localness’. | N/A | 2022 | CORD-19 | |
| 2483 | Synergic use of neural networks model and remote sensing algorithms to estimate water clarity indicators in Khanpur reservoir, Pakistan Freshwater reservoirs are limited and facing issues of over-exploitation, climate change effects and poor maintenance which have serious consequences for water quality. Developing countries face the challenge of collecting in situ information on ecological status and water quality of these reservoirs due to constraints of cost, time and infrastructure. In this study, a practical method of retrieval of two water clarity indicators, total suspended matter and secchi disk depth, using Sentinel-2 satellite data is adopted for preliminary assessment of water quality and trophic conditions in Khanpur reservoir, Pakistan. The study explores the synergy of utilizing two independent models, i.e., case 2 regional coast color analytical neural network model and semiempirical remote sensing algorithms to understand the spatiotemporal dynamics of water clarity patterns in the dammed reservoir, in the absence of ground measurements. The drinking water quality and trophic state of the reservoir water is determined based purely on satellite measurements. Out of the five months studied, the reservoir water has high turbidity and poor eutrophic status in three months. The results from both computational models are compared, which exhibit a high degree of statistical agreement. The study demonstrates the effective utilization of relevant analytical and semiempirical methods on satellite data to map water clarity indicators and understand their dynamics in both space and time. This solution is particularly useful for regions where routine ground sampling and observation of environmental variables are absent. | N/A | 2022 | CORD-19 | |
| 2484 | Echocardiographic and electrocardiographic findings in COVID-19 patients: a cross-sectional study There are still many gaps in our knowledge regarding the direct cardiovascular injuries due to COVID-19 infection. In this study, we tried to find out the effect of SARS-CoV-2 infection on cardiac function in patients without any history of structural heart disease by electrocardiographic and echocardiographic evaluations. This was a cross-sectional study on patients with COVID-19 infection admitted to Imam Reza hospital, Mashhad, Iran between 14 April and 21 September 2020. COVID-19 infection was verified by a positive reverse-transcriptase polymerase chain reaction (PCR) assay for SARS-CoV-2 using nasopharyngeal/oropharyngeal samples. We enrolled all patients over 18 years old with definite diagnosis of COVID-19 infection. All patients underwent a comprehensive transthoracic echocardiography at the first week of admission. Clinical and imaging data were collected prospectively. In total, 142 patients were enrolled in this study. The mean age of participants was 60.69 ± 15.70 years (range: 30–90 years). Most patients were male (82, 57.7%). Multivariate analysis showed that O2 saturation at admission was independently a predictor of re-hospitalization (P < 0.001). RV size (P < 0.001), dyslipidemia (P < 0.001), ejection fraction (EF) (P < 0.001), age (P = 0.020), systolic blood pressure (P = 0.001), O2 saturation (P = 0.018) and diabetes (P = 0.025) independently predicted 30-days mortality. Echocardiography can be used for risk assessment in patients with COVID-19, especially in those with previous history of diabetes and dyslipidemia. The infection could result in ventricular dysfunction, even in those without previous history of structural heart disease. | N/A | 2022 | CORD-19 | |
| 2485 | Kyle Harper, Plagues upon the Earth: Disease and the Course of Human History. John Mokyr, series ed. The Princeton Economic History of the Western World | Evol Med Public Health | 2022 | CORD-19 | |
| 2486 | El rol del profesional de enfermería en la nueva normalidad: ¿son la primera línea? | N/A | 2022 | CORD-19 | |
| 2487 | Hepatitis B and C screening in hospitalized patients with SARS-CoV-2 infection Aims To evaluate the results of a hepatitis B and C screening program in hospitalized COVID-19 patients. Method Transversal prospective study conducted in two Spanish hospitals. Patients admitted from March 1st to December 31st 2020 with a diagnosis of COVID-19 were tested for markers of hepatitis B (HBsAg, anti-HBc) and C (anti-HCV, HCV RNA) infection. Results In this period, 4662 patients with COVID-19 were admitted to our centers: 56.3% were male, median age was 76 (0–104) years. Data regarding HBV infection was available in 2915 (62.5%) patients; 253 (8.75%) were anti-HBc + and 11 (0.38%) HBsAg+. From these, 4 patients did not have a previous diagnosis of hepatitis B, 7 received corticosteroids and one received prophylaxis. There was one HBV reactivation. Anti-HCV were available in 2895 (62%) patients; 24 (0.83%) were positive. From these, 13 patients had a previous hepatitis C diagnosis: 10 patients had been treated with SVR, one achieved spontaneous cure and 2 did not receive treatment. From the 11 previously unknown anti-VHC + patients, 10 had a negative HCV RNA. Overall, only 3 (0.10%) patients tested RNA HCV + . However, none received HCV treatment (2 older than 90 years with comorbidities, 1 died from COVID-19). Conclusion Screening of hepatitis C infection in hospitalized COVID-19 patients seems less useful than expected. The low prevalence of active infection after antiviral treatments and the high age of our population limit the detection of potential candidates for treatment. HBV screening should be aimed to prevent reactivation under immunosuppressive treatments. | N/A | 2022 | CORD-19 | |
| 2488 | Pandémie de COVID-19: attachement, anxiété, régulation émotionnelle et stratégies de coping chez les enfants d'âge scolaire Introduction : Un impact de la pandémie de COVID-19 sur les émotions et comportements des enfants a été retrouvé dans plusieurs études. Cependant, cet impact n’a pas été retrouvé dans toutes les études. L’attachement pourrait être lié à des réactions et des niveaux d’anxiété différents. Objectif : L’objectif principal de cette étude était d’analyser les liens entre l’attachement insécure des enfants et les variables liées à l’anxiété et à la gestion émotionnelle et comportementale des enfants pendant la pandémie. Méthode : Les participants de l’étude (n=83 parents et leur enfant âgé de 6 à 12 ans) ont complété de façon anonyme des questionnaires en ligne évaluant l’insécurité d’attachement, l’anxiété-état, les stratégies de coping et la régulation émotionnelle. Ils ont également répondu à des questions socio-démographiques et liées à leur contexte de vie et vécu de la pandémie. Résultats : L’anxiété-état est liée de façon significative à la dysrégulation émotionnelle des enfants mais pas à la stratégie de coping tourné vers l’émotion. Des liens significatifs ont été observés entre l’insécurité d’attachement d’une part, et l’anxiété-état des enfants, la stratégie de coping tourné vers l’émotion et la dysrégulation émotionnelle des enfants d’autre part. La dysrégulation émotionnelle médiatiserait le lien entre attachement désorganisé et anxiété-état. Conclusion : Les liens entre l’insécurité d’attachement et l’anxiété-état des enfants d’une part, et à la stratégie de coping tourné vers l’émotion d’autre part montrent l’importance de prendre en compte les facteurs individuels et interactionnels dans les manifestations socio-émotionnelles des enfants pendant la pandémie de COVID-19. Introduction: An impact of the COVID-19 pandemic on the emotions and behaviors of children has been found in several studies. However, this impact is not found in all studies. Attachment could be linked to different reactions and levels of anxiety. Objective: The main aim of this study was to analyze the links between children’s insecure attachment and variables related to anxiety, emotional and behavioral management of children during the pandemic. Method: Study participants (n=83 parents and their child aged 6 to 12) completed anonymously online questionnaires assessing attachment insecurity, state-anxiety, coping strategies and emotional regulation. They also answered socio-demographic questions related to their context of life and experience of the pandemic. Results: State-anxiety is significantly related to children's emotional dysregulation but not to emotion-oriented coping strategy. Significant links were observed between attachment insecurity on the one hand, and children's state-anxiety, emotion-oriented coping strategy and children's emotional dysregulation on the other hand. Emotional dysregulation mediates the link between disorganized attachment and state anxiety. Conclusion: The links between attachment insecurity and children's state-anxiety on the one hand, and the emotion-oriented coping strategy on the other hand highlight the importance of taking individual and interactional factors into account in children's socio-emotional manifestations during the COVID-19 pandemic. | N/A | 2022 | CORD-19 | |
| 2489 | Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID orchitis in Brothers Introduction Little is known of SARS-CoV2 (COVID-19) pathogenicity, but organ inflammation syndromes have been well observed and documented in the lungs, heart, liver, kidneys, and testes. While the blood-testis barrier is known to protect testes from antigens, current evidence suggests COVID-19 can affect the testis. Reports of bilateral orchitis are growing. Current hypotheses consider causes of (1) cellular induced cytokine storm or (2) IgG deposits in the vascular endothelium to be at blame but causal genes or underlying genetic susceptibility have not yet been identified. Objective This project sought to uncover genetic explanations as to why certain men face increased susceptibility to developing COVID orchitis. Methods We identified and examined six COVID-19 patients who all were confirmed with polymerase chain reaction (PCR), including three COVID-19 (+) men without orchitis (controls) and three COVID (+) men with orchitis (bilateral testicular pain for at least 5 days around the time of testing PCR positive). Of note, among the three men with COVID-19 who had orchitis, two of them were siblings. DNA extraction and whole exome sequencing were performed on blood using the QIAmp blood maxi kit on five of the six patients. Variants were prioritized by being shared between the three patients affected with orchitis, absent in controls, and introducing nonsense, frameshift, splicing or non‐synonymous amino acid changes and less than 10% in population prevalence. Based on WES findings, DuoSet® Human ACE2 reagent kit 2 (catalog number: DY933-05) was purchased from R&D Systems, USA, and used to measure the level of soluble ACE2 in the plasma samples. Results The average age of the men in the study was 25 years old. The average duration of COVID symptoms (fever, sore throat, cough, body aches) were 7 days. Among the men who developed bilateral testis pain, the symptoms lasted for an average of 22 days. A list of 16 variants was generated that found to be shared between the two siblings with COVID orchitis along with the unrelated subject with COVID orchitis, and not present in the two controls. Among the 16 variants, a nonsynonymous non-frameshit deletion in NACAD variant on chromosome 7 with a frequency of 3.9% prevalence in ExAC was prioritized based on known involvement in the ACE2 pathway, read depth, and genotype quality. Phenotypically, we found that circulating levels of soluble ACE2 was 3.72 ng/ml among men who had COVID orchitis and was lower than men who developed COVID without orchitis. Conclusions We observed a stop mutation in NACAD in 2 brothers and 1 unrelated man who developed COVID orchitis. Interestingly, we found lower circulating ACE2 serum levels in both brothers with orchitis and the one nonrelated orchitis subject but normal serum levels in all controls. NACAD when involved with cellular ability to shuttle out ACE2 becomes critical for COVID symptomatology. With decreased transcellular and extracellular transport of ACE2 being possible in subjects with the gene mutation, it can be postulated more ACE2 will be found intracellularly leading to increased cellular entry of SARS CoV-2 and possibility of orchitis sequelae. Disclosure No | J Sex Med | 2022 | CORD-19 | |
| 2490 | The potential benefits of antihistamine therapy and exercise rehabilitation in women with post-COVID-19 syndrome | N/A | 2022 | CORD-19 | |
| 2491 | PM2.5 concentration prediction during COVID-19 lockdown over Kolkata metropolitan city, India using MLR and ANN models Kolkata is the third densely populated city of India and Kolkata stands in the World's 25 most polluted cities along with 10 worse polluted cities in India. The relevant study claims that due to the imposition of lockdown during COVID-19 pandemic, the atmospheric pollution level has been significantly reduced over the metropolitan city Kolkata like other cities of the world. The main objective of this study is to predict the concentration of PM2.5 using multiple linear regression (MLR) and artificial neural network (ANN) models and similarly, to compare the accuracy level of two models. The concentration of PM2.5 data has been obtained from state pollution control board, Govt. of West Bengal and daily meteorological data have been collected from the world weather website. The results show that non-linear artificial neural network model is more rational compared with multiple linear regression model due to its high precision and accuracy level (in respect to RMSE, MAE and R2). In this research artificial neural network (ANN) model exhibited higher accuracy during the training and testing phases (root mean square error (RMSE), mean absolute error (MAE) and R2 indicate 3.74, 1.14 and 0.91 respectively in training phase and 2.55, 4.32 and 0.69 in testing phase respectively). This model (ANN)) can be applied to predict the concentration of PM2.5 during the execution of urban air quality management plan. | N/A | 2021 | CORD-19 | |
| 2492 | Preocupaciones sobre la educación de los estudiantes de ciencias de la salud durante la pandemia por SARS-CoV-2 Introduction The pandemic suspended educational activities in more than 100 countries. This has had catastrophic consequences on the progress of individuals at all educational levels, causing delays and deficiencies in knowledge. The objective of the study is to identify and analyse concerns about the education of health sciences students during the SARS-CoV-2 pandemic. Materials and Methods A quantitative observational and cross-sectional study was conducted with an exploratory scope aimed at students in the field of health based on an analysis of primary data. A self-administered questionnaire was used as a collection tool. This population was studied using a semi-structured individual interview, with prior informed consent. Results A total of 2047 responses were obtained. The greatest concern of health students is not building the knowledge and skills necessary to exercise their professional activity. The predominant feeling is anxiety. Discussion The role of health sciences students is overlooked. We must change the way we provide education to students in times of crisis. | N/A | 2022 | CORD-19 | |
| 2493 | Impact of COVID-19 Pandemic in Online Interest in Erectile Dysfunction Introduction The COVID-19 pandemic has had a significant impact on global health. During uncertain times, priorities amongst patients shifted as many faced health concerns, economic uncertainty, and isolation. Access to general medical care during 2020 was challenging for many Americans who spent the year in quarantine. Without access to care, we hypothesize that patients were less likely to search for treatment options for a non-emergent condition like erectile dysfunction. Objective Herein, we aim to report on Google search trends observed in the pre COVID and post COVID era. Methods Google Trends was analyzed using search terms related to erectile dysfunction between June 2018 and June 2021. The search volume index (SVI), a relative measure of search volume on Google, was obtained for the following terms: erectile dysfunction, viagra, trimix, penile pump, and penile implant. Student t test was used to compare changes in mean SVI for each month compared to the same month one year prior. Results Compared to one year prior, the search for erectile dysfunction remained relatively stable over time with the exception of three months (9% decline Mar 2020, 38% increase Jan 2021, 8% increase Jun 2021). When compared to the preceding year, searches for Viagra declined during 9/37 (24%) months analyzed including Mar-Jun 2020, which coincided with the early part of the COVID-19 pandemic (p<0.05 for all). The only statistically significant increase occurred Oct 2020, a 16% change compared to Oct 2019 (p<0.05). In contrast, search for trimix did not change significantly over time except for an increase of 62% Mar 2021 and 60% Apr 2021 (p<0.05 for all). Search for the term penile pump did not change over time except for a 16 and 10% decline early during the pandemic, Feb and Mar 2020, respectively (p<0.05 for all). Lastly, search for penile implant declined 37% Mar 2020 and 32% Apr 2020 compared to 2019, and increased by 67% May 2021 compared to May 2020 (p<0.05 for all). Conclusions COVID-19 represented a major global health crisis, raising concerns and uncertainties for many. Erectile dysfunction remained a constant source of online interest. Despite limited access to medical care for elective conditions, only a few isolated increases in Google SVI were noted, most of which occurred during 2021 compared to 2020. This may be a reflection of the general public's lack of familiarity with treatments other than phosphodiesterase-5 inhibitors. Disclosure No | J Sex Med | 2022 | CORD-19 | |
| 2494 | Erosion of Inflatable Penile Prosthesis with Prolonged Foley Catheterization in the COVID-19 Era Introduction The COVID-19 pandemic has changed the lives of many in the past year. As of writing this article, the virus has claimed over half a million American lives and has infected millions more. It has affected many people regardless of age, gender, race, religion, or medical history. We have noticed a unique sequence of events in urology patients with a prior history of inflatable penis prothesis implantation who have gotten critically ill from the SARS-CoV-2 virus. Objective We report our experience with patients with an inflatable penile prothesis who suffered respiratory failure due to the SARS-CoV-2 virus and findings that would help limit the risk of implant infection and/or erosion if prolonged urethral catherization is needed. Methods We have encountered 3 patients with a very similar history in the past year. They were all men aged 57-72 years old who had a functioning inflatable penile prothesis (IPP) for many years (3-13) and were intubated for a prolonged period of time (2-4 weeks) after suffering respiratory distress from the SARS-CoV-2 virus. During this time, they all had a prolonged urethral Foley catherization for urinary drainage while in the ICU. They were all subsequently found to have urethral erosion of a penile implant cylinder which was not present prior to hospitalization. Their charts were reviewed. Results Two patients underwent explantation of their IPP during their hospital stay and one presented to our outpatient office 2 months after discharge with the complaint of urethral cylinder erosion and underwent subsequent explantation. Conclusions Urethral catheterization is commonly used in the intensive care unit and spinal cord injury patients due to their convenience and efficacy. The friction and inflammation created by prolonged transurethral catheterization can be disastrous for IPPs by increasing the likelihood of infection and/or device erosion. In fact, Steidle and Mulcahy found that five out of their nine patients (55%) with IPPs who had an indwelling or intermittent transurethral catheterization were eventually found to have erosion of their IPP. In addition, indwelling transurethral catheters also confer a higher risk of urinary tract infection. Han et al. found that suprapubic tube placement conferred a statistically significantly lower risk of urinary tract infection when compared to indwelling transurethral catheterization for over five days at an odds ratio of 0.142 (95% CI 0.073-0.0276). Another alternative to bladder drainage in the intubated IPP patient is clean intermittent catherization (CIC), however this poses a unique challenge in the intubated COVID positive patient as it repeatedly exposes healthcare staff the virus-carrying patient. When compared to indwelling transurethral catherization, suprapubic tube placement has been shown to confer a lower risk of urinary tract infection and IPP infection/erosion. This can primarily be explained by its ability to drain the bladder without creating inflammation and friction in the urethra. Therefore, we propose that any team caring for a patient with an IPP and a planned, prolonged indwelling transurethral catheterization consult urology services to have a suprapubic tube temporarily placed. This will ensure that the risk of urinary tract infection and/or IPP erosion is kept as low as possible. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, Boston Scientific, Neotract | J Sex Med | 2022 | CORD-19 | |
| 2495 | Face masks: protecting the wearer but neglecting the aquatic environment?-A perspective from Bangladesh In Bangladesh, as with many countries, the spread of COVID-19 made the wearing of single-use face masks, a non-pharmaceutical intervention to reduce viral transmission, surge in popularity amongst the general population. Consequently, irresponsible discarding of used masks into the environment, and mismanagement of the waste they produce, is potentially placing a large pollution burden on aquatic ecosystems in the country. Slow degradation of mask-derived polypropylene and polyethylene fibres creates large reservoirs of microplastic pollutants and these have acute and chronic effects on aquatic organism physiology. Using literature reviews, extrapolation of published data, and field observations, we present an emerging issue of pollution from COVID-19 personal protective equipment such as face masks in Bangladesh. We have estimated the volume of waste generated and document the potential consequences of its improper disposal, and subsequent degradation, in aquaculture ponds within country. In a field survey of 30 ponds in the Muktagacha upazilla, 76.7% were found to have plastics in contact with the water, or within 1m of the pond, and there was an average of 63 pieces of macro-plastic pollution per 5m2. This included floating discarded face masks. Bangladesh has a rich freshwater and marine resource which it depends upon for export trade, nutrition of the population, and jobs. To mitigate potential acute and chronic impacts on aquaculture and the environment, recommendations are made that, if adopted, would reduce entry of microplastics into the aquatic environments via face mask waste mismanagement. | N/A | 2021 | CORD-19 | |
| 2496 | Could COVID-19 Induced Endothelial Dysfunction Explain New Onset Peyronie's Disease? Introduction Coronavirus Disease 2019 (COVID-19) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV-2) which has been found to cause systemic inflammation in some patients. Many possible long-term sequelae of COVID-19 have yet to be identified. Since endothelial cells have both angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) receptors, and SARS-CoV-2 requires both receptors for cell entry, we hypothesized that widespread endothelial damage caused by COVID-19 infection leads to Peyronie's disease (PD). Objective New-onset PD after resolved COVID-19 infection was evaluated. Methods This study was performed after Institutional Review Board approval. After comprehensive history and physical exam, penile duplex was used to evaluate blood flow and characterize any plaques. International Index of Erectile Function (IIEF) was used to evaluate erectile function. Brachial artery flow-mediated dilation (FMD) and endothelial progenitor cell – colony forming units (EPC-CFU) assays were utilized as measures of endothelial function. Available data from two separate control groups were used for comparisons: “No PD” contains subjects with a history of cardiovascular disease and normal erectile function according to IIEF-EF score (n=27). This group was selected to serve as a negative control with endothelial dysfunction. A second control group “Healthy Controls” was selected as a positive control containing male participants who were free from any significant cardiovascular medical history (n=9). Results New-onset PD after resolution of COVID-19 infection was identified in one patient. The penile duplex with erectogenic agents demonstrated normal vascular flow with presence of calcified plaques. The PD group median EPC-CFU levels were 0 as compared to 1.60 in the no PD (negative control) group and 20.00 in healthy (positive) controls. Similarly, median FMD% was impaired in the PD group (2.35%) and no PD group (3.88%) as compared to healthy controls (7.75%). Conclusions These findings reveal a novel mechanism for PD after resolution of COVID-19 infection. These findings have significant clinical and biological implications for males with PD and should be considered as a possible sequela of COVID-19 infection. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Acerus Pharmaceuticals, Boston Scientific, Coloplast, Endo Pharmaceuticals, Empower Pharmacy, Nestle Health, Olympus | J Sex Med | 2022 | CORD-19 | |
| 2497 | Santé publique: des défis à relever ! | N/A | 2022 | CORD-19 | |
| 2498 | Isolated cerebral mucormycosis in post-COVID-19 pneumonia Background : Rhino-orbital-cerebral and isolated cerebral involvement of basal ganglia by mucormycosis are two different manifestations of CNS mucormycosis. The former variant caused by inhaled fungal spores and is common with immunosuppressive conditions. The latter form is caused by intravascular inoculation of spores as seen in intravenous drug abusers. Case report : Here we describe a case of young, non-addict patient with a history of recent mild COVID-19 pneumonia who presented with isolated cerebral mucormycosis involving bilateral basal ganglia. Discussion : The pulmonary vasculitis associated with COVID-19 is probably the cause of direct intravascular entry of inhaled fungal spores leading to direct isolated cerebral involvement. Such condition may rapidly turn fatal. Conclusion : This is the first reported case of isolated cerebral mucormycosis following post-COVID-19 infection. Early tissue diagnosis and intravenous amphotericin B is the key management. | N/A | 2022 | CORD-19 | |
| 2499 | COVID-19 is Associated with New Onset Erectile Dysfunction: Insights From a Multinational Registry Introduction As the COVID-19 pandemic has been ongoing since 2019, we are just beginning to see some of the short and long-term effects of infection. Vascular integrity is necessary for erectile function, and endothelial damage associated with COVID-19 is likely to affect the penile vasculature. Recent studies have showed evidence of COVID-19 virus within penile tissue through electron microscopy. We hypothesized that the COVID-19 infection may be a contributing factor to subsequent development of erectile dysfunction (ED). Objective To determine if men with recent COVID-19 infection was associated with subsequent increased risk for development of erectile dysfunction. Methods We assessed the risk of ED in men with COVID-19 in the United States (US) using the TriNetX Research Network, a federated EMR network of over 42 healthcare organizations and 66 million patients from the US, from 2009-2020. We identified adult men (≥18 years) with a recorded COVID-19 infection (ICD-10-CM B34.2, U07.1, U07.2, J12.81, J12.82, B97.29) since January 1, 2020 and compared them to an equivalent number of adult men who had COVID-19. Men with prior history or diagnosis of ED were excluded. We accounted for confounding variables through propensity score matching for age, race, body mass index (BMI), and history of the following comorbid medical conditions: diabetes mellitus (ICD-10-CM E11), hypertension (ICD-10-CM I10), or hyperlipidemia (ICD-10-CM E78). We assessed the association between COVID-19 and ED (ICD-10-CM N52) as a primary outcome through regression analysis with statistical significance assessed at p<.05. Results Prior to propensity score matching, men with COVID-19 had an average age of 47.1 + 21.4 years, 13% had diabetes mellitus, and 27% had hypertension, while in men without COVID-19, average age was 42.4 + 24.3 years, 7% had diabetes, and 22% had hypertension. After propensity score matching, we compared 230, 517 men with COVID-19 to 232,645 men without COVID-19 and found that COVID-19 diagnosis was significantly associated with ED (OR 1.120, 95% CI 1.004-1.248, p=0.0416). Strengths include large sample size and adjustment for confounding variables. Limitations include lack of data regarding ED (mild vs moderate vs severe) or COVID-19 infection severity. Conclusions Our study showed that there is an increased risk of developing ED post-COVID infection, suggesting possible long-term effects due underlying endothelial dysfunction. The exact mechanism of how COVID-19 virus leads to erectile dysfunction remains to be elucidated. Disclosure No | J Sex Med | 2022 | CORD-19 | |
| 2500 | Concerns About Fertility Found to Be Major Cause Of COVID-19 Vaccine Hesitancy in the United States Introduction As of July 2021, three vaccines have been issued Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration (FDA) to combat SARS-CoV-2 with over 65% of U.S. adults having received at least one vaccine dose. However, up to 35% of the population are hesitant or refuse to get vaccinated. As reproductive toxicity studies were not conducted prior to EUA, adults have expressed concern about potential adverse effects of the vaccines on fertility and reproductive health. Objective We evaluated the current reasons for COVID-19 vaccine hesitancy among the unvaccinated U.S. population and identified their demographic characteristics. Methods Amazon Mechanical Turk (MTurk) was used to survey the vaccine hesitancy reasons amongst unvaccinated U.S. adult population between June 30, 2021-July 1, 2021. The project title listed for survey participants during distribution was “Covid-19 Vaccine Hesitancy Survey”. The study was reviewed by the Institutional Review Board, and it was deemed an exemption. Users with addresses in the U.S., over the age of 18, and received no doses of any coronavirus vaccine at any time were invited to complete an anonymous 32-question survey with an estimated completion time of less than 10 minutes. The first part of the survey focused on identifying attitudes toward the COVID-19 vaccines while the latter queried demographic information such as age, race/ethnicity, and relationship status. Quantitative data was analyzed using by two-sample Z-test on Microsoft Excel (version 16.44) and MATLAB (version R2021a). Results A total of 914 unvaccinated adults completed our survey (response rate 91.4%) with 53% of respondents identifying as cis-male and 42% as cis-female. Of the participants, 58% indicated ‘COVID-19 vaccine side effects or other potential unknown long-term effects’ as their reason for remaining unvaccinated and 39% of them believed that ‘COVID-19 vaccines can negatively impact reproductive health and/or fertility’. Among those participants that were concerned that COVID-19 vaccines could impact fertility, 42% (p = 0.010) lived in urban settings, 46% (p > 0.001) were married, and 38% (p = 0.020) of individuals were born outside of the U.S. About 1/2 of the participants stated that more information and research conducted on the COVID-19 vaccines would encourage them to get vaccinated. Conclusions A large portion of the U.S. population remain fearful of the potential side effects associated with the coronavirus vaccines and more specifically negative impacts to their future reproductive health. These results objectively evidence that fertility concerns are significantly contributing to vaccine hesitancy and may continue to be a barrier for years to come if no interventions are made. With almost half of the participants yearning for more information and research this highlights the need for intense investigation and publicly available data on the effect of coronavirus vaccines on fertility. Disclosure No | J Sex Med | 2022 | CORD-19 |
(1) COVID-19 Open Research Dataset (CORD-19). 2020. Version 2022-06-02. Retrieved from https://ai2-semanticscholar-cord-19.s3-us-west-2.amazonaws.com/historical_releases.html. Accessed 2022-06-05. doi:10.5281/zenodo.3715506
(2) Chen Q, Allot A, & Lu Z. (2020) Keep up with the latest coronavirus research, Nature 579:193 and Chen Q, Allot A, Lu Z. LitCovid: an open database of COVID-19 literature. Nucleic Acids Research. 2020. (version 2023-01-10)
(3) Currently tweets of June 23rd to June 29th 2022 have been considered.