This version of BIP! Finder aims to ease the exploration of COVID-19-related literature by enabling ranking articles based on various impact metrics.
Last Update: 18 - 01 - 2023 (628506 entries)
Popularity: Citation-based measure reflecting the current impact.
Influence: Citation-based measure reflecting the total impact.
Reader Attention: The current number of Mendeley readers.
Social Media Attention: The number of recent tweets related to this article.
*More details on these impact measures can be found here.
Exceptional score (in top 0.01%).
Substantial score (in top 1%).
Average score (in bottom 99%).
Score not available.
CORD-19 dataset(1) (list of papers)
LitCovid hub(2) (list of papers)
PMC & PubMed (citations)
Mendeley (number of readers)
COVID-19-TweetIDs(3) (tweets)
| Title | Venue | Year | Impact | Source | |
|---|---|---|---|---|---|
| 1451 | The sustainability of multinational enterprises' pandemic induced social innovation approaches The COVID‐19 pandemic has prompted an unprecedented reaction in several multinational enterprises (MNEs). These MNEs have adopted social innovation approaches to meet the needs of vulnerable societal groups by swiftly innovating their business models; drastically changing their product offerings and customer bases; and producing COVID‐19 necessities. These approaches have alleviated some key pandemic‐induced social challenges related to health and sanitation. In this perspective article, we use secondary sources of information to present and exemplify the various types of MNE pandemic‐induced social innovation approaches. We open the discussion on whether these approaches are transitory in nature or whether they can and should be sustained in the long‐term, given the right incentives to these MNEs. We conclude by redefining MNEs' social innovation and by suggesting avenues for scholars, practitioners, policymakers, and educators to support this momentum in MNEs which we argue, if sustainable, can be fruitful for addressing other pressing grand challenges such as climate change, food security, poverty, and inequality. | N/A | 2022 | CORD-19 | |
| 1452 | 5 The Great Disrupter: COVID-19's Impact on Migration, Mobility and Migrants Globally | N/A | 2022 | CORD-19 | |
| 1453 | Covid! It's the Chinese! No! It's the 'others' | Polit Q | 2022 | CORD-19 | |
| 1454 | Is Covid-19 changing sustainable consumer behavior? A survey of Italian consumers Since the beginning of 2020, the world has been hit by the SARS‐CoV‐2 virus that causes Covid‐19. To hamper its spread, policymakers of many countries have put in place strong countermeasures, including lockdowns, that have led to significant changes in people's lifestyles and daily routines. This article aims at assessing the changes caused by Covid‐19 in sustainable consumer behavior under multiple perspectives, contributing to advance knowledge at the intersection between consumer dynamics and sustainable consumer behavior literature. A survey was conducted on 1.535 Italian consumers between December 2020 and February 2021. Respondents were asked to assess the extent to which their consumption behavior—purchase frequency, willingness to pay a premium price, sense of moral duty to purchase, social influence to purchase—related to several categories of sustainable products changed due to the pandemic, as well as the extent to which the pandemic impacted on many other aspects, including their environmental awareness, concern, and habits. Results show that Covid‐19 generated relevant changes. Consumers have increased their purchase frequency and willingness to pay for sustainable products, show growing attention to environmental issues, and behave more sustainably. Further, the extent of change is strongly affected by socio‐demographic variables, such as gender, age, income, and education. For instance, women reported a higher shift towards sustainable consumption and behavior than men. Understanding these changes is important to guide marketers and policymakers to respond promptly and effectively to them and to leverage on them to foster a transition towards a more sustainable society. | N/A | 2022 | CORD-19 | |
| 1455 | Institutional Investor Heterogeneity and Corporate Response to the Covid-19 Pandemic We examine the role of institutional investors in determining firms’ decisions whether to reduce dividends and share buybacks during the Covid‐19 pandemic. Our simple model predicts that the probability of cuts in payouts is linked to the holdings and types of institutions. We link our model to the attention‐based theories of the firm. We posit that the highly proximate nature of the pandemic may encourage greater risk aversion in organizations. Consequently, the presence of institutions that actively engage with managers results in a reduction in shareholders’ payouts during the pandemic to enable firms to deal with increased uncertainty, while institutions that seek short‐term value releases reduce the probability of cuts. We test our hypotheses using novel hand‐collected data on shareholders’ payout cuts in the UK during the Covid‐19 lockdown. We find that in firms with larger institutional holdings, shareholders’ payouts are more likely to be reduced as a response to the pandemic. However, institutional heterogeneity matters as institutions with a view to improve firms’ long‐term growth are more likely to affect corporate payout decisions. In contrast, institutions that focus on regular income (e.g. pension funds) seem to resist cuts even in the aftermath of a severe exogenous shock like the Covid‐19 pandemic. | N/A | 2022 | CORD-19 | |
| 1456 | Building community resilience during COVID-19: Learning from rural Bangladesh The COVID‐19 pandemic has brought overwhelming challenges to developing countries which are already resource‐constrained and lack adequate social safety nets. Specifically, lockdown has adversely impacted marginalized communities (e.g., labourer, fish wholesaler and small business owner) and informal sector employees who rely on meager daily wages for their survival. Set in the contested climate of the emergency response to the COVID‐19 outbreak in Phulbari, Dinajpur, Bangladesh, we examine the early response of the community to the pandemic. Drawing on 24 in‐depth interviews with members of this community, we find that the existing central and regional government structure has failed to deal with the crisis. Yet, we show how collective effort at the local community level, led by volunteers and community leaders, is crucial in the fight against hardship during lockdown. | N/A | 2022 | CORD-19 | |
| 1457 | The COVID-19 pandemic and students' mental health In this article, authors outline the prevalence of mental health disorders among students during the pandemic, highlight common strategies embedded in campuses’ responses, and provide recommendations for campuses to support students’ mental health. | N/A | 2022 | CORD-19 | |
| 1458 | Modeling the impact of the COVID-19 outbreak on environment, health sector and energy market The global outbreak of COVID‐19 disease had a significant impact on the entire globe. Such a notable public health event can be seen as a “black swan” that brings unpredictable and unusual forces into the economic context and that it could typically lead to a chain of adverse reactions and market disruptions. Hence, the purpose of this study is to examine how COVID‐19 affects the environment, health, and the oil and energy markets. To achieve this objective, we used daily data for several measures that refer to the environment, health, and oil and energy, for the first wave of the COVID‐19 pandemic (December 31, 2019–May 22, 2020). The variable integration mix led to the approach of the ARDL model, and the Granger causality test was also employed. These empirical techniques allowed us to examine the cointegration between variables and causal relationships. The econometric results of the ARDL models exhibited that the global new cases and new deaths of COVID‐19 have short and long‐term effects on the environment, the health sector, the oil, and energy measures. However, no significant causal connection was found between the pandemic and the environment, the health sector, or the oil and energy industry, according to the Granger causality test. The uniqueness of current approach consists in the investigation of pandemic impact on the health, environment, oil, and energy sector by applying the ARDL model that permits the analysis of cointegration both in the long run and in the short term. This study provides important insights for investors and policy makers. | N/A | 2022 | CORD-19 | |
| 1459 | Antibody therapies to prevent and treat COVID-19 There are numerous biological and small‐molecule therapies currently under investigation for the prevention and treatment of COVID‐19. This article focuses on antibody therapies that target the virus itself, including convalescent plasma and monoclonal antibodies against SARS‐CoV‐2, and discusses their efficacy in clinical trials and likely future role. | N/A | 2022 | CORD-19 | |
| 1460 | Exploring graduate student roles and responsibilities in enhancing sense of belonging in residence life during COVID-19 Based on an autoethnographic study, this article aims to better understand how graduate student residence life staff made sense of their responsibilities and roles in enhancing student belonging within residence halls. The article also explores how the graduate students’ own sense of belonging was impacted as a result of COVID‐19 policy. | N/A | 2022 | CORD-19 | |
| 1461 | Paxlovid: antiviral combination for the treatment of COVID-19 Paxlovid (nirmatrelvir/ritonavir) is an oral antiviral combination for the treatment of COVID‐19 in adults at risk of progression to severe disease. This article summarises its indications, interactions and efficacy. | N/A | 2022 | CORD-19 | |
| 1462 | Evaluating the risk of SARS-CoV-2 transmission to bats in the context of wildlife research, rehabilitation and control Preventing wildlife disease outbreaks is a priority for natural resource agencies, and management decisions can be urgent, especially in epidemic circumstances. With the emergence of SARS‐CoV‐2, wildlife agencies were concerned whether the activities they authorize might increase the risk of viral transmission from humans to North American bats, but had a limited amount of time in which to make decisions. We describe how decision analysis provides a powerful framework to analyze and reanalyze complex natural resource management problems as knowledge evolves. Coupled with expert judgment and avenues for the rapid release of information, risk assessment can provide timely scientific information for evolving decisions. In April 2020, the first rapid risk assessment was conducted to evaluate the risk of transmission of SARS‐CoV‐2 from humans to North American bats. Based on the best available information and relying heavily on expert judgment, the risk assessment found a small possibility of transmission during summer work activities. Following that assessment, additional knowledge and data emerged, such as bat viral challenge studies, that further elucidated the risks of human‐to‐bat transmission and culminated in a second risk assessment in the fall of 2020. We updated the first SARS‐CoV‐2 risk assessment with new management alternatives and new estimates of little brown bat (Myotis lucifugus) susceptibility, using findings from the fall 2020 assessment and other empirical studies. We found that new knowledge led to an 88% decrease in the median number of bats estimated to be infected per 1,000 encountered when compared to earlier results. The use of facemasks during, or a negative COVID‐19 test or vaccination prior to, bat encounters further reduced those risks. Using a combination of decision analysis, expert judgment, rapid risk assessment, and efficient modes of information distribution, we provided timely science‐based support to decision makers for summer bat work in North America. | N/A | 2022 | CORD-19 | |
| 1463 | Reimagining and redesigning teaching and learning in the post-pandemic world The pandemic has provided a unique window of opportunity for higher education institutions to change because of the disruptions in normal ways of operating. The pandemic crisis has created opportunities to revise our strategies, internal and external partnerships, teaching methods, student pathways and recruitment approaches, incentive systems, faculty expertise, assessment approaches, and overarching goals of higher education. This article discusses a proactive stance suggesting that higher education must respond not only to the past, not even to the present, but to future needs. | N/A | 2022 | CORD-19 | |
| 1464 | In silico screening of natural antivirals as potential inhibitors of SARS-CoV-2 virus Coronavirus infectious disease 2019 (COVID‐19) is an infectious disease of the human respiratory tract caused by the SARS‐CoV‐2 virus. Spike protein is a class I glycoprotein trimeric TM involved in viral entry and infection. Four major targets to inhibit the SARS‐CoV‐2 virus are spike protein, angiotensin‐converting enzyme 2 (ACE2), main protease and the enzyme RNA‐dependent RNA polymerase (RdRp). In this study, we evaluated the inhibitory potential of natural antiviral compounds against spike protein, ACE2, main protease, RdRp targets by molecular docking and molecular dynamics simulations. Lipinski Rule of Five was used to evaluate the drug‐like properties of these compounds. The pkCSM tool was used to assess the pharmacokinetic parameters of prospective substances. Based on the ChemFaces database, we have collected 273 natural antiviral compounds. The results showed that the 7/273 compounds with the most potential to inhibit SARS‐CoV‐2 were: hinokiflavone, sotetsuflavone, mulberroside C, daphnoretin, morellic acid, digitoxin, and hypericin. Among them, sotetsuflavone is the most potent compound that inhibits four targets, with drug‐like properties, good intestinal absorption, and low toxicity. The molecular dynamics simulation results of the complexes are also relatively stable. As a results, in vitro and in vivo test should be carried out to verify the potential for COVID‐19 treatment of this compound. | N/A | 2022 | CORD-19 | |
| 1465 | A community of care: Student conduct during the Covid-19 pandemic During the COVID‐19 pandemic, universities adjusted policy and protocols to manage the environment and mitigate the risk of virus transmission among the campus community. In the early semesters of the pandemic, these changes restricted student behavior that would have otherwise been encouraged, such as attending gatherings, and often resulted in conduct violations that had penalties, including removal from campus. This article will explore how one university implemented a Community of Care ethos to promote the health, safety, and wellbeing of the campus community and will identify the challenges and lessons learned during the COVID‐19 pandemic. | N/A | 2022 | CORD-19 | |
| 1466 | Impact of COVID-19 lockdown on the elemental profile of PM10 present in the ambient aerosol of an educational institute in Kolkata, India Reduction in air pollution level was prime observation during COVID‐19 lockdown globally. Here, the study was conducted to assess the impact of lockdown on the elemental profile of PM(10) in ambient aerosol to quantify the elemental variation. To quantify the variation, phase‐wise sampling of air pollutants was carried out using the gravimetric method for PM(10), while NO(2) and SO(2) were estimated through the chemiluminescence and fluorescent spectrometric method respectively. The elemental constituents of PM(10) were carried out using an Inductively Coupled Plasma Optical Emission Spectrometer and their source apportionment was carried out using the Positive Matrix Factorization model. The results showed that PM(10), NO(2) and SO(2) reduced by 86.97%, 83.38%, and 88.60% respectively during the lockdown sampling phase. The highest mean elemental concentration reduction was found in Mn (97.47%) during the lockdown. The inter‐correlation among the pollutants exhibited a significant association indicating that they originate from the same source. The metals like Mn and Cu were found at a higher concentration during the lockdown phase corresponding to vehicular emissions. The comparative analysis of the elemental profile of PM(10) concluded that the lockdown effectuated in reduction of the majority of elements present in an aerosol enveloping metropolitan like Kolkata. | N/A | 2022 | CORD-19 | |
| 1467 | A natural disaster student support program for online students faces the challenge of COVID-19 This article describes Western Governors University's emergency management student support program in place prior to the pandemic and the challenge to adapt and address the unprecedented needs students faced due to COVID‐19. Included are key lessons learned in addressing the impact of COVID‐19 and evidence‐based learnings in response to the large‐scale student needs during the prolonged pandemic. | N/A | 2022 | CORD-19 | |
| 1468 | From pandemic to endemic pedagogy: Being CLEAR in our teaching In this chapter, I consider what might happen if the pandemic acts as a portal for teaching and learning in higher education. I suggest the need to make commitments to five interlocking characteristics of post‐pandemic pedagogy: Context, Learning, Equity, Agency, and Relationships. The future of teaching and learning, in short, is CLEAR. | N/A | 2022 | CORD-19 | |
| 1469 | Sustainable practices in hospitality pre and amid COVID-19 pandemic: Looking back for moving forward post-COVID-19 Sustainability issues are becoming increasingly important in the hospitality sector during crisis times such as COVID‐19 and post‐pandemic. In order to synthesize the literature on sustainable practices in hospitality, we developed a systematic literature to illustrate the dominant sustainable practices in hospitality. We present a comprehensive review of the 48 articles on sustainable practices in hospitality through the Web of Science (WoS) and Scopus databases; spanning over 2 years (2020–2021) pre‐and amid the COVID‐19 pandemic and extending the scope in distinctive ways. Our review has demonstrated that sustainable practices in hospitality have made progress in the years 2020 and 2021. However, there are conceptual and empirical overlaps among sustainable practices in hospitality. Additionally, hospitality sustainable practices research is restricted in research contexts. There is a lack of research on antecedents, outcomes, and integrating theories in studies. By following the guidance presented in this review, we expect to advance and maintain sustainable practices research to provide substantive insights over the coming years post‐COVID‐19. The current research is one of the first studies to systematically review sustainable practices in hospitality pre‐and amid the COVID‐19 pandemic. The research ends with a comprehensive research agenda and a framework to apprise future theoretical and empirical advances in the area. | N/A | 2022 | CORD-19 | |
| 1470 | Research shows impact of COVID-19 on students with disabilities, other groups “This Report bears witness to the many ways that COVID‐19, with all of its tragic impacts on individuals, families, and communities, appears to be deepening divides in educational opportunity across our nation's classrooms and campuses,” states the opening message from Acting Assistant Secretary of Education Suzanne B. Goldberg in Education in a Pandemic: The Disparate Impacts of COVID‐19 on America's Students. | N/A | 2022 | CORD-19 | |
| 1471 | Application of layers of protection analysis to prevent coronavirus infection Layers of protection analysis (LOPA) methodology is applied to an encounter with the SARS‐COV‐2 infection as an initiating event, and subsequently, independent protection layers (IPLs) (namely health safeguarding protocols), such as social distancing, ventilation, hand hygiene, face masks, and vaccinations. LOPA is applied considering numerical quantification of the COVID fatality index in order to manage the transmission risk to a tolerable level, namely the fatality risk due to seasonal flu. This measurement tool quantifies the ratio of the annual death rate due to the SARS‐COV‐2 infection to the annual death rate of the common flu, and it is applied to a chemical plant. The lower this quantified value is, the more the COVID‐19 infection death rate approaches that of the common flu. Thus, any improvement in safeguarding protocols should reduce this index. The input data is based on public domain COVID‐19 infection statistical data and websites accessible in the United Kingdom. The COVID‐19 transmission rate is statistically analyzed with random number sampling to simulate the random pattern of the virus' person‐to‐person infection in the community. The success of the COVID‐19 protection protocols is probabilistic and depends on the public's compliance, which is modeled by observational surveys. | N/A | 2022 | CORD-19 | |
| 1472 | Mitteilungen des ÖWAV | N/A | 2022 | CORD-19 | |
| 1473 | Development of IgA vasculitis after SARS-CoV-2 vaccination We report a case of IgA vasculitis that occurred 1 week after COVID‐19 vaccination. Like influenza vaccine, SARS‐CoV‐2 vaccine is considered to have a potential to produce immune complexes with IgA. Given that patients with a history of IgA vasculitis may be flared up following SARS‐CoV‐2 vaccination, individuals with a history of IgA vasculitis should be carefully followed up after receiving the vaccine. [Image: see text] | N/A | 2022 | CORD-19 | |
| 1474 | Rare earth elements in surface waters and sediments of the Mgoua watershed, south western Cameroon The concentrations and distribution spectra of 14 stable rare earth elements (REE) were studied for surface waters (n = 30) and sediments (n = 30) of the tropical zone Mgoua watershed in southwest of Cameroon. Samples were analyzed using the inductively coupled plasma mass spectrometer (ICP-MS) method. The ∑REE concentrations of the surface waters vary from 0.11 to 6.60 µg/L with an average value of 1.18 µg/L. This average is 150 times lower than the average values of the Post-Archean Australian Average Shale (PAAS). In the sediments, the concentrations range from 282.12 to 727.67 ppm with an average value of 550.05 ppm, making it 2.5 times higher than the PAAS. Rare earth spectra normalized to PAAS are spread out and show heavy rare earth enrichment; positive Eu anomalies; negative, low, or no Ce anomalies; and a gradual decrease in heavy earths in river and well waters and sediments, but are sawtooth with strong negative Ce anomalies in effluent waters and sediments. A low rare earth fractionation is noted in river and well waters [(La/Yb)(N) ~ 0.35–1.19], while it is high in effluent waters [(La/Yb)(N) ~ 0.42–56.99]; a slight depletion of rare earths in all environments [(La/Sm)(N) ~ 0.69–2.35], as well as a depletion of heavy rare earths [(Gd/Yb)(N) ~ 0.58–1.94]. In the sediments, the same characteristics are found with elemental ratio values differing slightly [(La/Yb)(N) ~ 1.15–1.99]; [(La/Sm)N ~ 0.75–1.36]; and [(Gd/Yb)(N) ~ 1.15–2.01]. This study shows that the Mgoua watershed does not have a high concentration of REE, although in the sediments they are well above the average PASS value while they are insignificant in the waters. | N/A | 2022 | CORD-19 | |
| 1475 | U.S. network and low-cost carriers' performance in response to COVID-19: Strictness of government policies and passengers' panic Coronavirus outbreak has been highly disruptive for aviation sector. There is strong correlation between COVID-19 related news, volatility in transportation, low confidence in travel safety, and uncertainty in this era. In this research, we study and distinguish the COVID-19's impact on U.S. airlines' performance. The network and low-cost carriers responded differently to it in terms of capacity reduction, market share reduction, scheduled flights reduction, flight cancellations, and service quality in the year 2020. We illustrate low-cost carrier had higher efficiency compared to network ones during pandemic by applying Network Data Envelopment Analysis. Furthermore, the effects of two key factors that emerge from COVID-19, the government's stringency actions and passengers' panic, on U.S. airlines efficiency are studied. Our analysis demonstrate that the negative effect is more significant for passengers' panic than it is for governments' stringency measures. In addition, we show that passengers' panic has more impact on the efficiency of network carriers compared to low-cost carrier. | N/A | 2022 | CORD-19 | |
| 1476 | Nutritional therapy for hospitalized patients with COVID-19: A narrative and integrative review Hospitalized patients affected by coronavirus disease 19 (COVID-19) have a sustained pro-inflammatory state and recurrent gastrointestinal symptoms that correlate with a decline in the nutritional status, which is directly related to poor immune response and clinical evolution. Nutritional therapy has proven crucial in COVID-19 treatment through the provision of adequate amounts of nutrients. Since the beginning of the pandemic, medical societies have mobilized to provide practical nutritional guidelines to support decision-making; despite this, there are only a few studies dedicated to compiling the most relevant recommendations. In this narrative review, we aimed to summarize and stratify the current scientific literature on nutritional support for hospitalized COVID-19 patients. We carried out a literature review from three databases between January 2020 and July 2021, using nutrition therapy (or medical nutrition or enteral nutrition or parental nutrition or nutritional support) and COVID-19 (SARS-CoV-2 infection) as the search terms. Only those studies that evaluated adult hospitalized patients with admissions to wards, specific clinics, or intensive care units were included. The nutritional intervention considered was that of specific nutritional support via oral, enteral, or parenteral modes. A total of 37 articles were included. In general, the nutritional care provided to COVID-19 patients follows the same premises as for other patients, i.e., it opts for the most physiological route and meets nutritional demands based on the clinical condition. However, some protocols that minimize the risk of contamination exposure for the health team have to be considered. Energy requirements varied from 15 kcal -1kg -1day-1 to 30 kcal -1kg -1day-1 and protein goals from 1.2 g -1kg -1day-1 to 2 g -1kg -1day-1. In both cases, the ramp protocol for increased supply should be considered. In cases of enteral therapy, ready-to-use diet and continuous mode are recommended. Attention to refeeding syndrome is essential when parenteral nutrition is used. | N/A | 2022 | CORD-19 | |
| 1477 | The impacts of gradually terminating nonpharmaceutical interventions for SARS-CoV-2: A mathematical modelling analysis With the expansion of vaccination programs, the policy of terminating nonpharmaceutical interventions for preventing the SARS-CoV-2 pandemic should become more flexible. The current study investigated the clinical and economic outcomes of intervention policies combining nonpharmaceutical interventions and vaccination programs for dealing with the SARS-CoV-2 pandemic. An agent-based transmission model was adopted that describes how a SARS-CoV-2 virus spreads in the populations of China. The model inputs were derived from the literature and expert opinion. The following intervention policies were simulated: no intervention, strict nonpharmaceutical interventions, and nonpharmaceutical interventions for workplace, community, school and home gradually terminated by combining vaccination programs for specified age groups (vaccination age in years: 20–60, 20–70, 20–80, ≥20, ≥10 and whole population). Cumulative infections and deaths in one calendar year, costs and quality-adjusted life years (QALYs) were measured. When the vaccination program was taken up in at least the ≥20 years age group in all populations, nonpharmaceutical interventions for workplace and community settings could be gradually terminated because the cumulative number of infections was < 100 per 100,000 persons. Further ending nonpharmaceutical interventions in school and home settings could not meet the target even when the vaccination program had been taken up in all populations. When cumulative deaths were used as the endpoint, nonpharmaceutical interventions in workplace, community and school settings could be gradually terminated. Vaccine efficacy and coverage have substantial impacts. Terminating nonpharmaceutical interventions in workplace settings could produce the lowest cost when vaccination programs are taken up at least in the ≥10 years age group; this method dominates most intervention strategies due to its lower costs and higher QALYs. According to our findings, nonpharmaceutical interventions might be gradually terminated in Chinese settings. | N/A | 2022 | CORD-19 | |
| 1478 | A Tale of Two Pandemics: Cancer Coping and Care Delivery During the COVID-19 Pandemic (RP402) Outcomes 1. Understand how to prepare cancer and palliative care delivery systems for future COVID-related surges or pandemics that necessitate changes in delivery of cancer and palliative care services 2. Understand cancer and palliative care clinician burnout Importance The COVID-19 pandemic profoundly disrupted cancer and palliative care delivery. Objectives Use mixed methods to explore the impact of the pandemic on cancer and palliative care delivery among cancer patients, family caregivers, and cancer and palliative care clinicians. Methods Quality-of-life and COVID-specific surveys were distributed to cancer patients and family caregivers in four US geographic areas. In-depth interviews were conducted with cancer patients, family caregivers, and cancer and palliative care clinicians. Results From August 2020 through July 2021, data were collected in Baltimore, MD; Boston, MA; Albuquerque, NM; and Stanford, CA and include 499 surveys from 188 cancer patients and 26 family caregivers and 71 interviews from 48 cancer patients, 4 family caregivers, and 19 cancer and palliative care clinicians. Participants included patients who were recently diagnosed, those who were undergoing active anticancer treatment or had completed treatment, and those receiving end-of-life care. Three patients contracted COVID, with all having mild disease. There were no associations between quality-of-life and/or mood scores and regional COVID surges. Both cancer patients and family caregivers reported good COVID and cancer coping and noted more concern about cancer. Telehealth was widely used and well received. 58% of surveys documented the respondent receiving a recent cancer treatment, but only 5.3% reported knowledge of any COVID-related treatment change. These data contrast with reports from cancer and palliative care clinicians who noted widespread pandemic-related changes in treatment and experienced severe personal anxiety, fatigue, burnout, and moral distress. Conclusions In a large and geographically diverse sample, cancer patients and family caregivers coped well with the pandemic and were generally unaware of pandemic-related cancer care changes. In contrast, cancer and palliative care clinicians reported widespread cancer care delivery changes and significant personal pandemic-related anxiety, fatigue, burnout, and moral distress. Impact Although cancer and palliative care delivery systems sufficiently supported patients and family caregivers during the pandemic with both groups noting good coping, cancer and palliative care clinicians reported significant pandemic-related anxiety, fatigue, burnout, and moral distress. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1479 | End-of-Life Care During COVID-19: A Mixed Methods Analysis of Homebound Patients Cared for via Home-Based Primary and Palliative Care in New York City (RP510) Outcomes 1. Characterize patients in a home-based primary and palliative care (HBMC) practice who died during the spring 2020 COVID-19 surge in New York City 2. Identify multiple levels of disruption that occurred during the COVID-19 surge 3. Describe three ways that home-based medical and palliative care practices are positioned to support end-of-life care for homebound older adults during emergencies Importance COVID-19 end-of-life research has focused primarily on patients who died in hospitals and nursing homes. Less is known about homebound patients receiving home-based primary and palliative care (HBMC) in the community. Objective(s) To describe characteristics and end-of-life care experiences of patients in an HBMC practice who died during New York City's initial 2020 COVID-19 surge. Method(s) Mixed-methods, retrospective quantitative and narrative analysis of demographic, clinical, and end-of-life data from unstructured electronic medical record notes for all patients who died between March 1 and June 30, 2020. Results 112 (9%) of the practice's 1,300 patients died during this period, with the average monthly mortality rate doubling in April 2020, the peak of the NYC surge. Thirty-four (30.4%) had confirmed or probable COVID-19. 58 (52%) were referred to hospice, and 50 enrolled. Eighty-two patients (73%) died at home. Our qualitative analysis found that COVID-19 disrupted regular caregiving routines, often requiring new or inexperienced caregivers to step in; rapidly evolving COVID-19 knowledge and protocols complicated access to services (e.g., requiring patients to present a negative COVID-19 test to begin hospice despite testing shortages); avoiding hospitals and emergency departments became an urgent concern due to visitor restrictions and families’ fears of loved ones dying alone; and COVID-19 complicated ongoing care for complex conditions (e.g., continuing dialysis for COVID+ patients). Throughout the surge, the HBMC team drew on their collaborative practice and longstanding relationships with patients, families, and hospice and home care providers to navigate service disruptions and provide comfort and emotional support. Conclusion(s) Overall, COVID-19 created severe disruptions and barriers to necessary care, further complicating care for this very high-risk, high-needs population. HBMC played an integral role in supporting patients and their families through the pandemic surge. Impact As a model focused on interdisciplinary, whole-person care for medically complex patients, HBMC may be uniquely positioned to support homebound patients at the end of life, both during emergencies and beyond. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1480 | "She Always Knew I Would Call": The Role of Family Liaisons in Serious Illness Communications During the COVID-19 Pandemic (GP719) Outcomes 1. Recognize at least 3 ways in which continuity of care is important in serious illness communication in end-of-life care for patients and families 2. Describe the role of the family liaison in supporting medical teams and patients’ families around end-of-life care communication Importance Due to visitor restrictions across hospitals during the COVID-19 pandemic, many families of critically ill patients could not be physically present with loved ones who were near the end of life (EOL). Clinicians also struggled with relying on telecommunication to deliver prognosis and offer support to grieving families. In an effort to optimize care teams, non–palliative care clinicians became family liaisons to provide phone or video updates to families of patients in the intensive care unit (ICU). Objective(s) To understand the role of family liaisons in end-of-life communication during the COVID-19 pandemic. Method(s) We conducted semistructured audio interviews with 23 clinicians (with additional interviews under way), 7 of whom were redeployed family liaisons, who worked with ICU patients at two U.S. academic hospitals that experienced surges in COVID-19 admissions. Transcripts were analyzed via thematic analysis. Results When patients’ families could not visit in person and were not able to grasp the seriousness of the patients’ rapidly deteriorating conditions, ICU clinicians experienced heightened distress and worried about providing care discordant with patients’ EOL wishes. Additionally, staff shortage and frequent team changes made it difficult for clinicians to provide timely and consistent updates via phone or video. Family liaisons, mostly recruited into the role due to the circumstances of COVID-19, reported that they served as a figure of continuity for families and medical teams and found meaning in their role by establishing trust and rapport with families, providing daily updates, and preparing families for goals-of-care conversations despite language or cultural differences. One ICU clinician reported that liaisons “took the burden and worry away” for teams and families. Conclusion(s) Continuity of care is essential in serious illness communication and may be provided by non–palliative care clinicians to help mitigate challenges during EOL care. Impact Our findings highlight the need for institutional resources to help support the family liaison role. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1481 | Racial Differences in Advance Care Planning and Preferences for End-of-Life Care: Has COVID-19 Changed Anything? (RP312) Outcomes 1. Determine whether the COVID-19 pandemic changed patients’ perceived willingness to talk about advance care planning and preferences for care in the event of severe COVID-19 illness 2. Determine whether the preferences for care changed during COVID-19 for Black and White patients Importance Rates of advance care planning (ACP) are lower and preferences for life-prolong therapies are higher among Black patients than White patients. Objective To examine whether the COVID-19 pandemic, which has disproportionately affected Black patients, has changed racial differences in beliefs about ACP or preferences for end-of-life (EOL) care. Methods We used data from EQUAL ACP, a comparative effectiveness trial of 2 ACP interventions in seriously ill patients ≥65 years old seen in 10 primary care clinics in the South. We asked about COVID-19-related ACP and preferences for care. We used chi-square tests to examine racial differences in responses. Results The sample included 164 Black and 109 White patients. The mean age was 75 years; 63% were female. Similar proportions of Black and White patients (15.9% and 16.8%) reported being “more willing to talk to family/friends/doctors” about wishes for medical care as a result of the pandemic, although most (81.7% and 82.6%) reported “no change in willingness” (p = 0.85). A greater proportion of White than Black patients (26.6% vs. 20.7%) reported talking to family or friends about their wishes for COVID-19-related medical care. There were significant racial differences (p < .001) in EOL care preferences in the event of severe COVID illness. Black patients (36% vs. 12%) were more likely to want all treatments to keep them alive as long as possible, and White patients (75% vs. 55%) were more likely to only want a time-limited trial of life-prolonging measures. Conclusion In this sample, most patients reported that the COVID-19 pandemic has not changed their wiliness to participate in ACP discussions. Black patients were more likely than White patients to want life-prolonging measures in the event of severe COVID illness. Impact Further studies should identify disparities in the quality of palliative care for patients with COVID-19 and determine potential drivers. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1482 | Resilience Training for Hospital Employees in the Era of COVID-19: A Pilot Study of Promoting Resilience in Stress Management (PRISM) at Work (RP413) Outcomes 1. Explain feasibility and acceptability of the PRISM at Work program for healthcare providers 2. Explain the preliminary efficacy of the PRISM at Work program for healthcare providers on reducing stress, resilience, and burnout Importance Healthcare workers face serious mental health challenges as a result of ongoing work stress. The COVID pandemic exacerbated that stress, highlighting the critical need for evidence-based stress interventions. Objective(s) The goal of this study was to examine feasibility, acceptability, and preliminary efficacy of PRISM at Work, a skill-based program designed to reduce stress and build resilience. Method(s) In response to COVID-19, we translated the Promoting Resilience in Stress Management (PRISM) program, a manualized, skill-based program originally developed for adolescents and young adults with medical illness, to a program that could support healthcare workers. It included 6 weekly 1-hour sessions on Zoom, covering topics including stress management, goal setting, cognitive reframing, and meaning making. Feasibility and acceptability were assessed by enrollment and completion rates and satisfaction surveys. Preliminary efficacy was assessed with pre-post assessments of resilience, stress, anxiety, and burnout. Descriptive statistics were used to summarize feasibility and acceptability outcomes. Linear mixed effects regression models were used to examine the impact of PRISM on outcomes. Results Of the 153 participants who enrolled, 92% were female, 46% were ≥40 years old, 87% were White, 53% worked in a clinical role, and 59% were married. Feasibility was demonstrated in that all 15 courses were filled to capacity and 91% completed the program. 91% reported being satisfied with PRISM, and 89% were likely to recommend PRISM to colleagues. Regression analyses demonstrated improvements in resilience (1.74, 95% CI [1.00, 2.47]), anxiety (–2.06, 95% CI [–2.75, –1.36]), stress (–2.43, 95% CI [–3.30, –1.55]), and burnout (–0.37, 95% CI [–0.56, –0.18]) (all ps < .001). Conclusion(s) PRISM at Work is a feasible and acceptable program that shows promise in managing stress, building resilience, and reducing burnout for healthcare workers. Impact A continuation of this work, beyond the scope of the COVID pandemic, is critical given the historical and ongoing burden and distress prevalent in the healthcare profession. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1483 | An Evidence-Informed Cancer Care Communication Tool to Support Patients, Family and Cancer and Palliative Care Clinicians During the COVID-19 Pandemic (RP314) Outcomes 1. Understand the challenges of cancer care communication during the pandemic 2. Learn about a new tool for improving cancer care communication during the pandemic Importance The COVID-19 pandemic transformed the landscape of cancer care. Changes were not always communicated to cancer patients, and it is unknown how it impacted patient decision making. Objective(s) Develop an evidence-informed communication tool to support patients, family, and cancer and palliative care clinicians navigating cancer care during a pandemic. Method(s) Interviews with 71 participants (48 patients, 4 caregivers, 19 clinicians) between August 2020 and July 2021 at four U.S. academic cancer centers. Four focus groups with five professionals representing oncology and palliative care advisory organizations. A 3-hour virtual Stakeholder Summit with 25 attendees representing patients and family, cancer and palliative care clinicians, researchers, and advocacy organizations. Results The initial tool had five domains based on focus group and interview data, reduced to three domains during iterative discussion at the stakeholder summit: COVID-19-related changes and concerns, coping with cancer during the pandemic, and telehealth preferences. Conversations about COVID-19 between patients, caregivers, and clinicians can be emotionally stressful or even taboo in some locales. Stakeholders advised building a tool to facilitate deeper discussions about COVID-19 while allowing patients to opt out and, if preferred, defer pandemic decision making to clinicians. Stakeholders noted that the tool should list only content and preferences that can actually be accommodated by cancer clinicians. Telehealth has different limitations and benefits, which created different preferences for clinicians, patients, and caregivers. Stakeholders agreed that a domain that captured patients’ preferences for its use should be kept. Conclusion(s) A stakeholder-developed and evidence-informed communication tool that outlines pandemic-related changes and existing options for care may help patients and caregivers be more knowledgeable and active in decision making related to their care during the pandemic. Impact A communication tool can illuminate and potentiate patient, family, and clinician discussion about care preferences, even during a pandemic. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1484 | Quality of Life and Depression Symptoms in a Cross-Section of Patients with Advanced Lung Cancer Before and During the COVID-19 Pandemic (RP322) Outcomes 1. Evaluate the effect of the COVID-19 pandemic on quality of life (QOL) and depression symptoms among patients recently diagnosed with lung cancer 2. Apply the results of these analyses to identify patients with newly diagnosed cancer at risk of worse QOL or psychological symptoms during a pandemic or other major crisis in order to allocate supportive care resources Importance Adults with advanced lung cancer commonly experience reduced quality of life (QOL) and psychological symptoms at diagnosis. The COVID-19 pandemic has caused universal distress, but whether it has worsened the experience of patients recently diagnosed with cancer is unclear. Objective(s) This study evaluates associations between the COVID-19 pandemic and QOL and depression among adults with newly diagnosed advanced lung cancer. Method(s) We analyzed baseline data from two randomized controlled trials of early palliative care for patients recently diagnosed with advanced lung cancer (n = 856) to compare QOL and depression among those who enrolled during the COVID-19 pandemic (March 2020 to January 2021) relative to those enrolled prior to the pandemic (March 2018 to January 2019). We used analysis of covariance with the COVID-19 timeframe as the independent variable and QOL (using the Functional Assessment of Cancer Therapy–General score) and depression (using the Patient Health Questionnaire–9 score) as dependent variables, adjusting for age, gender, relationship status, performance status, lung cancer symptoms, and time since diagnosis. We also tested for an interaction between the COVID-19 timeframe and relationship status. IV. Results There was no difference in QOL (adjusted mean difference –1.78; p = 0.137) or depression (0.06; p = 0.889) between patients enrolled before COVID-19 relative to those enrolled during COVID-19 in adjusted analyses. Relationship status moderated the effect of the COVID-19 timeframe on QOL; unmarried patients enrolled during the pandemic experienced significantly worse QOL relative to unmarried patients enrolled pre-pandemic (adjusted mean difference: –5.25; p = 0.011). V. Conclusion(s) The COVID-19 pandemic did not further reduce QOL or increase depression overall for patients recently diagnosed with lung cancer, which suggests that QOL reflects other factors, such as symptoms, that do not vary with this external crisis. Reduced QOL among unmarried patients points to increased supportive care needs. VI. Impact These results emphasize the profound effect of a new diagnosis of cancer on QOL and highlight the need for psychosocial evaluation and supportive care for all patients. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1485 | Did the Quality of ICU End-of-Life Care Suffer During the COVID-19 Pandemic? (GP710) Outcomes 1. Learn the components of the Bereaved Family Survey and what it measures 2. Describe whether there were changes in end-of-life care ratings after the pandemic started Importance Given strained resources and visitation restrictions, families might have perceived lower-quality end-of-life (EOL) care during the COVID-19 pandemic. Objective(s) We compared families’ ratings of EOL care before and during the COVID-19 pandemic. Method(s) Next-of-kin (NOKs) of patients who died in the ICUs of a two-hospital healthcare system between July 2019 and April 2021 were asked to complete a modified Bereaved Family Survey (BFS). We compared care quality reports for patients who died before and during the pandemic using single-item questions and two measures derived from the BFS: Respectful Care and Communication (5 items, alpha = 0.82) and Emotional and Spiritual Support (3 items, alpha = 0.77). Multivariable regression was used to adjust for demographic and clinical characteristics. Results Of 1,029 patients who died in the ICU during the study period, 133 of 388 (34%) NOKs completed the survey before the pandemic and 181 of 639 (28%) during the pandemic. Among those for whom surveys were received, pandemic decedents had higher sequential organ failure assessment score on ICU admission (8.0 vs 6.0, p < 0.01), fewer palliative care consultations (28% vs 40%, p = 0.03), and fewer advance directives (30% vs 44%, p < 0.01) than decedents before the pandemic. In multivariate analysis, NOKs of pandemic decedents more frequently reported that they were notified of impending death (90.6% vs 79.7%, p < 0.01). There was no difference in the global rating of EOL care (63.2% vs 63% rating it as excellent, p = 0.59) or Emotional and Spiritual Support or Respectful Care and Communication factors. Conclusion(s) Despite visitation restrictions, the modified BFS did not detect a difference in families’ overall ratings of quality of EOL care in the ICU among decedents before and during the pandemic. Impact Our study shows that the quality of EOL care can be preserved during periods of stress such as the COVID-19 pandemic. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1486 | "Like Not Having an Arm": Perspectives of Patients, Caregivers and Practitioners on the Impact of Visitor Restrictions on Cancer Care During the COVID-19 Pandemic (RP405) Outcomes 1. Understand how caregiver absence affected the patient and caregiver dyadic relationship 2. Understand how caregiver absence affected cancer and palliative care practitioners Importance Visitor restriction policies to prevent the spread of COVID-19 between patients and practitioners have been widespread during the pandemic, resulting in the exclusion of caregivers at key points of cancer care and treatment decision making. Objective(s) Explore how visitor restrictions impacted cancer treatment decision making and care from patient, caregiver, and practitioner perspectives. Method(s) 71 interviews, including 48 cancer patients, 4 family caregivers, and 19 cancer and palliative care practitioners from four academic cancer centers in the US between August 2020 and July 2021. Results Visitor restrictions that prevented caregivers from participating in clinic appointments and perioperative hospital stays were universally disliked by patients, caregivers, and practitioners. Patients felt deprived of an advocate to help ask questions and to process and retain medical information when patients felt overwhelmed or impaired with “chemo brain.” Caregivers discussed that visitor restrictions made them feel “out of the loop” and increased their anxiety about the patient's care. Cancer practitioners described how visitor restrictions impaired care because caregivers were not present to share valuable health information that the patient may have forgotten or neglected to mention, and clinicians had to spend extra time to call caregivers to relay information. Some surgical oncologists expressed moral distress because they perceived that the absence of caregivers negatively affected their patients’ health outcomes because caregivers were not there to provide emotional support during hospital stays. Conclusion(s) Our data indicate that the structure of the medical decision-making relationship is more tripartite than bilateral, with caregivers being a significant third actor within the medical decision-making process. Caregivers provided support in the decision-making and care process to both patients and practitioners, and their absence created additional burden on both. Impact As the pandemic continues into its second year with new surges and a return to visitor restrictions, health systems should reconsider visitor policies to ease the emotional and physical burden on patients, caregivers, and practitioners. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1487 | "I Depend on Her for Everything": Characterizing the Role of Home Care Workers Caring for Seriously Ill Homebound Older Adults During the COVID-19 Pandemic Through a Mixed-Methods Study (RP419) Outcomes 1. Illustrate the role of home care workers (HCWs) in caring for homebound older adults during COVID-19 2. Characterize disruptions in HCW services in the setting of COVID-19 and how these impacted the ability of patients to stay safely at home 3. Identify the impact of HCW services on patients and their family and other unpaid caregivers Importance The devastating impact of the COVID-19 pandemic has made the need for quality home-based care for homebound older adults with serious illness clear. Home care workers (HCWs) played a critical role in keeping homebound older adults safely at home during COVID-19, yet their essential work is often undervalued and understudied. Objective(s) To illustrate the roles of HCWs during COVID-19 and how HCW service disruptions impacted patients and their caregivers. Method(s) We collected demographic and clinical data and performed a thematic analysis of medical records from 53 patients with HCWs in a home-based primary and palliative care practice in New York City. We abstracted unstructured clinical notes between 12/1/2019 and 12/31/2020 into a priori and emergent categories and identified core themes via discussion in team meetings. Results Of the 53 patients, 24.5% died during the initial COVID surge, 34% lived alone, and 41.5% had 24-hour HCWs. The following five themes emerged: Changes to HCW roles included taking on new medical tasks and increased intensity of existing tasks (e.g., managing progressing dementia behaviors); delays in staffing contributed to changes in HCW hours and continuity, including unexpected loss of services; disruptions in HCW services put patients at risk of hospitalization and nursing home placement due to safety concerns; payment structure and patient preferences made it challenging to get sufficient hours of paid care; and lack of adequate and high-quality HCW services created additional caregiver responsibilities and caregiver burden. Conclusion(s) During COVID-19, HCWs were essential to keeping homebound older adults safely at home. Inadequate HCW services, including unstable schedules and inadequate hours of paid care, became particularly disruptive, leading to risk of hospitalization and prolonged length of stay. Impact This analysis can inform policies encouraging better integration of HCWs on medical teams and addressing workforce shortages to expand access to adequate HCW services for homebound older adults and their caregivers to manage serious illness and end-of-life care. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1488 | Rationalizing Emotions: A Secondary Analysis of the Supportive and Palliative Cancer Care Clinicians' Experiences During COVID-19 (GP766) Outcomes 1. Recall two emotions that oncology clinicians experienced during COVID-19 2. Recognize one pattern of mixed emotions experienced by clinicians during COVID-19 Background The COVID-19 pandemic has called for a radical change in the delivery of oncology and palliative care services. In the first phase of the pandemic, oncology care was disrupted, with delayed screening and postponement of life-saving treatments including chemotherapy, radiation, and surgeries. Psycho-oncology care shifted due to social isolation, visitor restrictions, fear of infection, and transitions to telehealth. Emerging research is examining these effects on the patient and family unit; however, there is limited research exploring the emotional impact on cancer and palliative care clinicians. We know that healthcare professionals worldwide are experiencing immense strain, depression, anxiety, PTSD, and burnout, and many are considering leaving their profession. Understanding the emotional experience of clinicians in the early phase of the pandemic is key to addressing these issues. Methods Through a secondary analysis of qualitative data collected in the Virtual Supportive Cancer Care Research study, clinician interview transcripts were analyzed using an interpretive descriptive approach. Clinician participants represented various supportive and palliative roles in oncology care, including the disciplinary perspectives of nurse practitioners, social workers, dieticians, nurses, and physicians. Findings Clinicians experienced a plethora of emotions. These emotions were experienced on four axes: overt or latent; independent, sequential, or simultaneous; mixed emotions, which were experienced in three main patterns (contradictory, interwoven, and rationalizing); and internalized or externalized. All emotions could exist on multiple axes and ultimately guided clinicians’ reactions, responses, and reflections on their emotions as well as their behaviors. Conclusion Undoubtedly, clinicians have been significantly impacted both physically and emotionally during the pandemic. We are now faced with a unique opportunity to support clinicians holistically, as we do with patients. This study is a first step in unpacking what is behind clinician emotions and processing patterns in extreme care contexts such as the COVID-19 pandemic. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1489 | The Ever-Changing Present & Uncertain Future: Clinician Distress During the COVID-19 Pandemic: A Dimensional Analysis (GP754) Outcomes 1. Illustrate the dimensions of clinician distress by narratively describing the phenomenon in caring for patients with COVID-19 2. Describe the clinical, research, and ethical implications of clinician distress on patients, families, and clinicians Importance During the COVID-19 pandemic, healthcare clinicians have experienced unprecedented physical and psychological distress. Many expressed emotions in the social media, yet little research has been conducted on the emotional experience of these clinicians. Objective We aimed to understand the range of emotions expressed by clinicians through various media outlets. Methods A qualitative dimensional analysis was used with the goal of breaking down the concept of clinician distress into its smallest parts, including “attributes, interconnections, context, process, and implications” and then reconstructing the concept with a new and clearer understanding. Search strategy centered around data written in the clinician's voice through published editorials, commentaries, and opinion pieces from January 1, 2020 through July 22, 2020. Total records of the combined searches resulted in 545 editorials; after deduplication and full text review, 10 journal editorials and 24 newspaper editorials were included in analysis. Results A narrative of clinician distress during the COVID-19 pandemic among American clinicians emerged, grounded by the perspective of a clinician's perceptions of clinical care in the context of an ever-changing present and uncertain future, where a clinician recognizes within themselves one of the following conditions: an emotional response or a conflict in tandem with a significant role change resulting in a process of the inability to feel and act according to one's values due to the COVID-19 pandemic, leading to the ultimate consequence of clinician distress. Impact This study adds to the concept of clinician distress: expanding the understanding of clinician distress during a global pandemic through published work written by clinicians themselves, including the emotional aspects of caring for patients, developing a new framework for understanding clinician distress by analyzing clinicians’ own written words, and exploring real-time distress through a novel qualitative method to better understand the clinicians’ experiences. | J Pain Symptom Manage | 2022 | CORD-19 | |
| 1490 | FMPM Best Paper Award 2021 | Financ Mark Portf Mang | 2022 | CORD-19 | |
| 1491 | En temps d'épidémie et de vie ordinaire: le monde de la vieillesse dans l'œuvre d'Albert Camus En réponse à l’absurdité du monde, Albert Camus a souhaité que la révolte n’enferme pas les êtres humains dans la passivité mais les porte à agir pour défendre la liberté, la justice et pour soulager les souffrances. Camus a souhaité ainsi illustrer dans ses œuvres une éthique de la compréhension. Le roman La Peste raconte une épidémie s’abattant sur une ville et qui décime toutes les générations. Qu’en fut-il alors de la place des personnes âgées dans ce drame ? L’expérience de la pandémie à SARS-CoV-2 qui, elle, a frappé électivement les personnes âgées incitait à explorer cette question qui, au-delà de la pandémie, questionne sur la vision d’une société sur les personnes âgées et sur les relations intergénérationnelles. Il était alors tentant de parcourir l’ensemble de l’œuvre de Camus pour s’interroger sur le regard qu’il portait sur les vieux, lui, révolté contre un monde absurde mais soucieux de résister, lui qui faisait dire au Docteur Rieux, parcourant la ville pour visiter ses malades, qu’un monde sans amour était comme un monde mort. Le regard que porte Camus sur les vieux et les vieilles mérite d’être médité dans le monde d’aujourd’hui. In reaction to the absurdity of the world, Albert Camus hoped that revolt would not imprison human beings in passivity but would lead them to act in defence of freedom, justice and the relief of suffering. Camus thus aimed in his writings to set out “an ethic of understanding”. His novel The Plague tells of an epidemic that strikes a city and decimates all generations. What was the place of the elderly in this catastrophe? The experience of the SARS-CoV-2 pandemic, which mainly affected the elderly, prompted us to explore this issue, which, beyond the pandemic, raises questions about a society's view of the elderly and about intergenerational relationships. It was then tempting to peruse the whole of Camus's writings and to explore the way he viewed the elderly - he who rose up against an absurd world but was intent on resisting it, he who had Doctor Rieux, visiting his patients across the city, say that a world without love was like a dead world. Camus’ view of old people deserves to be pondered in today's world. | N/A | 2022 | CORD-19 | |
| 1492 | The emergence of SARS-CoV-2 variants of concern in Australia by haplotype coalescence reveals a continental link to COVID-19 seasonality SARS-CoV-2 continues to evolve, even after implementation of public-wide vaccination, as can be observed by an increasing number of mutations over time. Compared to responses by the United States and European countries, the disease mitigation strategies employed by the Australian government have been swift and effective. This provides a unique opportunity to study the emergence of variants of concern (VOCs) at many latitude levels in a country that has been able to control infection for the majority of the pandemic. In the present study, we explored the occurrence and accumulation of major mutations typical of VOCs in different regions of Australia and the effects that latitude has on the establishment of VOC-induced disease. We also studied the constellation of mutations characteristic of VOCs to determine if the mutation sets acted as haplotypes. Our goal was to explore processes behind the emergence of VOCs as the viral disease progresses towards becoming endemic. Most reported COVID-19 cases were in largest cities located within a –30°S to −50°S latitude corridor previously identified to be associated with seasonal behavior. Accumulation plots of individual amino acid variants of major VOCs showed that the first major haplotypes reported worldwide were also present in Australia. A classification of accumulation plots revealed the existence of 18 additional haplotypes associated with VOCs alpha, delta and omicron. Core mutant constellations for these VOCs and curve overlaps for variants in each set of haplotypes demonstrated significant decoupling patterns, suggesting processes of emergence. Finally, construction of a “haplotype network” that describes the viral population landscape of Australia throughout the COVID-19 pandemic revealed significant and unanticipated seasonal patterns of emergence and diversification. These results provide a unique window into our evolutionary understanding of a human pathogen of great significance. They may guide future research into mitigation and prediction strategies for future VOCs. | N/A | 2022 | CORD-19 | |
| 1493 | Inferior Liver Transplant Outcomes during early COVID-19 pandemic in United States Background : Since its declaration as a global pandemic on March11th 2020, COVID-19 has had a significant effect on solid-organ transplantation. Aim of this study was to analyze the impact of COVID-19 on Liver transplantation (LT) in United States. Methods : We retrospectively analyzed the United Network for Organ Sharing database regarding characteristics of donors, adult-LT recipients, and transplant outcomes during early-COVID period (March 11- September 11, 2020) and compared them to pre-COVID period (March 11 - September 11, 2019). Results : Overall, 4% fewer LTs were performed during early-COVID period (4107 vs 4277). Compared to pre-COVID period, transplants performed in early-COVID period were associated with: increase in alcoholic liver disease as most common primary diagnosis (1315 vs 1187, P< 0.01), higher MELD score in the recipients (25 vs 23, P<0.01), lower time on wait-list (52 vs 84 days, P<0.01), higher need for hemodialysis at transplant (9.4 vs 11.1%, P=0.012), longer distance from recipient hospital (131 vs 64 miles, P<0.01) and higher donor risk index (1.65 vs 1.55, P<0.01). Early-COVID period saw increase in rejection episodes before discharge (4.6 vs 3.4%, P=0.023) and lower 90-day graft/patient survival (92.2 vs 96.5 %, P<0.01; 90.2 vs 95.1 %, P<0.01). In multivariable cox-regression analysis, early-COVID period was the independent risk factor for graft failure at 90-days post-transplant (HR 1.77, P<0.01). Conclusions : During early-COVID period in United States, overall LT decreased, alcoholic liver disease was primary diagnosis for LT, rate of rejection episodes before discharge was higher and 90-days post-transplant graft survival was lower. | N/A | 2022 | CORD-19 | |
| 1494 | Board gender diversity and responsible banking during the COVID-19 pandemic This study investigates whether board gender diversity matters in banks' initial responses to the COVID-19 pandemic in supporting their customers, communities and governments. We construct a unique and comprehensive COVID-19 Bank Response Measure (C19BRM) by compiling a novel hand-collected dataset on supportive measures announced by US and European banks during the first wave of the pandemic. We find that banks with higher board representation of women directors supported their customers and communities more. Our findings also reveal that more women on the boards increased their charity and donations. Our results are robust to the potential self-selection bias of women choosing to join boards of more responsible banks, the omitted variables bias, and alternative measures of gender diversity. | N/A | 2022 | CORD-19 | |
| 1495 | The Negative Impact of Social Media during COVID-19 Pandemic The coronavirus pandemic is a global pandemic of Coronavirus Disease 2019 (COVID-19) resulting from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2). Despite its numerous benefits for sharing health information, social media has raised several concerns in terms of posing panic among the general population around the world during the COVID-19 pandemic. The main objective of this study was to investigate the negative impact of social media during the COVID-19 outbreak. A web-based poll was used to collect data from social media users. Snowball sampling was used to acquire information from participants for 1 month, from September 1 to September 30, 2020. To examine the effect of social media on fear among participants, the study employed Cohen’s d statistic, analysis of variance, Chi-squared test, and linear regression analysis. The study results showed that more than three-fourth (73.26%) used Facebook followed by Telegram by 14.49%. Health news was the most frequently seen, read, or heard with 88.20% of the total. Moreover, 86.73% of respondents experienced panic, while only 13.27% was not. Compared to males, females were more likely to follow health news (p < 0.001). The majority of participants reported being psychologically affected, while only a few were physically affected. Females were substantially more affected mentally and reported significantly more fear than males (p < 0.001). The effect of social media panic is associated with participants’ age, and gender at a 5% level of significance. A significant positive link between social media and the diffusion of COVID-19 fear has been shown in this study. According to the result of regression analysis, social media usage has a significant effect on the spread of panic among participants at a 5% level of significance. Study revealed that social media use has a significant impact on the development of panic among people regarding the COVID-19 epidemic, with possibly detrimental psychological and mental health repercussions.This study also discovered a strong correlation between COVID-19 fear and social media. According to the findings, the impact of social media on respondents’ terror levels differs depending on their age and gender. The government should take steps to punish those who spread false information or fake news to the public. | N/A | 2022 | CORD-19 | |
| 1496 | Call for Papers: Neurology and the COVID-19 emergency | Brain Hemorrhages | 2022 | CORD-19 | |
| 1497 | Immunosenescence, Immune Fitness and Vaccination Schedule in the Adult Respiratory Patient Immunosenescence is the gradual deterioration of the immune system caused by advancing age. It is associated with a reduced ability to respond to infections and develop long-term immune memory. It plays a key role in the development of respiratory diseases that are more common in older people, such as asthma, COPD, diffuse interstitial disease and respiratory infections in the elderly. We call immune fitness the establishment of lifestyle habits that can improve our immune capacity. We now know that good eating habits, good social relationships, not smoking, limiting alcohol consumption, exercising, controlling stress levels and establishing a proper vaccination programme can slow down the process of immunosenescence. Influenza and pneumococcal vaccines (PCV13 and PPSV23 conjugate) are well established in the adult vaccination schedule. The new pneumococcal vaccines PCV15 and PCV20 will help to extend protection against pneumococcal disease in adults. The vaccine against COVID-19 is currently the most useful tool to prevent the disease and reduce its pathogenicity. COPD patients and others with respiratory diseases may benefit from prevention of herpes zoster and Bordetella pertussis through vaccination. RSV vaccine may be another vaccine to be added to the schedule, pending the results of its studies. | N/A | 2022 | CORD-19 | |
| 1498 | INTERVENTIONAL PULMONOLOGY AND ISSUES RELATED TO THE LUNG SURGERY | Lung India | 2022 | CORD-19 | |
| 1499 | INTERVENTIONAL PULMONOLOGY AND ISSUES RELATED TO THE LUNG SURGERY | Lung India | 2022 | CORD-19 | |
| 1500 | ALLERGY AND AIRWAY DISEASES | Lung India | 2022 | CORD-19 |
(1) COVID-19 Open Research Dataset (CORD-19). 2020. Version 2022-06-02. Retrieved from https://ai2-semanticscholar-cord-19.s3-us-west-2.amazonaws.com/historical_releases.html. Accessed 2022-06-05. doi:10.5281/zenodo.3715506
(2) Chen Q, Allot A, & Lu Z. (2020) Keep up with the latest coronavirus research, Nature 579:193 and Chen Q, Allot A, Lu Z. LitCovid: an open database of COVID-19 literature. Nucleic Acids Research. 2020. (version 2023-01-10)
(3) Currently tweets of June 23rd to June 29th 2022 have been considered.