| Title | Venue | Year | Impact | Source |
| 951 | Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management Abstract Human coronavirus-associated myocarditis is known, and a number of COVID-19-related myocarditis cases have been reported. The pathophysiology of COVID-19-related myocarditis is thought to be a combination of direct viral injury and cardiac damage due to the host’s immune response. COVID-19 myocarditis diagnosis should be guided by insights from previous coronavirus and other myocarditis experience. The clinical findings include changes in ECG, cardiac biomarkers, and impaired cardiac function. When cardiac MRI is infeasible, cardiac CT angiography with delayed myocardial imaging may serve to exclude significant coronary artery disease and identify myocardial inflammatory patterns. Because many COVID-19 patients have cardiovascular comorbidities, myocardial infarction should be considered. Where the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. Arrhythmias are not uncommon in the COVID-19 patients; however, its pathophysiology is still speculative. Nevertheless, clinicians should be vigilant to provide prompt monitoring and treatments. The long-term impact of COVID-19 myocarditis, including in the majority of mild cases remains unknown. | Heart Rhythm | 2020 | | LitCov and CORD-19 |
| 952 | The effect of large-scale anti-contagion policies on the COVID-19 pandemic N/A | Nature | 2020 | | LitCov and CORD-19 |
| 953 | A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells Summary The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site containing multiple arginine residues (multibasic) not found in closely related animal coronaviruses. However, the role of this multibasic cleavage site in SARS-CoV-2 infection is unknown. Here, we report that the cellular protease furin cleaves the spike protein at the S1/S2 site and that cleavage is essential for S-protein-mediated cell-cell fusion and entry into human lung cells. Moreover, optimizing the S1/S2 site increased cell-cell, but not virus-cell, fusion, suggesting that the corresponding viral variants might exhibit increased cell-cell spread and potentially altered virulence. Our results suggest that acquisition of a S1/S2 multibasic cleavage site was essential for SARS-CoV-2 infection of humans and identify furin as a potential target for therapeutic intervention. | Mol Cell | 2020 | | LitCov and CORD-19 |
| 954 | A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health system capacity, and deficit of personal protective equipment (PPE). Although in most cases the symptoms are mild or absent, SARS-CoV-2 infection can lead to serious acute respiratory disease and multisystem failure. The research community responded to this new disease with a high level of transparency and data sharing; with the aim to better understand the origin, pathophysiology, epidemiology and clinical manifestations. The ultimate goal of this research is to develop vaccines for prevention, mitigation strategies, as well as potential therapeutics. The aim of this review is to summarize current knowledge regarding the novel SARS CoV-2, including its pathophysiology and epidemiology, as well as, what is known about the potential impact of COVID-19 on reproduction, fertility care, pregnancy and neonatal outcome. This summary also evaluates the effects of this pandemic on reproductive care and research, from Canadian perspective, and discusses future implications. In summary, reported data on pregnant women is limited, suggesting that COVID-19 symptoms and severity of the disease during pregnancy are similar to those in non-pregnant women, with pregnancy outcomes closely related to severity of maternal disease. Evidence of SARS-CoV-2 effects on gametes is limited. Human reproduction societies have issued guidelines for practice during COVID-19 pandemic that include implementation of mitigation practices and infection control protocols in fertility care units. In Canada, imposed restrictions at the beginning of the pandemic were successful in containing spread of the infection, allowing for eventual resumption of assisted reproductive treatments under new guidelines for practice. Canada dedicated funds to support COVID-19 research including a surveillance study to monitor outcomes of COVID-19 during pregnancy and assisted reproduction. Continuous evaluation of new evidence must be in place to carefully adjust recommendations on patient management during assisted reproductive technologies (ART) and in pregnancy. | J Ovarian Res | 2020 | | LitCov and CORD-19 |
| 955 | A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. The entry point for the virus is ACE2, which is a component of the counteracting hypotensive axis of RAS. Bradykinin is a potent part of the vasopressor system that induces hypotension and vasodilation and is degraded by ACE and enhanced by the angiotensin(1-9) produced by ACE2. Here, we perform a new analysis on gene expression data from cells in bronchoalveolar lavage fluid (BALF) from COVID-19 patients that were used to sequence the virus. Comparison with BALF from controls identifies a critical imbalance in RAS represented by decreased expression of ACE in combination with increases in ACE2, renin, angiotensin, key RAS receptors, kinogen and many kallikrein enzymes that activate it, and both bradykinin receptors. This very atypical pattern of the RAS is predicted to elevate bradykinin levels in multiple tissues and systems that will likely cause increases in vascular dilation, vascular permeability and hypotension. These bradykinin-driven outcomes explain many of the symptoms being observed in COVID-19. | Elife | 2020 | | LitCov and CORD-19 |
| 956 | Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection N/A | Nat Med | 2021 | | LitCov and CORD-19 |
| 957 | Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). The CoV spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Here, we identified the receptor-binding domain (RBD) in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and, hence, attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells, thus inhibiting their infection to host cells. SARS-CoV RBD-specific antibodies could cross-react with SARS-CoV-2 RBD protein, and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2, suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Cell Mol Immunol | 2020 | | LitCov and CORD-19 |
| 958 | Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe N/A | Nature | 2020 | | LitCov and CORD-19 |
| 959 | Mental health problems and social media exposure during COVID-19 outbreak Huge citizens expose to social media during a novel coronavirus disease (COVID-19) outbroke in Wuhan, China. We assess the prevalence of mental health problems and examine their association with social media exposure. A cross-sectional study among Chinese citizens aged≥18 years old was conducted during Jan 31 to Feb 2, 2020. Online survey was used to do rapid assessment. Total of 4872 participants from 31 provinces and autonomous regions were involved in the current study. Besides demographics and social media exposure (SME), depression was assessed by The Chinese version of WHO-Five Well-Being Index (WHO-5) and anxiety was assessed by Chinese version of generalized anxiety disorder scale (GAD-7). multivariable logistic regressions were used to identify associations between social media exposure with mental health problems after controlling for covariates. The prevalence of depression, anxiety and combination of depression and anxiety (CDA) was 48.3% (95%CI: 46.9%-49.7%), 22.6% (95%CI: 21.4%-23.8%) and 19.4% (95%CI: 18.3%-20.6%) during COVID-19 outbroke in Wuhan, China. More than 80% (95%CI:80.9%-83.1%) of participants reported frequently exposed to social media. After controlling for covariates, frequently SME was positively associated with high odds of anxiety (OR = 1.72, 95%CI: 1.31–2.26) and CDA (OR = 1.91, 95%CI: 1.52–2.41) compared with less SME. Our findings show there are high prevalence of mental health problems, which positively associated with frequently SME during the COVID-19 outbreak. These findings implicated the government need pay more attention to mental health problems, especially depression and anxiety among general population and combating with “infodemic” while combating during public health emergency. | PLoS One | 2020 | | LitCov and CORD-19 |
| 960 | Online learning during COVID-19 produced equivalent or better student course performance as compared with pre-pandemic: empirical evidence from a school-wide comparative study BACKGROUND: The COVID-19 pandemic forced dental schools to close their campuses and move didactic instruction online. The abrupt transition to online learning, however, has raised several issues that have not been resolved. While several studies have investigated dental students’ attitude towards online learning during the pandemic, mixed results have been reported. Additionally, little research has been conducted to identify and understand factors, especially pedagogical factors, that impacted students’ acceptance of online learning during campus closure. Furthermore, how online learning during the pandemic impacted students’ learning performance has not been empirically investigated. In March 2020, the dental school studied here moved didactic instruction online in response to government issued stay-at-home orders. This first-of-its-kind comparative study examined students’ perceived effectiveness of online courses during summer quarter 2020, explored pedagogical factors impacting their acceptance of online courses, and empirically evaluated the impact of online learning on students’ course performance, during the pandemic. METHOD: The study employed a quasi-experimental design. Participants were 482 pre-doctoral students in a U.S dental school. Students’ perceived effectiveness of online courses during the pandemic was assessed with a survey. Students’ course grades for online courses during summer quarter 2020 were compared with that of a control group who received face-to-face instruction for the same courses before the pandemic in summer quarter 2019. RESULTS: Survey results revealed that most online courses were well accepted by the students, and 80 % of them wanted to continue with some online instruction post pandemic. Regression analyses revealed that students’ perceived engagement with faculty and classmates predicted their perceived effectiveness of the online course. More notably, Chi Square tests demonstrated that in 16 out of the 17 courses compared, the online cohort during summer quarter 2020 was equally or more likely to get an A course grade than the analogous face-to-face cohort during summer quarter 2019. CONCLUSIONS: This is the first empirical study in dental education to demonstrate that online courses during the pandemic could achieve equivalent or better student course performance than the same pre-pandemic in-person courses. The findings fill in gaps in literature and may inform online learning design moving forward. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12909-021-02909-z. | BMC Med Educ | 2021 | | LitCov and CORD-19 |
| 961 | Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis BACKGROUND: The COVID-19 pandemic has had a significant impact on public mental health. Therefore, monitoring and oversight of the population mental health during crises such as a panedmic is an immediate priority. The aim of this study is to analyze the existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic. METHOD: In this systematic review and meta-analysis, articles that have focused on stress and anxiety prevalence among the general population during the COVID-19 pandemic were searched in the Science Direct, Embase, Scopus, PubMed, Web of Science (ISI) and Google Scholar databases, without a lower time limit and until May 2020. In order to perform a meta-analysis of the collected studies, the random effects model was used, and the heterogeneity of studies was investigated using the I(2) index. Moreover. data analysis was conducted using the Comprehensive Meta-Analysis (CMA) software. RESULTS: The prevalence of stress in 5 studies with a total sample size of 9074 is obtained as 29.6% (95% confidence limit: 24.3–35.4), the prevalence of anxiety in 17 studies with a sample size of 63,439 as 31.9% (95% confidence interval: 27.5–36.7), and the prevalence of depression in 14 studies with a sample size of 44,531 people as 33.7% (95% confidence interval: 27.5–40.6). CONCLUSION: COVID-19 not only causes physical health concerns but also results in a number of psychological disorders. The spread of the new coronavirus can impact the mental health of people in different communities. Thus, it is essential to preserve the mental health of individuals and to develop psychological interventions that can improve the mental health of vulnerable groups during the COVID-19 pandemic. | Global Health | 2020 | | LitCov and CORD-19 |
| 962 | Chloroquine is a potent inhibitor of SARS coronavirus infection and spread BACKGROUND: Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available. RESULTS: We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations. CONCLUSION: Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds. | Virol J | 2005 | | CORD-19 |
| 963 | Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR BACKGROUND: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. AIM: We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. METHODS: Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. RESULTS: The workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive – Global (EVAg), a European Union infrastructure project. CONCLUSION: The present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks. | Euro Surveill | 2020 | | LitCov and CORD-19 |
| 964 | COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines N/A | Eur Rev Med Pharmacol Sci | 2021 | | LitCov and CORD-19 |
| 965 | Learning losses and educational inequalities in Europe: Mapping the potential consequences of the COVID-19 crisis It is widely discussed that the pandemic has impacted educational inequalities across the world. However, in contrast to data on health or unemployment, data on education outcomes are not timely. Hence, we have extremely limited knowledge about pandemic-related learning losses at the national and cross-national levels. As it might take years to get suitable comparative data, this study uses the latest large-scale international achievement survey from before the pandemic, the Trends in International Mathematics and Science Study 2019, to answer two research questions. First, which European countries are most likely to have experienced higher learning loss among their children? Second, which European countries have most likely experienced the greatest increases in learning inequalities? Results based on 4th graders’ school achievements indicate that educational inequalities between and within countries are likely to have augmented substantially throughout Europe. Some European countries are probably already facing an education crisis. | J Eur Soc Policy | 2022 | | CORD-19 |
| 966 | Children's Experiences of Death Anxiety and Responses to the Covid-19 Pandemic The aim of this study was to explore children's experience and responses to the Covid-19 pandemic through their illustrations and short narrations. During October 2020 and January 2021 data was collected from thirteen children aged 9–10 years old in a primary school in the North-West of England. Children were asked to draw their thoughts and feelings about the pandemic and to write a short narration to accompany the drawing. Thematic analysis of data revealed that during the pandemic children at this age have an understanding of death, experience death anxiety and are able to use creative expression to facilitate meaning of the impact of lockdown on their lives such as feeling isolated, lonely, sad and bored. Creative expression also facilitated adaptive coping mechanisms derived from being able to spend more time with family. The data on primary school children is part of a larger study which involved surveys and interviews with children aged 12–16 years in secondary schools. | Illn Crises Loss | 2022 | | CORD-19 |
| 967 | Dream Recall Frequency, Lucid Dream Frequency and Personality During the Covid-19 Pandemic Dream recall frequency and lucid dream frequency showed large inter-individual differences that are partly related to personality dimensions. However, as dream research is a small field, independent studies are necessary to build a solid empirical foundation. The present online survey included 1,537 participants (1150 women, 387 men) with a mean age of 35.1 ± 15.8 years. Whereas the relationship between openness to experience and dream recall frequency was in line with previous research – supporting the life-style hypothesis of dream recall, the associations between the Big Five personality factors and lucid dream frequency are less homogenous; for example, the negative relationship between neuroticism and lucid dream frequency. Even though the effect sizes of these associations are small, the findings can help in identifying links between waking and dreaming. Moreover, it was found that lucid dream frequency was related to Covid-19-related worries, whereas dream recall frequency was not. | Imagin Cogn Pers | 2022 | | CORD-19 |
| 968 | Intensive care clincians' information acquisition during the first wave of the Covid 19 pandemic INTRODUCTION: The global pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has led to an unprecedented demand on critical care resources. The United Kingdom experienced its ‘first wave’ of Coronavirus–19 (Covid-19) disease in Spring 2020. Critical care units had to make major changes to their working practices in a short space of time and faced multiple challenges in doing so, including the challenge of caring for patients in multiple organ failure secondary to Covid-19 infection in the absence of an established evidence base of best practice. We undertook a qualitative investigation of the personal and professional challenges faced by critical care consultants in one Scottish health board in acquiring and evaluating information to guide clinical decision making during the first wave of the SARS-CoV-2 pandemic. METHODS: Critical care consultants in NHS Lothian working in critical care from March to May 2020 were eligible to participate in the study. Participants were invited to take part in a one-to-one semi structured interview conducted using Microsoft Teams videoconferencing software. Reflexive thematic analysis was used as the method for data analysis using qualitative research methodology informed by a subtle realist position. RESULTS: Analysis of the interview data generated the following themes: The Knowledge Gap; Trust in Information; and Implications for Practice. Illustrative quotes are presented in the text and thematic tables. DISCUSSION: This study explored the experiences of critical care consultant physicians in acquiring and evaluating information to guide clinical decision making during the first wave of the SARS CoV2 pandemic. This study revealed that clinicians were profoundly affected by the pandemic and the ways in which it changed how they could access information to guide clinical decision making. The paucity of reliable information on SARS-CoV-2 posed a significant threat to the clinical confidence of participants. Two strategies were adopted to ease mounting pressures – an organised approach to data collection and the establishment of a local community of collaborative decision-making. These findings contribute to the wider literature by describing health care professionals’ experiences in unprecedented times and could inform recommendations for future clinical practice. This could include governance around responsible information sharing in professional instant messaging groups, and medical journal guidelines on suspension of usual peer review and other quality assurance processes during pandemics. | J Intensive Care Soc | 2022 | | CORD-19 |
| 969 | COVID-19 attributed Changes of Home and Family Responsibilities among Single Mothers Lockdown measures during COVID-19 have presented increased challenges in the home and family responsibilities. Single mothers may face unique challenges as they may be isolated from external family supports. Changes on a 19-item home and family work role survey pre- and post-COVID were tested with a paired t-test and sign test; the impact of age and people in the home was assessed using linear regression. There was a significant increase (p < 0.05) in 6/19 post-COVID-19 family responsibilities. In comparison to pre-COVID-19, post-COVID-19 single mothers reported a statistically significant median increase in family responsibilities (Mdn = .0000), p < .041. Each additional person living in the home was associated with a decrease in family responsibilities (B = -13.1, 95% CI [-21.943, -4.247]). Changes in the home and family responsibilities confirm that COVID-19 led to increased unpaid work to fulfill home and family responsibilities among single mothers. | J Fam Issues | 2022 | | CORD-19 |
| 970 | Development of Ethical COVID-19 Antibody Testing that Adheres to Pro-Life Principles The use of cell lines derived from elective abortions in the development and production of COVID vaccines was opposed by the Catholic church who encouraged pharmaceutical companies and governmental health agencies to produce and distribute ethical vaccines that do not create problems of conscience for healthcare providers or those requiring vaccination. In response to the church’s call for ethical alternatives in research and development of COVID vaccines, we present an approach for the measurement of Anti–SARS-CoV-2 Ig antibodies in blood plasma (COVID-19 Antibody test) that does not utilize any products produced in aborted fetal cell lines. The SARS-CoV-2 RBD protein used in this test was produced in Chinese Hamster Ovary (CHO) cells and test performance for determination of SARS-CoV-2 seroconversion was equivalent to a commercially available COVID-19 antibody test that utilized RBD protein and other reagents produced in embryonic cell lines. | Linacre Q | 2022 | | CORD-19 |
| 971 | Oral Presentations | Global Spine J | 2022 | | CORD-19 |
| 972 | Optimal location and operation of waste-to-energy plants when future waste composition is uncertain In many countries, waste management is increasingly geared towards a circular economy, aiming for a sustainable society with less waste generation, fewer landfills, and a higher rate of recycling. Waste-to-Energy (WtE) plants, which convert waste into heat and energy, can contribute to the circular economy by utilizing types of waste that cannot be recycled. Due to the varying quality of sorting and socio-economic conditions in individual regions, the waste composition differs between regions and has an uncertain future development. Waste composition significantly affects the operation of WtE plants due to differences in energy potential. This paper supports strategic capacity planning for waste energy recovery by introducing a two-stage stochastic mixed-integer linear programming model that captures waste composition uncertainty through scenarios of possible future development. The results of the model provide insights into the economics of operation and identify important factors in the sustainability of the waste handling system. The model is demonstrated on an instance with six scenarios for waste management in the Czech Republic for the year 2030. The solution of the proposed model is to build 14 new WtE plants with a total capacity of 1970 kt in addition to the four existing plants with a capacity of 831 kt. The annual energy recovery capacity is expected to increase almost four times to satisfy EU directives that restrict waste landfilling. | N/A | 2022 | | CORD-19 |
| 973 | Better Care Through Hypofractionation | J Med Imaging Radiat Sci | 2022 | | CORD-19 |
| 974 | The COVID-19 pandemic uncertainty, investor sentiment and global equity markets: Evidence from the time-frequency co-movements We use daily data of the Google search engine volume index (GSVI) to capture the pandemic uncertainty and examine its effect on stock market activity (return, volatility, and illiquidity) of major world economies while controlling the effect of the Financial and Economic Attitudes Revealed by Search (FEARS) sentiment index. We use a time-frequency based wavelet approach comprising wavelet coherence and phase difference for our empirical assessment. During the early spread of the COVID-19, our results suggest that pandemic uncertainty, and FEARS sentiment strongly co-move, and increased pandemic uncertainty leads to pessimistic investor sentiment. Furthermore, our partial wavelet analysis results indicate a synchronization relationship between pandemic uncertainty and stock market activities across G7 countries and the world market. Our results are robust to the inclusion of alternative pandemic fear measure in the form of equity market volatility infectious disease tracker. The pandemic uncertainty and associated sentiment implications could be one plausible reason for increased volatility and illiquidity in the market, and hence, policymakers should look upon this issue for the financial market stability perspective. | N/A | 2022 | | CORD-19 |
| 975 | Analysis of the role of PMCT during the COVID-19 pandemic: A systematic review Objectives : During COVID-19 pandemic PMCT has been proposed as a forensic investigation method. This systematic review is aimed to systematize evidence and peer-reviewed opinions reported during the first two years of pandemic, to evaluate the role of PMCT during the COVID-19 pandemic. Materials and methods : An online literature search was performed to identify publications on PMCT during the COVID-19 pandemic between December 2019 and March 2022. For each publication included, the following data were collected: title and abstract, year of publication, type of article, number and type of individuals examined. The selected publications were also categorized based on PMCT findings, histopathological results, the comparison between PMCT and histopathological findings, cause of death and proposed role of PMCT during the pandemic. Results : A total of 20 publications were included, mostly case reports (9/20). All cases examined included adults. The most frequent PMCT pattern in positive cases was diffuse mixed densities with prevalence of consolidations (pattern 1) (54%). In 97% of the cases where a comparison between PMCT and histological results was performed, a correspondence was found. In 82% of the cases the principal cause of death was COVID-19 pneumonia. PMCT has been proposed as a pre-autopsy screening tool in 62%, and as a method for augmenting post-mortem data in 50% of the papers reporting this issue. Conclusion : This systematic review suggests that PMCT should be regarded as a highly valuable investigative technique for the forensic evaluation of deaths with ascertained or suspected COVID-19 pneumonia. | N/A | 2022 | | CORD-19 |
| 976 | Musculoskeletal Sequelae following COVID-19 mRNA Vaccination: A Case Report Background COVID-19 is among the most deleterious pandemics the world has ever faced. With millions of people now having received the unprecedented COVID-19 vaccines and many millions yet to receive it, it becomes imperative to determine the side effect profile of these vaccines. Case Report Herein, we present a case in which a patient developed inflammatory fasciitis of the shoulder girdle and sternoclavicular joint inflammation requiring hospital admission following COVID-19 vaccination. The patient is a South Asian male of Indian origin residing in the United States. Conclusion Our report aims to share the scenario in which a patient developed severe pain, muscle spasms, inflammatory fasciitis in the shoulder and inflammation in the SC joint in the post-vaccination setting following the second dose of the Pfizer-BioNTech COVID-19 vaccine. To our knowledge, this is the first such reported case, and therefore this contribution of the presentation and pathogenesis of this orthopaedic complication may provide further information regarding clinically adverse effects from this nascent immunological advancement. | N/A | 2022 | | CORD-19 |
| 977 | Methylprednisolone in the treatment of lymphangioleiomyomatosis This case report proposes the use of pulsed methylprednisolone in a patient with lymphangioleiomyomatosis (LAM) who was invasively ventilated. A 38-year-old, East Indian gravida 4, para 1(+2), patient with worsening respiratory function with spontaneous pneumothoraxes and hypoxemia was pulsed with methylprednisolone leading to rapid resolution of respiratory failure. The author proposes pulsed methylprednisolone in ventilated LAM patients, which gives another option to patients which resulted in alleviation of hypoxemia and maintaining foetal viability. | N/A | 2022 | | CORD-19 |
| 978 | Public perception of social workers as a source for providing help during the COVID-19 pandemic SUMMARY: The current study examined the contribution of select demographic and psychosocial variables, as well as prior experience with social workers (SWs), to explaining the likelihood of seeking their help by the general public in Israel during the COVID-19 pandemic. For the purpose of the study, an online questionnaire was administered to a sample of 582 respondents older than 20. FINDINGS: The findings show that the respondents reported a fairly low likelihood of seeking help from SWs. Women, those not in a significant relationship, people who had prior experience with SWs, and those reporting higher levels of loneliness, had a higher likelihood of seeking help from SWs. At the same time, no association was found between age, employment status, depression, and anxiety, and the likelihood of seeking help from SWs. APPLICATIONS: When dealing with the mental, health, and social consequences of the COVID-19 crisis, it is important to identify groups with a lower likelihood of seeking help from SWs and to actively offer them help. Furthermore, it is important to develop a policy aimed at promoting knowledge of SW roles and reducing barriers to seeking SW help, while attending to the unique needs of diverse population groups. | J Soc Work (Lond) | 2022 | | CORD-19 |
| 979 | Management of patients with Intestinal Bowel Disease and COVID-19: A review of current evidence and future perspectives The COVID-19 pandemic has been a challenge for countries and health professionals worldwide. Viral entry by ACE-2 receptor and an excessive activation of the immune system are key to understand both incidence and severity of disease. Inflammatory Bowel Disease (IBD) represents a special condition associated with an inordinate response of the immune system to external agents. IBD treatments have been associated to an increased risk of bacterial and viral infections. This has raised the question of possible higher incidence and severity of COVID-19 infection in IBD patients. Several papers have been published during this year of pandemic to answer that question. Moreover, COVID-19 vaccination offers great promise in controlling infection in patients with IBD. Based on current evidence, patients with IBD do not have a higher incidence of COVID-19 than the general population, and they do not have worse disease evolution. Advanced age and presence of a greater number of comorbidities have been associated with worse outcomes, similar to the general population. Corticosteroids are associated to an increased risk of COVID-19 infection, higher hospitalization rate and higher risk of severe COVID-19. 5-ASA/Sulfasalazine and Thiopurines have a possible increased risk of severe COVID-19, although studies are lacking. On the other hand, Anti-TNF may have a possible protective effect. It is recommended to maintain the treatment. Anti-IL-12/23, anti-integrins and tofacitinib have results comparable to anti-TNF. Based on the efficacy, expert recommendations, and the absence of other evidence, it is recommended that patients with IBD be vaccinated. | N/A | 2022 | | CORD-19 |
| 980 | Anxiety and depressive symptoms among hospital staff during the COVID-19 pandemic: Longitudinal results from the international COPE-CORONA study | J Psychosom Res | 2022 | | CORD-19 |
| 981 | Burnout and work engagement among hospital staff during the COVID-19 pandemic: Longitudinal results from the COPE-CORONA study | J Psychosom Res | 2022 | | CORD-19 |
| 982 | Psychotropic drugs in patients with Covid-19: A retrospective cohort study (PsyCovid-19 study) | J Psychosom Res | 2022 | | CORD-19 |
| 983 | Telematic Follow-up in Mental Health (MH) for SARS-CoV-2 (+) users at home: A dam for the fifth wave? | J Psychosom Res | 2022 | | CORD-19 |
| 984 | What we have learned from two decades of epidemics and pandemics: A systematic review and meta-analysis of the psychological burden of frontline healthcare workers | J Psychosom Res | 2022 | | CORD-19 |
| 985 | Euthymia among Italian university students during the COVID-19 pandemic | J Psychosom Res | 2022 | | CORD-19 |
| 986 | Subjective cognitive complaints and neuropsychological performance at six months post-COVID-19 | J Psychosom Res | 2022 | | CORD-19 |
| 987 | Associations between personality characteristics and perceived quality of life in medical students during the Covid-19 pandemic | J Psychosom Res | 2022 | | CORD-19 |
| 988 | Who is at risk of poor mental health following COVID-19 outpatient management? | J Psychosom Res | 2022 | | CORD-19 |
| 989 | Features of mental and behavioral disorders in patients with COVID-19 | J Psychosom Res | 2022 | | CORD-19 |
| 990 | Attitudes towards COVID-19 compared to influenza vaccination among hospital staff | J Psychosom Res | 2022 | | CORD-19 |
| 991 | Associations between symptoms and of symptoms with activity in long covid: an intensive longitudinal study | J Psychosom Res | 2022 | | CORD-19 |
| 992 | Prevalence of primary mental disorders in the COVID-19 acute phase in-patients | J Psychosom Res | 2022 | | CORD-19 |
| 993 | Health anxiety symptoms in Danish children during the COVID-19 pandemic: An Odense Child Cohort study | J Psychosom Res | 2022 | | CORD-19 |
| 994 | Short break drive holiday destination attractiveness during COVID-19 border closures Research into the topic of destination image has been popular in the tourism literature since the 1970s. However, only a minority of destination image studies have focused on the context of short break drive holidays. Domestic holidays have taken on increased importance for the tourism industry in many parts of the world during travel restrictions caused by COVID-19. Building on theorizing from evolutionary psychology, this paper reports a study with the data collected from two samples in New Zealand and Australia during the COVID-19 pandemic. Conjoint analysis revealed the two most important destination attributes in terms of crowdedness and accommodation type, and latent class analysis revealed four segments. These insights have practical implications for marketers of smaller, less crowded destinations interested in the short break drive market, particularly given uncertainties about international leisure travel during the ongoing COVID-19 pandemic and the possibility of future coronavirus outbreaks. | N/A | 2022 | | CORD-19 |
| 995 | Assessment of the humoral immunity induced by Sputnik V Covid-19 vaccine (GAM-COVID-VAC) in healthcare workers Background Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate the antibody response against SARS-CoV-2 in HCWs with complete Sputnik V vaccine scheme and factors associated with an increased antibody response. Material and methods Prospective study to evaluate the anti-SARS-CoV-2 humoral response in HCWs vaccinated with two doses of the Sputnik V vaccine (April-July 2021). The assessment of anti-Spike IgG antibodies in plasma was performed using the COVIDAR IgG enzyme-linked immunosorbent assay. A logistic regression was performed to identify independent factors associated with a positive IgG serology test and an elevated antibody response. Results A total of 630 HCWs were enrolled. Median age (IQR): 47 years (35-56). Female sex: 462 (73.33%). Previous COVID-19: 158 (25%). The median interval time between vaccine doses was 3 (3-4) weeks. Positive serology was observed in 607 (96.35%) HCWs. In the multivariate analysis, a history of systemic reactogenicity was identified as an independent variable associated with a positive serology; and history of systemic reactogenicity, COVID-19, interval between doses ≥4 weeks and time to serology <14 weeks were associated with an elevated antibody response. Conclusions This study provides data on the humoral response to the Sputnik V vaccine in a real-life setting. These initial data can contribute to the development of future immunization strategies in HCWs. | N/A | 2022 | | CORD-19 |
| 996 | HDL-cholesterol concentration and risk of SARS-CoV-2 infection in people over 75 years of age: A cohort with half a million participants from the Community of Madrid Objective The aim of this study was to analyze the relationship between HDL-cholesterol and the risk of SARS-CoV-2 infection in over 75-year-olds residing in the Community of Madrid. Methods Study of a population-based cohort, composed of all residents in Madrid (Spain) born before January 1, 1945 and alive on December 31, 2019. Demographic, clinical and analytical data were obtained from primary care electronic medical records from January 2015. Confirmed SARS-CoV-2 infection was defined as a positive RT-PCR or antigen test result. Infection data correspond to the period March 1, 2020 through December 31, 2020. Results Of the 593,342 cohort participants, 501,813 had at least one HDL-cholesterol determination in the past 5 years. Their mean age was 83.4 ± 5.6 years and 62.4% were women. A total of 36,996 (7.4%) had a confirmed SARS-CoV2 infection during 2020. The risk of infection [odds ratio (95% confidence interval)] for SARS-CoV2 according to increasing quintiles of HDL-cholesterol was 1, 0,960 (0,915-1,007), 0,891 (0,848-0,935), 0,865 (0,824-0,909) y 0,833 (0.792-0,876), after adjusting for age, sex, cardiovascular risk factors and comorbidities. Conclusions There is an inverse and dose-dependent relationship between HDL-cholesterol concentration and the risk of SARS-CoV2 infection in subjects aged over 75 years of age in the Community of Madrid. | N/A | 2022 | | CORD-19 |
| 997 | Implementation of the Hanyu Shuiping Kaoshi and its Home Edition During the Covid-19 Pandemic: A Survey of European Test Centres The Hanyu Shuiping Kaoshi (HSK) test is a standardized Chinese language proficiency test targeting non-native speakers. Compared with other Chinese proficiency tests, the HSK has the largest test population in the world and has attracted the most academic research. This article examines how the HSK was carried out during the Covid-19 pandemic and the issues facing home-based HSK test, the so-called HSK Home Edition. The results of a primary survey showed that the majority of test centres in Europe opted to implement the traditional paper-based format of the HSK during the Covid-19 pandemic, despite the availability of the HSK Home Edition. Concerns related to technical and security issues were among the major factors that hindered successful implementation of the Home Edition. Of the test centres that utilised the Home Edition, they rated their overall experience as satisfactory. This finding suggests that concerns relating to technical and security issues associated with the adoption of the Home Edition may be less daunting than anticipated. Additional training for test centre staff could improve the implementation of the Home Edition. | N/A | 2022 | | CORD-19 |
| 998 | COVID-19 as a stress test: Assessing the bank regulatory framework The broad economic damage of the COVID-19 pandemic poses the first major test of the bank regulatory reforms put in place after the Global Financial Crisis. Our study assesses the U.S. regulatory framework, with an emphasis on capital and liquidity requirements. Prior to the COVID-19 crisis, banks were well capitalized and held ample liquid assets, which partly reflects enhanced requirements. The overall robust capital and liquidity levels resulted in a resilient banking system, which maintained lending and market making through the early stages of the pandemic. Trading activity was a source of strength for banks, reflecting in part a prudent regulatory approach. That said, leverage requirements are associated with more repo position netting by banks, with potential implications for market making. | N/A | 2022 | | CORD-19 |
| 999 | Impact of COVID-19 on children with blood and cancer disorders | N/A | 2022 | | CORD-19 |
| 1000 | Biomarkers of acute kidney injury in predicting chronic kidney disease and mortality in patients with coronavirus infection | Eur Urol Open Sci | 2022 | | CORD-19 |
